Conserved Protein Domain Family
LMF1
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pfam06762: LMF1 (this model, PSSM-Id:284234 is obsolete and has been replaced by 462004)
Lipase maturation factor
This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. The precise role of LMF1 in lipase folding has yet to be determined.
Links
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Statistics
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PSSM-Id: 284234
Aligned: 95 rows
Threshold Bit Score: 193.215
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4N0L2       112 DLLLLEVGFLAIFIfSP--------------FKFFdkh--lslDLPSLVKWSFRLLSYRVVLLSGLYKIFL-------KL 168 Theileria parva
Q16NM9        97 DELLLEAGFLCILL-AP--------------SKLSdp----rsPIEDLALLLMKWLLFRFVFASGSVKLASgcp-lwwDL 156 yellow fever mo...
EFA12890      94 DEFLLEAGFLVLLV-AP--------------LLPGrrkgskvlPSDSISFWLVRWLLFRFLLTCGLLKFISgcp-kwwTL 157 red flour beetle
XP_004991406 139 DILLLEVGFLAAAT-AP--------------LVCVrnq---yhPGGDLMLSLVRWLFFRLMFLSGIVKLTSqcp-twwGL 199 Salpingoeca ros...
XP_001950772 128 DELLLEVGLLCILI-APipfqklrvpskkrnLRLQtsl--aslPHDSIPFWLVRWLLFRVAFSAGVAKMSSkss-iwyDL 203 pea aphid
XP_001861615  90 DEMLLEAGFLCILL-AP--------------AKLSdp----rgPIEGLAMLLMKWLLFRYVFASGSVKLASgcp-mwwDL 149 southern house ...
XP_320610     96 DHLLLEAGFLCILL-AP--------------TRLTdr----rhPMEAIALLLLKWLVFRFMFASGSVKLASgcp-lwwSL 155 Anopheles gambi...
CDJ04968     122 tSLLIEAGFLCFLL-SI--------------KLRKys-----rsASMIVAWLIKWLLFREAVSTGFARLANdny-fwwDL 180 Echinococcus mu...
ETN68032     142 DHLLLEAGFLCILL-AP--------------TRLTdg----rnPMEDIALLLLKWLVFRFMFASGSVKLASgcp-lwwSL 201 Anopheles darlingi
XP_001608870 159 DLLLLEVGFLAALLySP--------------FAFFgyeh-kewGVPSTSRWSYYFLLYRGMFCAGVDRIRQgedpteaGS 223 Babesia bovis T2Bo

Q4N0L2       169 N-FQHILTSIPLPTFFAHFLTRAVAKYSFLNTLLTvglLFYEVVLSVFIVTPHRSCRLFGGMALMVYGSVFTLLGNFGPF 247 Theileria parva
Q16NM9       157 TaLKRHFETMPLPTSYSWYTYQQPDALHRLSTIWV---YLSELVCSWLFFAPNQKVRMFALWWQVFLHLNIIGSGNYGFL 233 yellow fever mo...
EFA12890     158 SaFNYYFETLPLPTPLSWYFHQIPSWYLKLFGVIA---NVCEIGIPFLFFVPIRAVRITSFMIQIFLQISIVLTGNYNFT 234 red flour beetle
XP_004991406 200 TaMDVHYESQCIPTPLAWFAHQLPHWFQAFSVVQV---YVIEAVLPFGFFLPFSSVRVVCAVAQVVLMALIFVTGNYNFF 276 Salpingoeca ros...
XP_001950772 204 TaLSKYFESMPLPNAISWYAHYFPLWFLKTITVFA---EINDLFVPLMFLVPIRSVKKLAFYIQVFMQVGILASGNYSYY 280 pea aphid
XP_001861615 150 TgLKKHFETMPLPTSYSWYTFQQPDGIHKLSTIYV---YVSELVCSWLFFAPNQRVRMFSLWWQVFLHLNIIGSGNYGFL 226 southern house ...
XP_320610    156 DgLKRHYETMPLPTSYSWYTYQLPDVFHRLSTIYV---YLSELVVPWLFFAPSRTVRRFAVWWHVFLHLNIIGCGNYGFL 232 Anopheles gambi...
CDJ04968     181 SaMEHYFSTQISPTPAAYYLSLAPSLVLRIISLFF---IVMEIFIPFLFLIPVRELQIFSFFAKVMFHADLIVIGNHGIY 257 Echinococcus mu...
ETN68032     202 DgLRRHYETMPLPTSYSWYTYQLPEAFHRLSTIYV---YLSELVVPWLFFAPNRVVRRFALVWHVFLHANIIGCGNYGFL 278 Anopheles darlingi
XP_001608870 224 DdLKNLMEAIPLSSTITQMVYDFLSGSSVLTTIISstpLFVELVASVSLIIPIRKCRIIGGFVALFYTLFLGCVSENGSY 303 Babesia bovis T2Bo

