O43264         9 L----------------------AHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYS--EFLPSMQSAQGLITQVD 64  human
O48626         1 MpeidalfesinvrdllaghdlnDPTTPLSAPDLRLLINRLESHSLRIKSKVQSYLVAHHS--DFSELFSLCQDTVSRTR 78  thale cress
O44218        10 Lpe------------------mfQSNGCASLEDTKSTVSKVQTRTERFQERVRKHIDENYS--EFMTNHTSPDIFLEESS 69  Drosophila pseu...
NP_956435      9 L----------------------ASSGKLEKDDLACKISKLSRKVEETKEEVTDMINKKYI--EFIPSMEGAEELLDQVE 64  zebrafish
NP_001116261   9 L----------------------ANSGRLEKEDLGTKISRLSRRVEELKGEVCDMINKKYD--EFLPSMQCAEDLVTQVH 64  western clawed ...
CAF97316       9 L----------------------ASSGKLEKEDLSGKISKMSRKVEETKEELYEMINKRYA--DFLPSLQSSEQLMIQVD 64  spotted green p...
XP_001625466  20 L----------------------QKTGQLEQEDFNKCATKMLKKAEEVKAEVFNTIYKEYSyaGFQDLSSSTSELNWKVS 77  starlet sea ane...
XP_002634365   1 M------------------------------PSSEGSYRDLEKKLKDGLTSISADIVDKYGnlKVALNINNTAKLIFDRL 50  Caenorhabditis ...

O43264        65 KLSEDI-DLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQL-QEFSTAI-----EEYNCALTEKKYVTGAQR 137 human
O48626        79 LISDDVsDVLQLVSDRPIDVEIRSVVDEITEKTKEVKLKRESLDLVNAI-VGICEAL-----QETKEALKNGRFRFAAER 152 thale cress
O44218        70 SLGREInDLLET-VGTEGLAALNGSSTQLADHSRELRELMLGLQVSEHI-LKIDELF-----QCVEEAKGTKDYLVVLDL 142 Drosophila pseu...
NP_956435     65 SVSKDI-DLLKSCIENEVQQNLHDAVTEYAKLKQQLEKNTAVIDLLQHL-QEFDTAI-----EEYHRALQEKNYVVAAKQ 137 zebrafish
NP_001116261  65 GLASDV-DVLKSRIETEVKSDLKVAVNEFTELKQQLEKNTVILGVLEQL-QEFDSAI-----EKYNCALASKNYISAARH 137 western clawed ...
CAF97316      65 EVSKEM-EALKNCIKNEVWLDLNP-----TTKDRQADRSANSLFYLTSLcLQFHNAM-----EEFDKALPNKDYVEAANM 133 spotted green p...
XP_001625466  78 SLLKEI-DATTKKVKGSILPDLDAAAEEHANLVQQLKETDMVRVILIRL-GKIHLGL-----ETLPGTLKSKAFCKAAKL 150 starlet sea ane...
XP_002634365  51 ENLEDTaEMSSRELSNLIEQTEKDSPEMLAEIKTQARSCENLVEFLQSM-KKVEEQLiimrsKTTNRIEWGNAILACKDY 129 Caenorhabditis ...

O43264       138 LEEAQKCLKLLKSRKCFd-----------LKILKSLSMELTIQKQNILYHLGEEWQKLIVWKFPPSkdt-sslEsyLQTE 205 human
O48626       153 IRELKVVLRIGEEEDGE------------PVAYALLRKEWSNCFDEIQEVLAKFMENAVRFELDSS-------R--IRIK 211 thale cress
O44218       143 VGRLRSLIYG----EGEaatqdvvrifqaLECYETIKVKYHVQAHLLQQNMQERFDRLVQLNCKSF-------PnsKCVT 211 Drosophila pseu...
NP_956435    138 HGTARACVDALKTWKDTe-----------LPIVRALSSEITIQRENLIYHLGEEWQKLAVWKLPSTkteltgaKsfLKTA 206 zebrafish
NP_001116261 138 LEKAHSCLKVLKSRKGCe-----------LKLLKSLGIELTVQKQNLLYHLGEEWQQLAVWKLPPSken-ssvEmiLKTE 205 western clawed ...
CAF97316     134 LERARTSVDSLKVWKLSq-----------VPLLGALSSELTVQRENLIYHLGEEWKRLIIWKLPPSndp-agpQsfLSVA 201 spotted green p...
XP_001625466 151 LEDVKEDLEHV-PRAGQe-----------GKIFIALREELRRLSIQLVNKLDTTWNNCLLWSIPTSssl-dsaHahLKTQ 217 starlet sea ane...
XP_002634365 130 LNETNLLLEGIQCEGFDm-----------SIPLKHFAAEYSVLSYNCRYQLSADYDRAMSVPKVSKkqg-gdkSnvSVTV 197 Caenorhabditis ...

