1CID


Conserved Protein Domain Family
CD4-extracel
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pfam09191: CD4-extracel (this model, PSSM-Id:286300 is obsolete and has been replaced by 462712)
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CD4, extracellular
Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens.
Links
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Statistics
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PSSM-Id: 286300
Aligned: 20 rows
Threshold Bit Score: 137.827
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1CID_A         2 SITAYKSEGESAEFSFPLNLGEESL--QGELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQlSETLPLTLQIPQV 79  Norway rat
P06332       212 AITAYKSEGESAEFSFPLNFAEENG--WGELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQlKETLPLTLKIPQV 289 house mouse
XP_012664756 129 SSAIYKKEGEQVEFSFPLTFKEERL--EGELRWQAEKASSSKPWVTFFLENNKVSVKWITQDPKLQmEETLPLRFTLPQA 206 small-eared galago
XP_003273798  29 SSTVYKKEGEQVEFSFPLAFTVEKLtgSGELCWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQmDKKLPLHLTLPQA 108 northern white-...
XP_005338429 206 lNTVYKKVGEQVELSFPLNIGDEDL--RGELKWQAERSSSSKTWFTFSLKNKQFSVQKVIQDPKLQvAENLPLRFTLSHA 283 thirteen-lined ...
XP_003496142 209 STIVYKKEGEPAEFSFPLTFQDENL--QGELMWRAEKASSPGPWVTFSLENKKVAVLKSWGTAKLQmKEELPLHLKIHQV 286 Chinese hamster
XP_005610940 211 SRTVYAKEGTQAEFSFPLTFADENL--SGELQWQAEGASSQQKWISFSSDNRKVSVTGVSSHLKLQvEEMLPLRFKLLQA 288 horse
XP_010589211 170 STTIYKKDGEQVKFSFPLTFKDKDL--TGELKWQAEGASSPKTWITFSLNNKKVSTSYIQK--RLQmSEALPLSFTLPQA 245 African savanna...
XP_004869501 204 PRTAYKKEGEALELSFPLTFDDEAH--LGELSWRADRASSSQVWISFSVENRKVSVQMAALDPQLQmAEKTPLRLILSEA 281 naked mole-rat
XP_003463325 210 PNPFYKKEKESLEMCFPLTFNNEDLpfTGELIWRADKASSSHSWITFSVANQRVSVQNDNQDPKLQmAEKTPLCLTLSSV 289 domestic guinea...

1CID_A        80 SLQFAGSGNLTLTLDR--G-I-LYQEVNLVV 106 Norway rat
P06332       290 SLQFAGSGNLTLTLDK--G-T-LHQEVNLVV 316 house mouse
XP_012664756 207 LPQYAGSGNLTLVITS--R-K-LQQEVKLVV 233 small-eared galago
XP_003273798 109 LPQYAGSGNLTLDLEAktG-K-LRQEVNLVV 137 northern white-cheeked gibbon
XP_005338429 284 LPQYAGSGELTLTLDK--G-K-LQKNVKLVL 310 thirteen-lined ground squirrel
XP_003496142 287 SLDNAGSGNLTLTLAK--G-K-LRQEVNLVV 313 Chinese hamster
XP_005610940 289 LPKHAGSGKLRLFLAK--G-E-LQQEVNLVV 315 horse
XP_010589211 246 LPQYAGFGNLTLDLAE--G-K-LHQKVSLVV 272 African savanna elephant
XP_004869501 282 LLQHAGSGNLTLTLAG--DlK-LHQEVNLVV 309 naked mole-rat
XP_003463325 290 LLQHAGSGNLTLTLDG--G-QrLSQEVKLVV 317 domestic guinea pig
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