Q4N0L2       248 YILLLLTSLFCLDdqflhpftqwkfnpfaksdtlmkkvsidliesltnsgdsvesvenvenedpvdtvesvdnvdnvlec 327 Theileria parva
Q16NM9       234 SLIVLTLLLTLVDdrelars------------------------------------------------------------ 253 yellow fever mo...
EFA12890     235 NLLMVTLLLSLLDdqffygrr----------------------------------------------------------- 255 red flour beetle
XP_004991406 277 NILTALLAIPVLYdne---------------------------------------------------------------- 292 Salpingoeca ros...
XP_001950772 281 NLLYIVLCLSLLDdhtfyrelal--------------------------------------------------------- 303 pea aphid
XP_001861615 227 SLIVMTLLLTLVDdrelvqpv----------------------------------------------------------- 247 southern house ...
XP_320610    233 SPLVLTLLVALLDdedelvvtaar-------------------------------------------------------- 256 Anopheles gambi...
CDJ04968     258 NLLSIVLSFALLPepk---------------------------------------------------------------- 273 Echinococcus mu...
ETN68032     279 SPLVLTLMVTLLDdddklllkllrdnpgttnsg-------------------------------------------nsgv 315 Anopheles darlingi
XP_001608870 304 YLLLASTSILCFDdyfweeigcgflnslvkheaehtledl--------------------------------aesrqdde 351 Babesia bovis T2Bo

Q4N0L2       328 ntvrseecteetfgsvYi-ERI--------LSNLSYnrhrE-------------------------YL-RDFMNLDNLSV 372 Theileria parva
Q16NM9       254 ----------pvkkapRk-EDK--------TGALTVkvifI-------------------------LMvLGTWLAFGVGY 289 yellow fever mo...
EFA12890     256 --------kpftkwtfI--EKV--------INILTY----G-------------------------ALlLAVVKLYSLKL 288 red flour beetle
XP_004991406 293 -------------lkaVvsSRF--------VDMHVS----ArkqglrlikrlpwwaealflliaalAVgTFTAHAFDVHV 347 Salpingoeca ros...
XP_001950772 304 ------artrqwcstvF--TRL--------MTINVI----T-------------------------VLiAVFPMLYNFRI 338 pea aphid
XP_001861615 248 --------keeskedkT--GAM--------TVKAIA----V-------------------------LMtLGTWLVFGVGY 280 southern house ...
XP_320610    257 -----qtnstddsadrY--GGR--------LVKAIS----L-------------------------LMvVGSWLCFSVGV 292 Anopheles gambi...
CDJ04968     274 -------------rykG--SSVshrfvsvaTTVAVL----T-------------------------VLfYGVWVFFGFQE 309 Echinococcus mu...
ETN68032     316 errtrggvvrnqaepnNd-SDR--------IGNRIVkvigV-------------------------LMvVGSWIIFGIGF 361 Anopheles darlingi
XP_001608870 352 sapipdsnsipmttpqslkETI--------INLLTYkrekQ-------------------------WLgKTLFSRDSFGI 398 Babesia bovis T2Bo