O43264       206 LHLYTEQSH-----KEektpmpPISSVLLAFSVLGELHSKLKSFGQMLLKYILRPLASCPSLHAVIESQPN-I-----VI 274 human
O48626       212 YQLSVGETA-----GI------ALSTVLEAMEVIGILDYGLAKAADSIFKHVITPAVTHASTFAAVEDLCKsAgevteAT 280 thale cress
O44218       212 LLVSKEEGQ--------------LHDIVIALF---QERYNPVRLCEFLLENCIEPLILKPVGVECNENAEAgTyv--qLS 272 Drosophila pseu...
NP_956435    207 LHLNKGGSK-----VDesvphaLLSSILQALSIQGELHKKIKLFGQVLFKYILKPLILYPSLVVEVSSQPEqG-----AV 276 zebrafish
NP_001116261 206 LHLCTLPSNdesttGP------LLGSVLQAFAILGELNTKLKFFSQLLLNYILKPLVTYPSLHAQMETQQQg------VI 273 western clawed ...
CAF97316     202 LNLSHACVE-----GPeakpsaLLCCVLQALAIQGELQNKIKLFSQALVKSMLKPLVVHPSLWVNVVEQQDeG-----IV 271 spotted green p...
XP_001625466 218 LKLCTYGSE--------------ITEVINALAFLGRLEQKLKIFGKKLIQFIFRPLIIFPNLKVSVEKDKEd------IT 277 starlet sea ane...
XP_002634365 198 LNLSTPEEQ-----KN-------MNETLTAMNMIGQLPERLDAWKTVIL-NVFCEAIVSSRDGVDVFFVDNpTpaqtrFL 264 Caenorhabditis ...

O43264       275 IRFESI-------MTNLEYPSPSEVFTKIRLVLEVLQKQLLDLPLDTDlenekt-stvplaEMLGDMIWEDLSECLIKNC 346 human
O48626       281 LRLEQSs------DHKFEDVDGDAMYSGILKVVKFICSSLCFGNVTWI-------------HSFGRLTWPRISELIISKF 341 thale cress
O44218       273 LSYSTKesgtasgTSTQLRPNYKQVLEHFRLLLQTLSGINHSLSSSQHv-----------fSIIGDHVKDRMMHLLVNDC 341 Drosophila pseu...
NP_956435    277 LSLQCL-------ETKAEHPDPSQVYTKVLTVLKTLHEHLFDVSVDEKkv----------sEILGGLIWEEMSECIIREC 339 zebrafish
NP_001116261 274 LRFESV-------ETQSEHPPPSEVFIKLRLVFELLHKHLLDVPVEDSpqvsgetgkvvlaEVLGEMIWEEISEAIIKDC 346 western clawed ...
CAF97316     272 LAFESLq------ESSKERSTPSQVYSKLLMVLKTLHAHLLDVSIGDKrl----------sTILGELIWEEMSGCIIHEC 335 spotted green p...
XP_001625466 278 ISLVRD-------TTKCKIVEPGKVYSKIIEVLEVLCTY--FTPSQDNsglpk----isilQYLGNFLWPALSEDLIKDC 344 starlet sea ane...
XP_002634365 265 INQKPR-------GKKDKPMDVEKVLQSMDVFFSKLSDVLKSHELLDAcgk-------sfvAMIGHAIQPQLNEMILKDV 330 Caenorhabditis ...

O43264       347 LVYSIP--TNSSKLQQ-YEEIIQSTEEFENALKEMRFLK-GDT-TDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHN 421 human
O48626       342 LSKVVP--EDASKLAD-FQKIIERTSQFEAALKELNFVSsSDAeSRLSKYAEDVEVHFASRKKIEILAKARNLLLQCNFT 418 thale cress
O44218       342 LIPAVP--ETMEEYQA--STLCEDVAHFEQYLADSFLIN-PEVdRGLSQFIEQYGTYYRNRLCSRVLESTREIIQRDLQD 416 Drosophila pseu...
NP_956435    340 LVHSIP--ANSSQLAE-YSEVIKQTEDFESSLKEMGYLA-GDS-TELLKYARNVNCHFASKKCQDVIVAARKLMTSEMHN 414 zebrafish
NP_001116261 347 LVYSIP--NNSSKLVQ-YDEVINATEEFENALKGMNYLK-GDA-TDLLKYARNVNAHFASKKCQDVIVIARNLMTSEIHN 421 western clawed ...
CAF97316     336 LVHSIP--NNSSELEK-YTTVIKQTEEFEKALKDMDFLQ-RDS-TDLLKYARDINCHFASKKCKDVIVAARKLMTSKMHN 410 spotted green p...
XP_001625466 345 LAKSIP--NTSAQLEK-YQEVISQTEKFEEELHQLEIVD-KLP-SSLTKYAKDVGVHFGNKKCQDLLVTARDLMKDDIYN 419 starlet sea ane...
XP_002634365 331 VAIAAPvtETAEEDQEmFLRLLQFGEDFVENMKTLGFFS-PDA-KLL--FSLDTDTIFVTRRCFAIVSKANKLINETYDK 406 Caenorhabditis ...

