pfam09041: Aurora-A_bind (this model, PSSM-Id:286173 is obsolete and has been replaced by 430383)
Aurora-A binding
The Aurora-A binding domain binds to two distinct sites on the Aurora kinase: the upstream residues bind at the N-terminal lobe, whilst the downstream residues bind in an alpha-helical conformation between the N- and C-terminal lobes. The two Aurora-A binding motifs are connected by a flexible linker that is variable in length and sequence across species. Binding of the domain results strong activation of Aurora-A and protection from deactivating dephosphorylation by phosphatase PP1.
Jiyao W et al.(2023). "The conserved domain database in 2023.",