Conserved Protein Domain Family
NCD2
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pfam04905: NCD2 (this model, PSSM-Id:282725 is obsolete and has been replaced by 461474)
NAB conserved region 2 (NCD2)
Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This family consists of NAB conserved region 2, near the C-terminus of the protein. It is necessary for transcriptional repression by the Nab proteins. It is also required for transcription activation by Nab proteins at Nab-activated promoters.
Links
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Statistics
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PSSM-Id: 282725
Aligned: 16 rows
Threshold Bit Score: 205.691
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q22002       293 YGN----DFVslgdFDPNNPSLTENPTLSTAQISRLAECALAASKNLPP-LPP----RLVQNKKRVSKEVIELLKCSPAT 363 Caenorhabditis ...
XP_003436252 355 lsssnlsstisnqigSTTSGSVQLTPSLTEDQVAKIVQAAERLSRTLPR-LEP----RQQSIKKRSARDLEAVIAMSESD 429 Anopheles gambi...
XP_002026934 277 AHQ----VS---------SSSPQLTPVLTEMQIQRITMCAEKIGRQLPQ-REP----RAQTTRKRTTRELEQVIAMSEHD 338 Drosophila pers...
XP_012545533 232 ASA----GSS----PGSVTSPVQITPVLLDVHVQKLSAAAKKLSKHLPQ-LEP----KPQNTKKKMCKDLELVMLMPESD 298 domestic silkworm
XP_002012178 327 AHQ----VS---------SSSPQLTPVLTELQVQRITMCADKIARQLPQ-REP----RAQTSKKRTTRELEQVIAMAEHD 388 Drosophila moja...
XP_001845945 204 IGS-------------TTTNSLQLTPSLTEEQIAKITAKSFQLAQTIPQqLEP----RQQNVKKRTTRDLEQVMAMNESD 266 southern house ...
KKA78931     278 LHDdfvaLGD----FDPNADT-GETPVLSDAQIGRLNACSQAAVAKLAP-RPP----KLVQNKKKISQDIVDLMAMQPMH 347 Pristionchus pa...
XP_003476212 218 EGT----GAG----GMAASGTGGGPDRLEPEMVRMVVESVERIFRSFPR-GDAgevtSLLKLNKKLARSVGHIFEMDDND 288 domestic guinea...
XP_011665954 176 SPS----PAV----FNSAPISRTDNPALSREIVENIRASAENVVHS----EGL----SSLPLNKKITREVEYILGMSPDH 239 purple sea urchin
ETE62129     161 EEE-----GG----VTSPSEPPSSTEHLDPELANAVSEGVDRLLRSCPR-SGDvelkTLLKLNKKLAKTVGHIFQLDNGD 230 king cobra

Q22002       364 PSMIHAFRKYSAIYGRFDTKRKPHKVLTLHETTVNEAAAQLCLLVPS--LLTRRDELFPLARQIVKDAGYNYAKSRKR 439 Caenorhabditis el...
XP_003436252 430 PRRMDEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQICKYIPA--LLTRRDELFPLARQVVRDCGFGHSASIRL 505 Anopheles gambiae...
XP_002026934 339 PRRMDEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQLCRNPQTiwLLTRRDELFPLARQIVKDAGFGHSASIAR 416 Drosophila persim...
XP_012545533 299 PRRMEEIRKYAAIYGRFDCKRKPEKPLTLHEVMVNEAAAQMCRCVPA--LLTRRDELFPLARQLVRRAGLHYSKhglp 374 domestic silkworm
XP_002012178 389 PRRMDEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQLCRNPQTiwLLTRRDELFPLARQIVKDAGFGHSASIAR 466 Drosophila mojave...
XP_001845945 267 PRRMDEIRKYSAIYGRFDCKRRPEKPLTLHEVCVNEAAAQICKYVPA--LLTRRDELFPLARLVVKECGFGHSASIRL 342 southern house mo...
KKA78931     348 PRRHDEYRKYSAIYGRFDAKRKADKALTLHEVSINEAAAQICMLAPA--LLTRRDELFTLSRQVVKDAGYHYTKSTSt 423 Pristionchus paci...
XP_003476212 289 SQKEEEIRKYSIIYGRFDSKRREGKQLSLHELTINEAAAQFCMRDNT--LLLRRVELFSLSRQVARESTYLSSLKGSR 364 domestic guinea pig
XP_011665954 240 PNRMEEIHKWSSIYGRFDSKRKLEKPLTLHEVTVNEAAAQLCNVDPH--LILQREKLFPLARQVVRDSGYQYRHGQSR 315 purple sea urchin
ETE62129     231 PRKEEEIRRHSAIYGRGETRRCEGKQLTLHELTINEAAAQFCLRDNS--LLLRRVELFSLSRQVARESSYLSSLKGSR 306 king cobra
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