AAB24152   38 KVEDqVDDVYDVVDEREYAKR-AQEKYGDDWIEED-GTGYAEDLRDFFEDedeysdgEEDRKDLKKKkGVAPNSKKRPRE 115  fruit fly
P33609     56 EVED-LTSVYEEVDEEQYSKL-VQARQDDDWIVDDdGIGYVEDGREIFDDd-----lEDDALDTCGK-GSDGKAHRKDRK 127  house mouse
P09884     50 EVED-FTGVYEEVDEEQYSKL-VQARQDDDWIVDDdGIGYVEDGREIFDDd-----lEDDALDADEK-GKDGKARNKDKR 121  human
P13382     29 DESD-GDRIYDEIDEKEYRARkRQELLHDDFVVDDdGVGYVDRGVEEDWR-------EVDNSSSDEDtGNLASKDSKRKK 100  Saccharomyces cer...
P30320      5 TFFP-TDWRSEDVEPDK-----GEPYFRINIFGKTmDGKTVCVRAKFTPF----------FLLETPEsWSAARTNLFITE 68   Paramecium bursar...
AAA67131    1 MILD-ADYITED------------GKPIIRIFKKEnGEFKVEYDRNFRPY----------IYALLKDdSQIDEVRKITAE 57   Pyrococcus sp.
AAA72101    1 MILD-TDYITKD------------GKPIIRIFKKEnGEFKIELDPHFQPY----------IYALLKDdSAIEEIKAIKGE 57   Thermococcus lito...

AAB24152  116 NEKP-----VTGKASIKNLFSNAVPKKKMDVKTSVKDDDdILADILGEIKeep-aatSEKAEkvIAPAKISVTSRKFDAA 189  fruit fly
P33609    128 DVKKp---sVTKPNNIKAMFIASAGKKTTDKAVDLSKDD-LLGDILQDLN-------TETAQ--ITPPPVLIPKKKRSTG 194  house mouse
P09884    122 NVKKl---aVTKPNNIKSMFIACAGKKTADKAVDLSKDG-LLGDILQDLN-------TETPQ--ITPPPVMILKKKRSIG 188  human
P13382    101 NIKRekdhqITDMLRTQHSKSTLLAHAKKSQKKSIPIDN--FDDILGEFEsgevekpNILLPskLRENLNSSPTSEFKSS 178  Saccharomyces cer...
P30320     69 TAMK-----------YDAIRPSCLP---TKRKNMWGYDGgKMRPMVQFVFk------TLSQMrkAKYRLKNEYQIYESSV 128  Paramecium bursar...
AAA67131   58 RHG-------------KIVRIIDAE---KVRKKFLG-------------------------------RPIEVWRLYFEHP 90   Pyrococcus sp.
AAA72101   58 RHG-------------KTVRVLDAV---KVRKKFLG-------------------------------REVEVWKLIFEHP 90   Thermococcus lito...

AAB24152  190 AAkeyMNSFLNNIKVQEQERKKAEASSDNemlERILKPkaaVPnTKVAFFSSPTIKKEpMPEKTPAKKATEdpFSDNemD 269  fruit fly
P33609    195 AL---LNPFSVHTPKAIPSGKPASPVLRN---EPLLTP---IP-LKRAELAGELAQPE-CPEDEQELGVME--FEDG--D 259  house mouse
P09884    189 AS---PNPFSVHTATAVPSGKIASPVSRK---EPPLTP---VP-LKRAEFAGDDVQVE-STEEEQESGAME--FEDG--D 253  human
P13382    179 IKrvnGNDESSHDAGISKKVKIDPDSSTDkylEIESSP---LKlQSRKLRYANDVQDLlDDVENSPVVATKrqNVLQdtL 255  Saccharomyces cer...
P30320    129 DPiirIFHLRNINPADWMHVSKAFPVETRisnSDIEVEt-------SFQHL-GPSDLKeVPPLIIASWDIEtySKDRkf- 199  Paramecium bursar...
AAA67131   91 QDvpaIRDKIREHSAVIDIFEYDIPFAKRyliDKGLIP------------------MEgDEELKLLAFDIEtlYHe---- 148  Pyrococcus sp.
AAA72101   91 QDvpaMRGKIREHPAVVDIYEYDIPFAKRyliDKGLIP------------------MEgDEELKLLAFDIEtfYHe---- 148  Thermococcus lito...