Q4N0L2       373 SE------------L-----------------FKK---------------IITDLLfllyltvilvll--------llll 400 Theileria parva
Q16NM9       290 KN------------G-----------------Elafkllf---nrsqylnMMQMML------------------------ 313 yellow fever mo...
EFA12890     289 DGtiiesniaftkdQ-----------------FEY---------------VLKQGL------------------------ 312 red flour beetle
XP_004991406 348 QA------------D-----------------MHVpitatvaftkqqfshWLTRAL------------------------ 374 Salpingoeca ros...
XP_001950772 339 SP------------A-----------------NTPdftiaft--hqqfnvILGKSL------------------------ 363 pea aphid
XP_001861615 281 KN------------G-----------------ENG----------------VQAVV------------------------ 291 southern house ...
XP_320610    293 SK------------D-----------------DGQltfqptf-tqdqylnVMQTMI------------------------ 318 Anopheles gambi...
CDJ04968     310 GI------------EamritilrkefidqaktVNY---------------YTILIV------------------------ 338 Echinococcus mu...
ETN68032     362 SS------------S-----------------EDGyltfktnfskdqylsVMPVML------------------------ 388 Anopheles darlingi
XP_001608870 399 E--------------------------------------------------MTEGNyhkwqraiqvilicgismfvldim 428 Babesia bovis T2Bo

Q4N0L2       401 lfphykgVK--------SLILFLVCVL-----------------------------LKS--------------------H 423 Theileria parva
Q16NM9       314 -------RA--------APLLVLSLMV-----------------------------QKF--------------------L 329 yellow fever mo...
EFA12890     313 -------TI--------TIYLGLISLA-----------------------------VTI--------------------L 328 red flour beetle
XP_004991406 375 -------EA--------GIVLGAIGVA-----------------------------VPC--------------------M 390 Salpingoeca ros...
XP_001950772 364 -------PF--------IAYFALGSFV-----------------------------FEClkalysslplksktdgslsaL 399 pea aphid
XP_001861615 292 -------PPdrrypehdADDGSACSAAgdgtdgaevpsrsvpkqtgttnvadgirkLTE--------------------N 344 southern house ...
XP_320610    319 -------RA--------APLLVFVLLV-----------------------------KQF--------------------L 334 Anopheles gambi...
CDJ04968     339 -------SS--------FFVLNLLAAM-----------------------------FRS--------------------L 354 Echinococcus mu...
ETN68032     389 -------LA--------APLLVFGLLV-----------------------------RKF--------------------L 404 Anopheles darlingi
XP_001608870 429 vernshgTN--------AIVVFFLSLL-----------------------------LQV--------------------Q 451 Babesia bovis T2Bo

Q4N0L2       424 ceavrtkisllqgeytlfllqsilifemvkngpntwsfllwigltelqlnlskkmdnmhhltkmiiqsflfiHLI----- 498 Theileria parva
Q16NM9       330 kivnkqagvttva----------------------------------------------dgirklsenwqlfLPM----- 358 yellow fever mo...
EFA12890     329 ralsislfdvq--------------------------------------------------gskvftiittiLYS----- 353 red flour beetle
XP_004991406 391 va--------------------------------------------------------------------vfKALrkcnl 402 Salpingoeca ros...
XP_001950772 400 it--------------------------------------------------------------------stLYV----- 406 pea aphid
XP_001861615 345 wq--------------------------------------------------------------------lfLPT----- 351 southern house ...
XP_320610    335 kllssqdsvgsla----------------------------------------------egmrqfsknlgllIST----- 363 Anopheles gambi...
CDJ04968     355 strgcmnr--------------------------------------------------------mldftgvaLVG----- 373 Echinococcus mu...
ETN68032     405 kllsfqdtvgsla----------------------------------------------egarqftknlgllIST----- 433 Anopheles darlingi
XP_001608870 452 cnvlgtrssylkvagtlfaihmwlviemmiggvhwwnallwigtaelqlglcnsktnfytvanlmiqsvlglIIL----- 526 Babesia bovis T2Bo

