Conserved Protein Domain Family
A2M_2

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cd02897: A2M_2 
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Statistics
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PSSM-Id: 239227
Aligned: 44 rows
Threshold Bit Score: 357.273
Created: 30-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:thioester region
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    ####                                                              
BAA86597  1129 TLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKtqqlspEVERETtdyLVQGYQRQLTYKRqDGSYSAFGERd-aSGS 1207 human
CAD24311   950 TMNNLGSLLRTPSGCGEQNMLGFAPDVFVTLYLHSagkldaATRAKAfkhFQTGYSNELNYKHrDGSFSAFGEGd-aSGS 1028 Ciona intestinalis
NP_598000  907 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKkkqltdNLKEKAlsfMRQGYQRELLYQReDGSFSAFGNYd-pSGS 985  human
BAD12264   940 SIEGLDKLVQMPYGCGEQNMINFAPNIYVLQYFEAikhpaaNIRRKAlsyMNSGYQRQLTYQHrDGSFSAFGEMd-eRGS 1018 inshore hagfish
CAG01462   864 SISGLDHLIRMPHGCGEQNMINFAPNVYVLQYLSAtgqadpETTARAtayMSTGYEQELTYQRaDGSFSAFGDSd-aAGS 942  Tetraodon nigrov...
XP_419879 1330 SINGLSSLIKMPYGCGEQNMINFAPNVYILQYLTKtrqlreDIQSKAlsfMRKGYQRELLFQRdDGSFSAFGNEd-pSGS 1408 chicken
XP_315149  725 VIHNLDSLLDVPSASGAPSMINFIPPLVVLDYLKAvsstttHLIEKAtglLRNGYQLELKYRQrDGSFGNWRDS---KGS 801  Anopheles gambia...
XP_317088  865 TIQNLDSLIRMPYGCGEQNMLNFVPNIVVLDYLKAtnkltaNIEAKAkkfMEAGYQRELGYKHrDGSFSAFGENd-kSGS 943  Anopheles gambia...
XP_784747  260 TMNNLDQLLRMPSGCGEQTMIGFAPDVFIYKYLTEtgqgnpTIEQKAlnyMKKGYQRELTYQHeDGSFSAWGGGsgdDGS 339  purple urchin
BAE44110   933 TISGLDSLLQMPTGCGEQTMLGLAPDVYVTDYLKSvnqltgDIKSKAlgyMESGYQRELTYKHkDGSFSAFGDSd-kSGS 1011 Euphaedusa tau
Feature 1                                                                                      
BAA86597  1208 MWLTAFVLKSFaqar--sfifVDPRELAAAKSWIIQQQQADGSFLAVGRVLNkdiqGGIHGIVPLTAYVVVALLETgtas 1285 human
CAD24311  1029 TWLTAFAAKCFmfarelrptlVSASVIDQALTFLINQQNTTGTFREPGRVSHkamqGGVDSPITMTAYVLITLKETnyav 1108 Ciona intestinalis
NP_598000  986 TWLSAFVLRCFlead--pyidIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHselqGGNKSPVTLTAYIVTSLLGYrkyq 1063 human
BAD12264  1019 TWLSAFVLKCFaqaq--ahmyIDKNLMKKTLNWLQSQRTPDGDYQELGHLLDssmlGASSGSVALTAYVVTSLMSSpkle 1096 inshore hagfish
CAG01462   943 TWLSAFVLRCFlqar--pfigVDAQVLEGVAAWLSTQQGAGGRFEESGRVIHtelkGGLEGPVSLTAYVLIALMEDpd-- 1018 Tetraodon nigrov...
XP_419879 1409 TWLSAFVLRCFfqar--pfidIDQDVLMDTAKWIVGHQKSNGEFQEPGKVLHsdlqGGTNNPITLTAYIMSSLLGFqdke 1486 chicken
XP_315149  802 VFVTALVGTSLeaask-hiteVDLTLVDRLFEWLAAKQHSSGRFDEEQPITYyslqGGSRNGIALTSFVLIAFLQNtkas 880  Anopheles gambia...
XP_317088  944 TWLTAFVARSFkqaa--nhitIDEGVIDKSLEWLSDHQAPNGSFPEVGVVSHkdmqGGSGSGVALTAYTLIAFLENinlv 1021 Anopheles gambia...
