1JDI,4FUA,1GT7


Conserved Protein Domain Family
Aldolase_II
?
cd00398: Aldolase_II 
Click on image for an interactive view with Cn3D
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.
Links
?
Statistics
?
PSSM-Id: 238232
Aligned: 13 rows
Threshold Bit Score: 221.855
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the active center contains a metal ion (usually zinc) stabilizing the reaction intermediates.
  • Structure:4FUA; PGH (phosphoglycolohydroxamate) and Zn2+ bound
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        #                                          ## 
1JDI_A       3 EDLKR----QVLEANLALPKHNLV-----TLTWGNVSAVDrer---------------------------gvFVIKPSGV 46   Escherichia coli
4FUA         4 NKLAR----QIIDTCLEMTRLGLN-----QGTAGNVSVRYqd-----------------------------gMLITPTGI 45   Escherichia coli
1GT7_A       7 SWFVQ----GMIKATTDAWLKGWD-----ERNGGNLTLRLddadiapyhdnfhqqpryiplsqpmpllantpFIVTGSGK 77   Escherichia coli
1169774      4 AELSQ----KIIDTCLEMTKLGLN-----QGTAGNVSVRYkd-----------------------------gMLITPTGM 45   Haemophilus infl...
1353059     14 CHPAN----LICTLCKQFFHNNWC-----TGTGGGISIKDpnt---------------------------nyYYLAPSGV 57   baker's yeast
586722       3 EQLKA----DVLAANLALPAHHLV-----TFTWGNVSAVDetr---------------------------qwMVIKPSGV 46   Escherichia coli
543774     130 ERLMRc---KISSVYRLLDLYGWAql-sdTYVTLRVSKEQd------------------------------hFLISPKGV 175  human
12644023   116 EKILRc---KLAATFRLLDLYGWT-----QGLGAQITARLkvd--------------------------qeyFLVNPYGL 161  fruit fly
732032       2 QKLKQ----QVFEANMELPRYGLV-----TFTWGNVSAIDrer---------------------------glVVIKPSGV 45   Escherichia coli
1168481      3 AQLKK----EVFEANLALPKHHLV-----TFTWGNVSAIDrek---------------------------nlVVIKPSGV 46   Haemophilus infl...
CAC89189     7 SWFIQ----GMIKATSDMWHKGWD-----ERNGGNISLRLlaeevepyrrdfyqqprkveltqpapelanswFLVTGSGK 77   Yersinia pestis ...
NP_215241    1 MNFVDapesAVLAAAKDMLRRGLV-----EGTAGNISARRsd----------------------------gnVVITPSSV 47   Mycobacterium tu...
12644231   142 EKLLRc---KLAAFYRLADLFGWSqliynHITTRVNSEQEh-------------------------------FLIVPFGL 187  human

Feature 1                                              ###                              # #    
1JDI_A      47 DYSIMT---ADDMVVVSIe------tGEVveg----akKPSSDTP-------THRLLYQAFPs-----IGGIVHTHSRHA 101  Escherichia coli
4FUA        46 PYEKLT---ESHIVFIDGn-------GKHee-----gkLPSSEWR-------FHMAAYQSRPd-----ANAVVHNHAVHC 98   Escherichia coli
1GT7_A      78 FFRNVQldpAANLGIVKVdsd---gaGYHilwgltneaVPTSELP-------AHFLSHCERIkatngkDRVIMHCHATNL 147  Escherichia coli
1169774     46 PYHLMK---TENIVYVDGn-------GKHee-----nkLPSSEWQ-------FHLSVYHTRPe-----ANAVVHNHSIHC 98   Haemophilus infl...
1353059     58 QKEKMI---PEDLFVMDAqtleylrsPKLy--------KPSACTP-------LFLACYQKKN------AGAIIHTHSQNA 113  baker's yeast
586722      47 EYDVMT---ADDMVVVEIa------sGKVveg----skKPSSDTP-------THLALYRRYAe-----IGGIVHTHSRHA 101  Escherichia coli
543774     176 SCSEVT---ASSLIKVNIl-------GEVv-------eKGSSCFPvdttgfcLHSAIYAARPd-----VRCIIHLHTPAT 233  human
12644023   162 LYHEIT---ASALNKVDMq-------GQIv-------eQGTTNFGgnkshfvLHSVVHAARPd-----IRCAIYIGCSPV 219  fruit fly
732032      46 AYETMK---AADMVVVDMs-------GKVveg----eyRPSSDTA-------THLELYRRYPs-----LGGIVHTHSTHA 99   Escherichia coli
1168481     47 DYDVMT---ENDMVVVDLf------tGNIveg----nkKPSSDTP-------THLELYRQFPh-----IGGIVHTHSRHA 101  Haemophilus infl...
CAC89189    78 FFRNVElnpAENLVLLQVsnd---gmAYHihwgltqggLPTSELA-------AHFQSHIVRMqvsggtNRVIMHCHATNL 147  Yersinia pestis ...
NP_215241   48 DYAEML---LHDLVLVDAg-------GAVlhak--dgrSPSTELN-------LHLACYRAFDd-----IGSVIHSHPVWA 103  Mycobacterium tu...
12644231   188 LYSEVT---ASSLVKINLq-------GDIv-------dRGSTNLGvnqagftLHSAIYAARPd-----VKCVVHIHTPAG 245  human

