1GYF


Conserved Protein Domain Family
GYF

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cd00072: GYF 
Click on image for an interactive view with Cn3D
GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
Links
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Statistics
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PSSM-Id: 238027
Aligned: 21 rows
Threshold Bit Score: 65.7912
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
proline bindingproline
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:proline binding motif
Evidence:
  • Comment:GYF; conserved residues in the binding site, GPY[or F]xxxxM[or V]xxWxxxGYF
  • Citation:PMID 9843987

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #################                            
1GYF_A      1 DVMWEYKWEntgdAELYGPFTSAQMQTWVSEGYFPDGVYCRKLd-pPGGQFYNSKRIDFDLY 61   human
AAL39272  260 EVTWEFKWSqd-eTDIQGPFSTEKMLKWSQENYFKNGVYVRKCg--ENTNFYTSNRIDFDLY 318  fruit fly
NP_081629 281 DVMWEYKWEntgdAELYGPFTSAQMQTWVSEGYFPDGVYCRKLd-pPGGQFYNSKRIDFELY 341  house mouse
7491139   386 LLHWLYKDPq---NNVQGPFTGVDMHQWYRAGYFPLGLPIKRL---EEEEYYSLAFFIRQVG 441  fission yeast
4544404   193 EKIWHYKDPs---GKVQGPFSMAQLRKWNNTGYFPAKLEIWKAn-eSPLDSVLLTDALAGLF 250  thale cress
4406809   434 NMVWLYGDPd---GKIHGPFSLYNLRQWNSSGHFPPELRIWRLg-eQQHSSILLTDALNGQF 491  thale cress
417787    255 ESSWRYIDTq---GQIHGPFTTQMMSQWYIGGYFASTLQISRLg--STPETLGINDIFITLG 311  baker's yeast
6325152   149 ESQWKYIDSn---GNIQGPFGTNNMSQWYQGGYFTPTLQICRLa--TSPEPFGVNDRFIRLG 205  baker's yeast
NP_499184 395 DITVFYTDDr---GTVQGPYGASTVLDWYQKGYFSDNHQMRFTd--NGQRIGNLFTYETTLG 451  Caenorhabditis elegans
NP_508224   7 ELEIFYIDDe---DNVQGPYGAKHVLGWYRNGHFHDDHQFKIVdcaQHGELVTYEAYLGDLK 65   Caenorhabditis elegans

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