AAB24152  270 FsclddDENqFDVEKTQQTe-KVSQTKTAAEKTSQSKVAEKSAPKKETTgSPKESESEDISrlLnnWEsICQMDDD---- 344  fruit fly
P33609    260 F-----DES-MDTEKVDEK--PVTAKTWDQETEPVERVEHEADPERGTT-SYLENFLPDVS--C--WD-IDQDDESi--p 323  house mouse
P09884    254 F-----DEP-MEVEEVDLE--PMAAKAWDKESEPAEEVKQEADSGKGTV-SYLGSFLPDVS--C--WD-IDQEGDSsfsv 319  human
P13382    256 LanppsAQSlADEEDDEDSdeDIILKRRTMRSVTTTRRVNIDSRSNPSTsPFVTAPGTPIGikGltPSkSLQSNTDv--- 332  Saccharomyces cer...
P30320    200 ----plAENpADYCIQIATt-----FQKYGEPEPYRRVVVCYKQTASVEgVEIISCAEEADvmNtwMTiLQDEITD---- 266  Paramecium bursar...
AAA67131  149 -----gEEFaKGPIIMIS-----------YADEEEAKVITWKKIDLP----YVEVVSSEREmiKrfLKvIREKDPD---- 204  Pyrococcus sp.
AAA72101  149 -----gDEFgKGEIIMIS-----------YADEEEARVITWKNIDLP----YVDVVSNEREmiKrfVQvVKEKDPD---- 204  Thermococcus lito...

AAB24152  345 FEKSVLTTEQDSTISSD-QQLRFWYW-EAYEDPVKMPGEVFLFGR----TAD-GKSVCLRVQNINRVLYLLPRQFLLDPI 417  fruit fly
P33609    324 QEVQVDSSNLPLVKGADdEQVFQFYWlDAYEDPYNQPGVVFLFGKvwieSVKtHVSCCVMVKNIERTLYFLPREMKFDLN 403  house mouse
P09884    320 QEVQVDSSHLPLVKGADeEQVFHFYWlDAYEDQYNQPGVVFLFGKvwieSAEtHVSCCVMVKNIERTLYFLPREMKIDLN 399  human
P13382    333 ATLAVNVKKEDVVDPET--DTFQMFW----LDYCEVNNTLILFGKvk-lKDDnCVSAMVQINGLCRELFFLPREGKTP-- 403  Saccharomyces cer...
P30320    267 VSIGYNLWQYDLRYIHGrSMMCVDDItGEDNVRLKNLGRLLVGGGev-----iERDLSSNAFGQN-KFFLLDMPGVMQID 340  Paramecium bursar...
AAA67131  205 VIITYNGDSFDLPYLVKr---------------AEKLGIKLPLGRd-------GSEPKMQRLG---DMTAVEIKGRIHFD 259  Pyrococcus sp.
AAA72101  205 VIITYNGDNFDLPYLIKr---------------AEKLGVRLVLGRdk-----eHPEPKIQRMG---DSFAVEIKGRIHFD 261  Thermococcus lito...

AAB24152  418 SKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIg--iEVPQSCDYLEVHYDg---kKPLPNLSADKKY 492  fruit fly
P33609    404 TGKETAIPVTMKDVYEEFDSKISAKYKIMKFKSKIVEKNYAFEIP----DVPEKSEYLEVRYS-----AEVPQLPQNLKG 474  house mouse
P09884    400 TGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKNYAFEIP----DVPEKSEYLEVKYS-----AEMPQLPQDLKG 470  human
P13382    404 -----------TDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELP----DIPSESDYLKVLLPyqtpkSSRDTIPSDLSS 468  Saccharomyces cer...
P30320    341 LLQWFRKNRNLESYSLNNVSKLYLGDQKNDLPAMQIFEKFEGGADdraiIAAYARKDTDLPLKllkkmAILEDITEMANA 420  Paramecium bursar...
AAA67131  260 LYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWETGKGle-rVAKYSMEDAKVTYElgrefFPMEAQLSRLVG 338  Pyrococcus sp.
AAA72101  262 LFPVVRRTINLPTYTLEAVYEAVLGKTKSKLGAEEIAAIWETEESmk-kLAQYSMEDARATYElgkefFPMEAELAKLIG 340  Thermococcus lito...