Feature 1                                                                                      
1JDI_A     102 TIWAQAgq------------sIPATGTTHAdy--------fyGTIPCTRKMtdaei-----ngeyEWETGNVIvetfekq 156  Escherichia coli
4FUA        99 TAVSILnr------------sIPAIHYMIAaa--------ggNSIPCAPYAtf-----------gTRELSEHValal--- 144  Escherichia coli
1GT7_A     148 IALTYVlendta----vftrqLWEGSTECLvv--------fpDGVGILPWMvp-----------gTDEIGQATaqem--- 201  Escherichia coli
1169774     99 AGLSILek------------pIPAIHYMVAvs--------gtDHIPCVPYAtf-----------gSHKLASYVatgi--- 144  Haemophilus infl...
1353059    114 VICSLLfgdefrianieqikaIPSGKVDPVtkkpmalsffdtLKIPIIENMa------------hEDELIDDLhktfk-- 179  baker's yeast
586722     102 TIWSQAgl------------dLPAWGTTHAdy--------fyGAIPCTRQMtaeeingeyeyqtgEVIIETFEergrs-- 159  Escherichia coli
543774     234 AAVSAMkw-----------glLPVSHNALLv-----------GDMAYYDFNgem--------eqeADRINLQKclg---- 279  human
12644023   220 VAISSLkt-----------glLPLTKDACVl-----------GEITTHAYTglf---------deEERNRLVRslg---- 264  fruit fly
732032     100 TAWAQAgl------------aIPALGTTHAdy--------ffGDIPCTRGLseeevqgeyelntgKVIIETLGnaep--- 156  Escherichia coli
1168481    102 TIWAQAgl------------dIIEVGTTHGdy--------fyGTIPCTRQMttkeikgnyeletgKVIVETFLsrgie-- 159  Haemophilus infl...
CAC89189   148 IALSYVqklena----sftrlLWEGSTECLvv--------fpDGIGIVPWMvp-----------gTDGIGTQTaeqm--- 201  Yersinia pestis ...
NP_215241  104 TMFAVAhe------------pIPACIDEFAiy--------cgGDVRCTEYAasg---------tpEVGRNAVRale---- 150  Mycobacterium tu...
12644231   246 AAVSAMkc-----------glLPISPEALSl-----------GEVAYHDYHgil--------vdeEEKVLIQKnlg---- 291  human

Feature 1                    #                                                         
1JDI_A     157 gidaaqmPGVLVHSHGPFAWGKNAEDAVHNAIVLEEVAYMGIFCRqlapqlpdmqqtLLNk-----hYLRKH 223  Escherichia coli
4FUA       145 ----knrKATLLQHHGLIACEVNLEKALWLAHEVEVLAQLYLTTLaitdpvpvlsdeEIAv-----vLEKFK 207  Escherichia coli
1GT7_A     202 ----qkhSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYsmggmkqtisreELIa-----lGKRFG 264  Escherichia coli
1169774    145 ----kesKAILLAHHGLITCGENLDKALWLAQEVEVLASWYLKLLstgleipllskeQMQv-----vLGKFH 207  Haemophilus influenzae
1353059    180 --dypdtCAVIVRRHGIFVWGPTIDKAKIFNEAIDYLMELAIKMYqmg------ippDCGi-----gEEKKH 238  baker's yeast
586722     160 ---paqiPAVLVHSHGPFAWGKNAADAVHNAVVLEECAYMGLFSRqlapqlpamqneLLDk-----hYLRKH 223  Escherichia coli
543774     280 ----ptcKILVLRNHGVVALGDTVEEAFYKIFHLQAACEIQVSALssagg--venliLLEq-----eKHRPH 340  human
12644023   265 ----pnsKVILLTNHGALCCGETIEEAFFAACHIVQACETQLKLLpvgl----dnlvLIPe-----eSRKAI 323  fruit fly
732032     157 ----lhtPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMAWIARginpqlnhidsfLMNk-----hFMRKH 219  Escherichia coli
1168481    160 ---pdniPAVLVHSHGPFAWGKDANNAVHNAVVLEEVAYMNLFSQqlnpylspmqkdLLDk-----hYLRKH 223  Haemophilus influenzae
CAC89189   202 ----rehSLVLWPFHGIFGSGPTLDDAFGLIDTAEKSAEIMVKVLsmggkkqtisreQLIa-----lAARFD 264  Yersinia pestis CO92
NP_215241  151 -----grAAALIANHGLVAVGPRPDQVLRVTALVERTAQIVWGARalggpv-pipedVCRnftgvygYLRAN 216  Mycobacterium tuberculos...
12644231   292 ----pksKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLasagg--pdnlvLLNp-----eKYKAK 352  human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap