Conserved Protein Domain Family
RHOD_ThiF
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cd01526: RHOD_ThiF 
Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein 3 (MOCS3) of Homo sapiens. These rhodanese-like domains are found C-terminal of the ThiF and MoeZ_MoeB domains.
Links
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Statistics
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PSSM-Id: 238784
Aligned: 13 rows
Threshold Bit Score: 163.634
Created: 29-Jun-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site residue [active site]
Evidence:
  • Comment:Site-directed mutagenesis showed that this conserved Cys is required for sulfurtransferase activity, and is postulated to form a persulfide during catalysis.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
AAC24520  424 ADILSPEERISPSEYGNVdsa------gaqRHIIDVREKVQFDICSLENSINIPMSTIlasaysaptldadepk---rlp 494 Emericella nidulans
O95396    327 LQLLSPEERVSVTDYKRLlds------gafHLLLDVRPQVEVDICRLPHALHIPLKHLerrdaeslkllkea-------i 393 human
AAH71459  327 LHLLSREQRVSVQDYKGIldh------stpHLLPDVRPKVEVDICRLSNSLHIPLASLedkkpehitllkea-------i 393 zebrafish
S62465    293 SKQLAPIRRISALDLKNLiet------sphITFLDVREPVQFGICRLPLFKNIPLSEVdslq------------------ 348 fission yeast
EAA54778  355 VALLKSEERVSAEQLNALlqqqa--gehgkPVLLDVREREHFEIANIPGAINIPFSKTqnpgarhnaedtp--------k 424 Magnaporthe grisea...
XP_385204 325 VQLLKPDERVTPKEYEMIsksg-----dkeTLLVDVREKEHFDLCNISGSINIPISRFmsargettpe------------ 387 Gibberella zeae PH-1
NP_501359 283 LKLLELSDRVNVTEYRNKrre-------qkPVLLDTRPSLEFEIAHLPEAINVTLKECrslsaedisn------------ 343 nematode
Q9ZNW0    338 LNLLPAESRISSKEFKEIlqk------keqHVLLDVRPSHHYKIVSLPDSLNIPLANLetrlneltsalke--------k 403 thale cress
EAK94830  320 FDPIDDKFRVSPKDYDSVvqn------kkkHILIDVRPREQFQITHLPNAINVQWDPTfrkadaieq------------- 380 Candida albicans S...
P38820    316 YNVCEPDERISVDAFQRIykdde---flakHIFLDVRPSHHYEISHFPEAVNIPIKNLrdmngdlkkl------------ 380 baker's yeast
NP_609240 336 MLLLSTDERLSVEDYQQKiqa-------qpHLLIDVRPTAEFEICQLPEAVNVPLVEIlddsylkrl------------- 395 fruit fly
XP_324916 341 KGVLSEEERITPREFVERvqgkdgngkgkkYVVLDTREKEHFSFGSIEGAVNLPFGKLlskaaqlkrsgetpkvgdilpp 420 Neurospora crassa
Q09810    293 SKQLAPIRRISALDLKNLiet------sphITFLDVREPVQFGICRLPLFKNIPLSEVdslq------------------ 348 fission yeast

Feature 1                       #                                                
AAC24520  495 swlppevahesnKPIYVVCRqGNDSQTVVRKLKElgldh-ggerpVVDIKGGFRSWREQVDPDWPDY 560 Emericella nidulans
O95396    394 weekqgtqegaaVPIYVICKlGNDSQKAVKILQSlsaaqeldpltVRDVVGGLMAWAAKIDGTFPQY 460 human
AAH71459  394 sdlqehlnnqspVQVFVVCKlGNDSQKAVQLLEKmsgae-veamtVKDISGGLMAWAKKIDHCFPQY 459 zebrafish
S62465    349 ---------nlsGKVCVICRsGNTSQTAVRKLQElnp-----qadIFDVVAGLKGWSTEVDPNFPLY 401 fission yeast
EAA54778  425 ldwlpdgvadghSPVYVVCRvGNDSQTVARQLKEfgldn-qgkrfIGDVKGGMLAWKREVDSTLPFM 490 Magnaporthe grisea 70-15
XP_385204 388 ---gwpsdlspsTPIYLVCRvGNDSQIAAQKLKTlgigk-ngerfIGDISGGIKSWKDTVDPTVPFI 450 Gibberella zeae PH-1
NP_501359 344 ---rlglqntehSDVFVICHrGNDSQRAVLLLREklv-----dikFRDIIGGYEQWALKINDMFPLY 402 nematode
Q9ZNW0    404 gnghantesctnPSVFVVCRrGNDSQRAVQYLREsgf------dsAKDIIGGLEAWAANVNPNFPTY 464 thale cress
EAK94830  381 ---ylpddstkdDEIYVVCRfGNDSQLAAKKLIGmgy------pnVRDIIGGLDKWSDDVDSKIPKY 438 Candida albicans SC5314
P38820    381 --qeklpsvekdSNIVILCRyGNDSQLATRLLKDkfg-----fsnVRDVRGGYFKYIDDIDQTIPKY 440 baker's yeast
NP_609240 396 ----gkqledkeLPIVLVCRrGNDSQIAVQHLRNrfp-----thfVRDLIGGLHAWTNSVDPSFPIY 453 fruit fly
XP_324916 421 eiqvrdghgdkdIPIYVVCRrGLDSQEAVEKLKEmgldn-ggsrkIVDIAGGMKAWKEQVDPSFPYL 486 Neurospora crassa
Q09810    349 ---------nlsGKVCVICRsGNTSQTAVRKLQElnp-----qadIFDVVAGLKGWSTEVDPNFPLY 401 fission yeast

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