Q4N0L2       499 ----------VFSVRVfqhsVTEILTPQ--------SnnirsvnintmsnintmsniN-------------TMSNintIS 547 Theileria parva
Q16NM9       359 ----------LAAFAV----LFTSIVPH--------Fqltes----------taistS-------------ILTK---PY 390 yellow fever mo...
EFA12890     354 ----------GIAVLL----FFASTVPLaslhtasnStv-----------------hP-------------SVRT---VY 386 red flour beetle
XP_004991406 403 ghlasvlprvGVAALL----FAASIETL--------Rw-------------------NdrafrlhtapgyeVVQQ---SH 448 Salpingoeca ros...
XP_001950772 407 ----------SICLGI----FSLSSVNF--------Salhqsv---------nntvpK-------------DLKL---FY 439 pea aphid
XP_001861615 352 ----------LAAFIV----LFTSIVPH--------Fqltqs----------taissS-------------IFTK---PY 383 southern house ...
XP_320610    364 ----------IVAFTV----FFMSIVPH--------Srllps----------tavtsP-------------VMTR---AY 395 Anopheles gambi...
CDJ04968     374 ----------LMGGGL----FAASLAPF--------Sslvdss--------svvplpS-------------FAYE---LT 407 Echinococcus mu...
ETN68032     434 ----------IVAFTV----FFMSIVPH--------Srllps----------taissP-------------VMTR---AY 465 Anopheles darlingi
XP_001608870 527 ----------YYAVPV----VILSLKSK--------An----------------------------------------kA 544 Babesia bovis T2Bo

Q4N0L2       548 SGMNNFYSVSNYRNVFR--------VG--R--DR---Y---ELVIEGTNESVvttrTHWEEYYFKRKPSKLDQFPH--LT 607 Theileria parva
Q16NM9       391 QGLHNLFVVNQYG--QH--------LN--K--MRpkrL---EIILEYADDLT----GPWHEYGFQYKPW--NQEGSmpYA 447 yellow fever mo...
EFA12890     387 NRLHKLHAVNQYGLFPK--------MM--GvdGR---P---EVILEGSDNVE----GPWLEYNFLYKPGNVNHSLPf-VA 445 red flour beetle
XP_004991406 449 QLLDPLQVVTSYGLFRG--------MSgvG--GR---P---EVSVEGSRDAR----T-WHDYAFKSKPGKVTGRPPf-IA 506 Salpingoeca ros...
XP_001950772 440 NKLAPYKISNSYLPPKE--------FInlE--NR---K---EIVIQGASDIK----GPWYEYQFLYKPGNVNVTPPi-IA 498 pea aphid
XP_001861615 384 NGLHNMFVVNQYG--QH--------LI--K--MR---PkrvEIILEYSDDLS----GPWKEYGFQYKPWNEAGSMP--YA 440 southern house ...
XP_320610    396 GGLHSLYVVNQYG--RH--------LT--K--MR---PmrrEIILEYGDELN----GTWHEYGFQYKPWTVERAASl--- 451 Anopheles gambi...
CDJ04968     408 AALKPFHLANDYRFFHQkekdvllkVD--R--QR---T---VLVLEGAMNEN----GPWKELSFHHVPSTPEKMPSv-IP 472 Echinococcus mu...
ETN68032     466 GGLHSLYVVNQYG--RH--------LT--K--MRpvrR---EIILEYADDLN----GTWQEYGFDYKPWTVERTSSlpYA 524 Anopheles darlingi
XP_001608870 545 SIMAPFGIVNRYDSSEV--------IG--E--RA---P---DVIIQGTSDDIvttgTKWKSYGLHTVPTDPDSLTV--NN 604 Babesia bovis T2Bo

