Conserved Protein Domain Family
SLC6sbd_NTT4
?
cd11521: SLC6sbd_NTT4 
Na(+)-dependent neurotransmitter transporter 4; solute-binding domain
NTT4 (also called XT1) transports the neutral amino acids, proline, glycine, leucine, and alanine, and may play an important role in synaptic transmission. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
?
Statistics
?
PSSM-Id: 271403
Aligned: 4 rows
Threshold Bit Score: 1177.07
Created: 20-Jul-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #                                                             
Q9H1V8        60 RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRL 139 human
XP_002196399  60 RPAWNSKLQYILAQIGYSVGLGNVWRFPYLCQKNGGGAYLVPYLVLLVIIGLPLFFLELAVGQRIRRGSIGVWNYICPRL 139 Taeniopygia gut...
XP_002933031  59 RPAWNNKLQYILAQIGYSVGLGNVWRFPYLCQKNGGGAYMVPYLILLIIIGIPLFFLELAVGQRIRRGSIGVWNYICPRL 138 western clawed ...
XP_417942     60 RPAWNSKLQYILAQIGYSVGLGNVWRFPYLCQKNGGGAYLVPYLVLLIIIGLPLFFLELAVGQRIRRGSIGVWNYICPRL 139 chicken

Feature 1                                                                                        
Q9H1V8       140 GGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPVVRNGSvaVVEAECEKSSATTYFWYREALDISDSISE 219 human
XP_002196399 140 GGIGYASCLVCFFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPVLRNGSvaVVETECERSSATTYFWYREALDISNSISE 219 Taeniopygia gut...
XP_002933031 139 GGIGYASCVVCFFVGLYYNVIIGWSIFYFFQSFQYPLPWNECPTVKNGSvnVVEAECDKSSATTFFWYREALDISNSISE 218 western clawed ...
XP_417942    140 GGIGYASCLVCFFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPIVRNGSvaVVETECERSSATTYFWYREALDISNSISE 219 chicken

Feature 1                                                                                        
Q9H1V8       220 SGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWR 299 human
XP_002196399 220 SGGLNWKMTLCLLVAWSLVGLAMIKGIQSSGKVMYFSSLFPYVVLVCFLVRGLLLRGAVDGIMHMFTPKLDKMLDPQVWR 299 Taeniopygia gut...
XP_002933031 219 GGGLNWKMTLCLLVAWTMVCMAMIKGIQSSGKVMYFSSLFPYVVLICFLIRGLFLRGSVDGILHMLTPKVEKMLDPQVWR 298 western clawed ...
XP_417942    220 SGGLNWKMTLCLLVAWSLVGLAMIKGIQSSGKVMYFSSLFPYVVLVCFLVRGLLLRGAVDGIMHMFTPKLDKMLDPQVWR 299 chicken

Feature 1                                                                                        
Q9H1V8       300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKaNIMNEKCVVENAEKILGYLN 379 human
XP_002196399 300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDATLVSFINFFTSVLATLVVFAVLGFKaNIMNEKCVVENAEKILGYLN 379 Taeniopygia gut...
XP_002933031 299 EAATQVFFALGLGFGGVIAFSSYNKQDNNCQFDAALVSFINFFTSVLATLVVFAVLGFKaNVMNEKCVVQNAEKILGYIN 378 western clawed ...
XP_417942    300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDATLVSFINFFTSVLATLVVFAVLGFKaNIMNEKCVVENAEKILGYLN 379 chicken

Feature 1                                                                                        
Q9H1V8       380 TNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWS 459 human
XP_002196399 380 TNVLSHDLIPPHVNFSHLTAKDYNEMYRVIMTVKEGHFKELGLDACLLEDELNKSVQGTGLAFIAFTEAMTHFPASPFWS 459 Taeniopygia gut...
XP_002933031 379 THDIDYSLIPPHVNFSHLTTEDYAKMYQVIKTVKEDHFQDLHLDACVLEDELDKAVQGTGLAFIAFTEAMTHFPASPFWS 458 western clawed ...
XP_417942    380 TNVLSHDLIPPHVNFSHLTAKDYNEMYRVIMTVKEGHFKELGLDACLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWS 459 chicken

Feature 1                 #  ##                                                                  
Q9H1V8       460 VMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILE 539 human
XP_002196399 460 VMFFLMLINLGLGSMIGTMSGITTPIIDTFKVRKEVFTVGCCIFAFVVGLIFVQRSGNYFVTMFDDYSATLPLTVVVILE 539 Taeniopygia gut...
XP_002933031 459 VMFFFMLINLGLGSMIGTMSGIITPIIDTFKVRKEILTVSCCIVAFLLGLIFVQRSGNYFVNMFDDYSATLPLTIVVILE 538 western clawed ...
XP_417942    460 VMFFLMLINLGLGSMIGTMSGITTPIIDTFKVRKEVFTVGCCIFAFVVGLIFVQRSGNYFVTMFDDYSATLPLTVVVILE 539 chicken

Feature 1                                                                                        
Q9H1V8       540 NIAVAWIYGTKKFmQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMA 619 human
XP_002196399 540 NIAVAWIYGTKKFmQELTEMLGFRPYQFYYYTWKYVSPICMAVLMTASIIQLGVSPPGYSAWIREEAAEKFLFYPTWAMA 619 Taeniopygia gut...
XP_002933031 539 NIAVAWVYGTKKFmQELTEMLGFRPYSYYFYSWKYVSPIFMAILLTASVIQLGISPPGYSAWIRELAAEQFVLYPTWALS 618 western clawed ...
XP_417942    540 NIAVAWIYGTKKFmQELTEMLGFRPYQFYYYTWKYVSPICMAVLMTASIIQLGVSPPGYSAWIREEAAEKFLFYPTWAMA 619 chicken

Feature 1                                     
Q9H1V8       620 LLITLIVVATLPIPVVFVLRHFHLLSDGS 648 human
XP_002196399 620 ILISLIILASLPLPLVFILRQFHLVSDGS 648 Taeniopygia guttata
XP_002933031 619 LLITLIILAILPVPVIFILWQFQLIPDGS 647 western clawed frog
XP_417942    620 ILISLIILASLPLPLVFILRQFHLVSDGS 648 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap