1O73,1I5G,1OKD


Conserved Protein Domain Family
TryX_like_family
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cd02964: TryX_like_family 
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Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are protein disulfide oxidoreductases containing an active site CXXC motif, similar to TRX.
Links
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Statistics
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PSSM-Id: 239262
Aligned: 33 rows
Threshold Bit Score: 138.129
Created: 8-Nov-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic residues [active site]
Evidence:
  • Structure:1I5G_A; Tryparedoxin bound to glutathionylspermidine; contacts at 3.5A
    - View structure with Cn3D
  • Comment:CXXC motif
  • Comment:based on known function of tryparedoxin
  • Comment:Tryparedoxin derives reducing equivalents from reduced trypanothione, a polyamine peptide conjugate unique to trypanosomatids.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #  #                                               
1O73_A        12 TNLLSKs-gEVSLGSLVGKTVFLYFSASWCPPCRGFTPVLAEFYEKHHVa------kNFEVVLISWDENESDFHDYYGKM 84  Trypanosoma bru...
1I5G_A        11 TNVLKGaaaDIALPSLAGKTVFFYFSASWCPPSRAFTPQLIDFYKAHAEk------kNFEVMLISWDESAEDFKDYYAKM 84  Crithidia fasci...
NP_503101     34 PMKKRGvdgNLPKDYFENKTVVVYFSAGWCGSCKFLTPKIKKFYNAVKEsda---gkNLEIVWVSKDKEAAHQEEYYEKN 110 nematode
NP_500578     11 LRLKDGt-mVDAGEHLKGKIVVLYFSASWCGPCRQFTPIMKELYQQIAAtn-----qPIEVILLSRDYMRFQLDEYYESH 84  nematode
NP_612463     17 QDELDTe--AEVSRRLENRLVLLFFGAGACPQCQAFVPILKDFFVRLTDefyvlraaQLALVYVSQDSTEEQQDLFLKDM 94  human
AAH71162       9 LLNKYGe-rVDPEEALQNKIVGLYFSASWCSPCRDFTPILCDFYTELVEese--ppaQFEIVFISSDKSPEEMVDYMHDM 85  African clawed ...
AAU20849      36 LEKRDKt-lVDATEALAGKAVGFYFSAHWCPPCRGFTPILKDFYEEVED--------EFEVVFVSFDRSESDLKMYMSEH 106 nematode
CAH71401      10 LVTCKGa-tVEAEAALQNKVVALYFAAARCAPSRDFTPLLCDFYTALVAear--rpaPFEVVFVSADGSSQEMLDFMREL 86  human
NP_001008630  10 LVNKEGd-lVEPEEALRNKVVGLYFSAGWCPPCRDFTPLLCDFYTELVEete--ppaQFEIVFISSDKSTEDMVEYYHDM 86  zebrafish
XP_423688     17 RDEVETe--RERCSALENRVMLLYFGAAECPRCQSFAPRLKDFFVRLTDefyverasQLCLVYVSRDATAQQEEAFLRSM 94  chicken

Feature 1                                                                        
1O73_A        85 --PWLALPFdqrstVSELGKtFGVESIPTLITINAdtGAIIGTQARTRVIe----dPDGANFPW 142 Trypanosoma brucei brucei
1I5G_A        85 --PWLALPFedrkgMEFLTTgFDVKSIPTLVGVEAdsGNIITTQARTMVVk----dPEAKDFPW 142 Crithidia fasciculata
NP_503101    111 lpDWPYIPFgdeniQKLSEK-YKAVVIPVLKLVNSn-GDVVHDRVRADVEagikadPVKTMEEW 172 nematode
NP_500578     85 gcSWGVVPLrdpiiEKCLEK-YDVKALPSCRVVDEf-GNCIDANARQSVEvnifenWRNVPESW 146 nematode
NP_612463     95 pkKWLFLPFed-dlRRDLGRqFSVERLPAVVVLKPd-GDVLTRDGADEIQr----lGTACFANW 152 human
AAH71162      86 qgDWLALPFhdpykHELKNK-YKITAIPKLVIVKQn-GDVITDKGRKQIRe----rGLSCFRTW 143 African clawed frog
AAU20849     107 g-DWYHIPYgndaiKELSTK-YGVSGIPALIIVKPd-GTEVTKDGRNDVQng--kdPKATVAKW 165 nematode
CAH71401      87 hgAWLALPFhdpyrHELRKR-YNVTAIPKLVIVKQn-GEVITNKGRKQIRe----rGLACFQDW 144 human
NP_001008630  87 hgDWLALPWtdpykHELKKR-YNITAVPKLVIVKEn-GQVITDKGRKQIRd----qGLACFRSW 144 zebrafish
XP_423688     95 prRWLSLPFrd-efKRELELrFVVSEVPRVVVLKPn-GDVIVGNAVDEITs----mGPACFQNW 152 chicken

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