Q4N0L2       608 Pf---YQYFLDDILvqsfnlqynnsnsnsnsssnrnnrnsvrkkkyvvttgdtgdtgdtvegtgdsvdrvngdelpyAVT 684 Theileria parva
Q16NM9       448 Wv---YFPRFDFKF---------------------------------------------------------------YDA 461 yellow fever mo...
EFA12890     446 P----YSPRLDWQM---------------------------------------------------------------FWA 458 red flour beetle
XP_004991406 507 P----HQPRLDWQM---------------------------------------------------------------WFA 519 Salpingoeca ros...
XP_001950772 499 P----YKPLLDRQL---------------------------------------------------------------FFA 511 pea aphid
XP_001861615 441 Wv---YFPRFDFKF---------------------------------------------------------------YDA 454 southern house ...
XP_320610    452 PygwlHFPRFDFKF---------------------------------------------------------------YDA 468 Anopheles gambi...
CDJ04968     473 G----HLPVVDFEA---------------------------------------------------------------ALS 485 Echinococcus mu...
ETN68032     525 Gl---YFPRFDFKF---------------------------------------------------------------YDA 538 Anopheles darlingi
XP_001608870 605 Gg---YVYEIDNLLrdvakk---------------------------------------------------qqgeqaTVM 630 Babesia bovis T2Bo

Q4N0L2       685 EK-------FIFDLLRMLLMGSGEVKNLM---Y---N--PFeGT-KPKYTRVLLYKYYFSNlhsg---nsntRsKNWYYR 745 Theileria parva
Q16NM9       462 SNskpynqkWLYPLVQRLLQNEPAVAKLLdedH---V--PSk---PPKYIRASLYHFSYTSwf-------egNsTTFWTR 526 yellow fever mo...
EFA12890     459 AYntydkqpWILSLTHRLLTGKAEVLALLdrhH---S--PF-NQkPPKYIRGILYKYKYSSwsq-----rsqP--SWWVR 525 red flour beetle
XP_004991406 520 ALgsiehnpWLQHLAIRLLEGEPAVLDLLe--KeqpD--DM-HVrPPKYIRMRHWTYHYTNateavgetaplR-GQWWKR 593 Salpingoeca ros...
XP_001950772 512 AHslpaqnpWLMSVLYRLLNNQKEVLSLLn--T---NqiPF-GKnPPKFVKVSLYKYQFSSklq------reR-GVWWNR 578 pea aphid
XP_001861615 455 SAtkptsqkWLYPMVQRLLQNNQAVTKLFd--Q---S--HI-PPgPPKFIRASLYEFRFTSwfh------gnS-TTFWTR 519 southern house ...
XP_320610    469 AGsksdaqkWIYPLVQRLLDHQQPVLDLLd--S---R--HV-PAeAPRYVRTSLYRFAYTSfad-------aaaGGFWTR 533 Anopheles gambi...
CDJ04968     486 GErtfenspIVATLVYRILTKEKEVLALLe--P---S--GF-PI-GPKFVQIRKYTYEISRsi---------ngPQWWKR 547 Echinococcus mu...
ETN68032     539 AAskldaqkWFYPMVLRLLQHQLPVLDLFdghH---V--PFk---APRFIRASLYQFSYTTspt-----kdtVdGAFWER 605 Anopheles darlingi
XP_001608870 631 PR-------FLLSLLRALLLNKPAALGLFa--T---N--PFrES-PPKYVRVIQYNYTIsg----------aRgKPWHIR 685 Babesia bovis T2Bo

Q4N0L2       746 N-LVT-ELIPPL 755 Theileria parva
Q16NM9       527 E-RVN-DYFPAY 536 yellow fever mosquito
EFA12890     526 Q-KVG-EYFPAY 535 red flour beetle
XP_004991406 594 EmRPG-LYMiev 604 Salpingoeca rosetta
XP_001950772 579 Q-ILNsEFIAPM 589 pea aphid
XP_001861615 520 E-RLN-DYFPAY 529 southern house mosquito
XP_320610    534 E-RLT-DYFNVF 543 Anopheles gambiae str. PEST
CDJ04968     548 K-LQN-IYLPPT 557 Echinococcus multilocularis
ETN68032     606 N-RLG-DYFSVF 615 Anopheles darlingi
XP_001608870 686 R-KRT-QIVPPL 695 Babesia bovis T2Bo
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