XP_784747  340 TFLTAFVVRSFlqaa--pyiyIDPAKMNQAITFLINHQNDNGSFMKSGRIVDqiidGGISSAETLTAYCAIAMDQVrtsd 417  purple urchin
BAE44110  1012 MWLTAFVTRVFhqak--ahiyIDDSIIITALQWMIGHQNSDGSFPEPGNVIHknmqGNAANGTALTIFVLISLLENhdll 1089 Euphaedusa tau
Feature 1                                                                                      
BAA86597  1286 e-------eergsTDKARHFLESAapl-amDPYSCALTTYALTllr------spaAPEALRKLRSLAImrdgvthwslsn 1351 human
CAD24311  1109 kn-----ravqeaAENARIYLENHltsisdNKYALAIVTYALHvagss---raneALLALEALATVQGgfkfwhdnsesp 1180 Ciona intestinalis
NP_598000 1064 ---------pnidVQESIHFLESEfsrgisDNYTLALITYALSsvg------spkAKEALNMLTWRAEqeggmqfwvs-- 1126 human
BAD12264  1097 v--------easnMLITMNYLEREfekgieDSRVLALVTYALIlgn------sskANSALDKLNSLATheggkmfwks-- 1160 inshore hagfish
CAG01462  1019 -----------lsVSGALGFLETRldlgisSNYSLSLVAYALAlan------ssrAPLALQELMGRAElkdgvplwss-- 1079 Tetraodon nigrov...
XP_419879 1487 ---------hayvIKRATNFLEDKlkegisDNYTLALVTYALSwak------stkAKEALSMLNERAErqgefrfwit-- 1549 chicken
XP_315149  881 a-------qhrsiIEKGIQYVANQles-iaDVYDLSLATYALMlad------hrqKSSALNKLIELGIatne-------- 938  Anopheles gambia...
XP_317088 1022 d-------kykntINKAIDYVYRNtes-ldDTYALALAAYALQlad------hssKGLILSKLDTKATtdsdskwwhkpi 1087 Anopheles gambia...
XP_784747  418 ilsdttkstantaLTNAMNYLVSRytviqeDKYAMAIVTYALAlggspstpqfltRLNELQTVEDEGRlkywtdqdeqtt 497  purple urchin
BAE44110  1090 vntnaagylldqaAAKALAYSEKAvan-tdDLYILAMAAYAFQlag------stqTQAVLTKLEQKASvkdgskywhqve 1162 Euphaedusa tau
Feature 1                                                                                   
BAA86597  1352 swdvdkgtflsfsdrvsqSVVSAEVEMTAYALLTytllgdvaaALPVVKWLSqQRNALGGFSSTQDTCVALQALAEY 1428 human
CAD24311  1181 ------dsyssrwrpyyyNPPTNDIEMSAYALLTyvrrndlnaGIPVMKWLAsKRSSLGGYSGTQDTVIAIQALSKV 1251 Ciona intestinalis
NP_598000 1127 ---------sesklsdswQPRSLDIEVAAYALLShflqfqtseGIPIMRWLSrQRNSLGGFASTQDTTVALKALSEF 1194 human
BAD12264  1161 --------asveepkwhwQPSASGVETAAYALLAnfklhraeeGVPIMRWLGqQRNHLGGFVSTQDTVVALEAMSEF 1229 inshore hagfish
CAG01462  1080 --------peagrsrsswQPRSADIEMASYVLLShhklgliaeGVKLMKWLSqQRNDRGGFRGTQDTVVALQALATL 1148 Tetraodon nigroviridis
XP_419879 1550 ---------paseisdswQPRSIDIELAAYALLShfhqdrleeGIPIMKWLSqQRNHLGGFSSTQDTVVALQALSLF 1617 chicken
XP_315149  939 --------------trywPRDTASIETTAYALLSlvhakryadGLMVMHWLVnQQSATGSFPRTQDTFVGIRALAAL 1001 Anopheles gambiae s...
XP_317088 1088 -------peteqknpwysRPNSVNVEMSAYGMLAfleagldtdALPIMKWLIgQRNDKGGFQSTQDTVVGLQALAKL 1157 Anopheles gambiae s...
XP_784747  498 ------pasdefyyrvwrGPPSAAIEMTGYGMLAylarndvvgSIPVAGWLSqQRNSLGGYSSTQDTVIALLALTTY 568  purple urchin
BAE44110  1163 a-----pkttnlgwespnPTQAVGTEITSYVLLTyaaqgdlvkAKNVIQWITkQRNPHGGFQSTQDTVVALFAMSQF 1234 Euphaedusa tau

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