AAB24152  493 NSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPTP-MSWCNTEVTLTEPKNVELVQDKGkpapPPPLTLLSLNVR 571  fruit fly
P33609    475 ETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKNPQLLNQP-ISWCKFEVMALKPDLVNVIKDVS----PPPLVVMSFSMK 549  house mouse
P09884    471 ETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKSPQLLNQP-VSWCKVEAMALKPDLVNVIKDVS----PPPLVVMAFSMK 545  human
P13382    469 DTFYHVFGGNSNIFESFVIQNRIMGPCWLDIKGADFNSIRnASHCAVEVSVDKPQNITPTTTKT----MPNLRCLSLSIQ 544  Saccharomyces cer...
P30320    421 VKVPVDYINFRGQQVRAFSCLVGKAR-QMNYAIPDDKMWTvD--GKYEGATVLDA--KKGAYFTs------IAALDFA-- 487  Paramecium bursar...
AAA67131  339 QPLWDVSRSSTGNLVEWYLLRKAYERNELAPNKPDEREYErRLRESYAGGYVKEP--EKGLWEG-------LVSLDFR-- 407  Pyrococcus sp.
AAA72101  341 QSVWDVSRSSTGNLVEWYLLRVAYARNELAPNKPDEEEYKrRLRTTYLGGYVKEP--EKGLWEN-------IIYLDFR-- 409  Thermococcus lito...

AAB24152  572 -SMNPKTSRNEICMtISMLTHNRFHIDRPAPQPAFNRHMCALTRP-AVVSWPLDLNfEMAKYKSTTVHKHDSERALSVWF 649  fruit fly
P33609    550 tMQNVQNHQHEIIA-MAALVHHSFALDKAPPEPPFQTHFCVVSKP-KDCIFPCDFK-EVISKKNMKVEIAATERTLIGFF 626  house mouse
P09884    546 tMQNAKNHQNEIIA-MAALVHHSFALDKAAPKPPFQSHFCVVSKP-KDCIFPYAFK-EVIEKKNVKVEVAATERTLLGFF 622  human
P13382    545 tLMNPKENKQEIVS-ITLSAYRNISLDSPIPENIKPDDLCTLVRPpQSTSFPLGLAaLAKQKLPGRVRLFNNEKAMLSCF 623  Saccharomyces cer...
P30320    488 -SLYPSIIRAHNMS--PETLVMDKRFENLPGIEYYEIETGLGTFK---YPQKNDETgEGQGVVPALLDDLAKFRKQAKKH 561  Paramecium bursar...
AAA67131  408 -SLYPSIIITHNVS--PDTLNRE-------GCREYDVAPEVGHKF---CK-------DFPGFIPSLLKRLLDERQEIKRK 467  Pyrococcus sp.
AAA72101  410 -SLYPSIIVTHNVS--PDTLEKE-------GCKNYDVAPIVGYRF---CK-------DFPGFIPSILGDLIAMRQDIKKK 469  Thermococcus lito...

AAB24152  650 LAQYQKI-DADLIVTFDSMDCQLNVITDQIVALKIPQWSRMG-RLRLS--QSFGKR------LLEH--FVGRMVCDVKRS 717  fruit fly
P33609    627 LAKVHKI-DPDILVGHNICSFELEVLLQRINECKVPYWSKIG-RLRRSnmPKLGSRs----gFGERnaTCGRMICDVEIS 700  house mouse
P09884    623 LAKVHKI-DPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIG-RLKRSnmPKLGGRs----gFGERnaTCGRMICDVEIS 696  human
P13382    624 CAMLKVE-DPDVIIGHRLQNVYLDVLAHRMHDLNIPTFSSIGrRLRRTwpEKFGRGnsnmnhFFISdiCSGRLICDIANE 702  Saccharomyces cer...
P30320    562 MAEAKKNdDEFREALYDAQQRSYKIVMN---------------------------------------------------- 589  Paramecium bursar...
AAA67131  468 MKASK---DPIEKKMLDYRQRAIKILAN---------------------------------------------------- 492  Pyrococcus sp.
AAA72101  470 MKSTI---DPIEKKMLDYRQRAIKLLAN---------------------------------------------------- 494  Thermococcus lito...

AAB24152  718 AEECIR--ARSYDLQTLCKQVLKLkgsERMEVNADDLLEMYE-KGESITKLISLTMQDNSYLLRLMCELNIMPLALQITN 794  fruit fly
P33609    701 AKELIH--CKSYHLSELVQQILKT---ERIVIPTENIRNMYS-ESSYLLYLLEHIWKDARFILQIMCELNVLPLALQITN 774  house mouse
P09884    697 AKELIR--CKSYHLSELVQQILKT---ERVVIPMENIQNMYS-ESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITN 770  human
P13382    703 MGQSLTpkCQSWDLSEMYQVTCEK---EHKPLDIDYQNPQYQnDVNSMTMALQENITNCMISAEVSYRIQLLTLTKQLTN 779  Saccharomyces cer...
P30320        --------------------------------------------------------------------------------      Paramecium bursar...
AAA67131      --------------------------------------------------------------------------------      Pyrococcus sp.
AAA72101      --------------------------------------------------------------------------------      Thermococcus lito...