O43264       422 TVkiipdskinvpelptpd---------------------------------------------------ednklevqkv 450 human
O48626       419 IP------------------------------------------------------------------------------ 420 thale cress
O44218       417 MVlva--------------------------------------------------------------------------- 421 Drosophila pseu...
NP_956435    415 TVkitpeyklsipkllsps---------------------------------------------------ggekerkess 443 zebrafish
NP_001116261 422 TVkitpdskitvptlsky-----------------------------------------------------egsekiikk 448 western clawed ...
CAF97316     411 TVkitpdyklrlpklp--------------------------------------------------------apgpevkv 434 spotted green p...
XP_001625466 420 TVmvdrftdtallvtpqeiqeallgkkskvknpvntvlkainhnyllvynahffhaeliltwqplairlpssymeyywic 499 starlet sea ane...
XP_002634365 407 LVtvgvddtavkdidllsk---------------------------------------------------ahthaelyak 435 Caenorhabditis ...

O43264       451 sntqyhEVMNLEPENTLDQHSFSLPTCRISESVKKLMELAYQTLLEA-TTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKE 529 human
O48626       421 ------QDIAMRNAKHIVCLLFSSERCVVSEAASQLMNLVHKTLEDV-CVSSARVASEFYNAARDSILLYEAVVPVKLEK 493 thale cress
O44218       422 --------pnNQAMDVTGCDPFLFPRCMVSRSAQDFMKLMERILRQPtEKPGEDEADPLAGVIGMMLQTYIDEVPKVHKK 493 Drosophila pseu...
NP_956435    444 krsghyDQQSLENEKQLSPNTLCLPVCRISESVQQLMDLAIQTLSEA-VGSSPQCGVQLFYTVRNIFHLFYDVVPTYHKD 522 zebrafish
NP_001116261 449 enhlsqEAPGLENDVKLSQHTFALPTCRISESVQKLMELAYQTLSEA-TTSSKPCSIQLFYTVRNIFHLFYDVVPTYHKE 527 western clawed ...
CAF97316     435 kpeatrEELTMENAKQLSALSLCLPACRISESVQQLMELALHTLCEA-VGSSAYCALHLFITVRNVFQLFYDVVPTYHKE 513 spotted green p...
XP_001625466 500 hqqeisELTKSDQEETLSEFTFNFPTCRISESTKKLMDLAYSTLIEA-TTSPFQTAVQLFYTVRNVFELYCSVVPAYHQD 578 starlet sea ane...
XP_002634365 436 eygndlARLWSHNEESQFPSFFAFQKCTVSASTISFVNLLRDNVKAAfACEDEGARAKLALTAENIVRLYVIQSPRKHAE 515 Caenorhabditis ...

O43264       530 NLQKLPQLAAIHHNNCMYIAHHLLTLGHQFRLRLAPILCDgTATFVDLVPGFRRLGTECFLAQMRAQKGELLERLSSARN 609 human
O48626       494 QLDGLNEAAVLLHNDCLYLFEEILGLAFEYRASFPSSIKE-YAVFADIAPRFKLMAEEVLQKQVHLVISSLREAIDSADG 572 thale cress
O44218       494 LLESIPQQSVLFHNNCMYFTHWVAQNANKG-----------IESFPALVKTLQATGTMHFRVQVTYQTSILMDIMES--- 559 Drosophila pseu...
NP_956435    523 NFLKLPHLAAIQHNNCMFIAHHLLTLGFQFKPYLP--LKDgVAYFVDLVPGFRRLGALCFVAQMNVQKAEMLERLSTARN 600 zebrafish
NP_001116261 528 NLQKLPQLSAIHHNNCMYIAHHLLTLGHQFRYHLPSPLSDgAATFVDMVPGFRRLGTESFLAQMRSQKADLLERLSNARN 607 western clawed ...
CAF97316     514 NLLKFPHLAAIQHNNCMYLAHHLLTLGHHFKAHLPQPYGRgLATFVDMVPGFRRLGARCFLAQMNVQRSELLERLSTAHN 593 spotted green p...
XP_001625466 579 NLATLPQLSALHHNNCMYISHLLMTAGHQFSAQLPEPLGVgTVTFMDLVPTVREIGEKCLFEQLKRQRSQLLSTIRAAEG 658 starlet sea ane...
XP_002634365 516 LFSSIPNMSAIFYNNCHYISHCIMTMSFEASGENQKTLLE--PLLVDSVIRLRNVAADCMEKTLTRCRREMSAYLEDHSI 593 Caenorhabditis ...

O43264       610 FSNMDDEENYSA 621 human
O48626       573 FQNTHQIKQFKS 584 thale cress
O44218       560 FEFESPHTLGTG 571 Drosophila pseudoobscura pseudoobscura
NP_956435    601 FSNLDDEENYSv 612 zebrafish
NP_001116261 608 FSNMEDEDNYTA 619 western clawed frog
CAF97316     594 FCNLDDEDNYVA 605 spotted green pufferfish
XP_001625466 659 FADANEDHRSSQ 670 starlet sea anemone
XP_002634365 594 FEHLPASYKTTK 605 Caenorhabditis briggsae