AAB24152  795 ICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDKKPVSK-RSGAGDTDATLSGad-aTMQTkKKAAYAGGLVLEPMRG 872  fruit fly
P33609    775 IAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKpQQKLGDEDEEIDGdtnkYKKGrKKATYAGGLVLDPKVG 854  house mouse
P09884    771 IAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKpQQKLGDEDEEIDGdtnkYKKGrKKAAYAGGLVLDPKVG 850  human
P13382    780 LAGNAWAQTLGGTRAGRNEYILLHEFSRNGFIVPDKEGNRSrAQKQRQNEENADA----PVNS-KKAKYQGGLVFEPEKG 854  Saccharomyces cer...
P30320        --------------------------------------------------------------------------------      Paramecium bursar...
AAA67131      --------------------------------------------------------------------------------      Pyrococcus sp.
AAA72101      --------------------------------------------------------------------------------      Thermococcus lito...

AAB24152  873 LYEKYVLLMDFNSLYPSIIQEYNICFTTVQ------QPVDAD----ELPTLPDSKTEPGILPLQLKRLVESRKEVKKLMA 942  fruit fly
P33609    855 FYDKFILLLDFNSLYPSIIQEFNICFTTVQrvtsevQKATEDeeqeQIPELPDPNLEMGILPREIRKLVERRKQVKQLMK 934  house mouse
P09884    851 FYDKFILLLDFNSLYPSIIQEFNICFTTVQrvaseaQKVTEDgeqeQIPELPDPSLEMGILPREIRKLVERRKQVKQLMK 930  human
P13382    855 LHKNYVLVMDFNSLYPSIIQEFNICFTTVDr-----NKEDID----ELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMK 925  Saccharomyces cer...
P30320        --------------------------------------------------------------------------------      Paramecium bursar...
AAA67131      --------------------------------------------------------------------------------      Pyrococcus sp.
AAA72101      --------------------------------------------------------------------------------      Thermococcus lito...

AAB24152  943 ApDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQKMN--YDVVYGDT--DSL 1018 fruit fly
P33609    935 QqDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKDMVQKMN--LEVIYGDT--DSI 1010 house mouse
P09884    931 QqDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMN--LEVIYGDT--DSI 1006 human
P13382    926 T-ETDPHKRVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESMN--LLVVYGDT--DSV 1000 Saccharomyces cer...
P30320    590 ------------------------SVYGFLGASRGFIPCVPIAASVTATGRKMIEHTAKRVTELLpgSEVIYGDTdsVMI 645  Paramecium bursar...
AAA67131  493 ------------------------SYYGYYGYAKARWYCKECAESVTAWGREYIEFVRKELEEKFg-FKVLYIDT--DGL 545  Pyrococcus sp.
AAA72101  495 ------------------------SYYGYMGYPKARWYSKECAESVTAWGRHYIEMTIREIEEKFg-FKVLYADt--DGF 547  Thermococcus lito...

AAB24152 1019 MINTNITDY---DQVYKIGHNIKQSVNKLYK-QEELDIDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRR 1094 fruit fly
P33609   1011 MINTNSTNL---EEVFKLGNKVKSEVNKLYK-LLEIDIDAVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRR 1086 house mouse
P09884   1007 MINTNSTNL---EEVFKLGNKVKSEVNKLYK-LLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRR 1082 human
P13382   1001 MIDTGCDNY---ADAIKIGLGFKRLVNERYR-LLEIDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRR 1076 Saccharomyces cer...
P30320    646 RMKLPDDKIhdmDEQFKMAKWLAGEITKDFKaPNDLEFEKIYYPYILYSKKRYAAIKFEDPDEKG---KVDVKGLALVRR 722  Paramecium bursar...
AAA67131  546 YATIPGAKP---EEIKKKALEFVDYINAKLPgLLELEYEGFYVRGFFVTKKKYALIDEEG--------KIITRGLEIVRR 614  Pyrococcus sp.
AAA72101  548 YATIPGEKP---ELIKKKAKEFLNYINSKLPgLLELEYEGFYLRGFFVTKKRYAVIDEEG--------RITTRGLEVVRR 616  Thermococcus lito...