1XZQ,2GJ9,3GEH,3GEE


Conserved Protein Domain Family
trmE
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cd04164: trmE 
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trmE is a tRNA modification GTPase
TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.
Links
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Statistics
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PSSM-Id: 206727
Aligned: 134 rows
Threshold Bit Score: 131.077
Created: 28-Jun-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 # ####                                                              
1XZQ_A    241 NRGLRMVIVGKPNVGKSTLLNRLLNEDRAIVTDIPGTTRDVISEEIVIrGILFRIVDTAGVRSETNd------------l 308 Thermotoga maritima
3GEE_A    231 SEGVSTVIAGKPNAGKSTLLNTLLGQERAIVSHMPGTTRDYIEECFIHdKTMFRLTDTAGLREAGEe------------- 297 Chlorobaculum tepidum
NP_651251 237 RDGVRTVIIGAPNVGKSSLLNLLCQRSVSIVTDQAGTTRDIIETMHNFgGYPVVFSDTAGLRRYTTd------------s 304 fruit fly
AAH95801  246 RSGVHVVIAGSTNAGKSSLLNLLTQRPAAIVSPTAGTTRDVLEVPLDIgGYPVLLSDTAGLRDTSDs------------- 312 zebrafish
XP_757505 322 STGIHLALYGPPNAGKSSLLNRLADRNAAIVSDIPGTTRDVLQVHLDLaGYKVIVYDTAGMRDESQlahgsd--qpslde 399 Ustilago maydis 521
CAG00759  214 RSGVQVVIAGATNAGKSSLLNTLCQRPAAIVSPIAGTTRDVVETPLDIgGFPVLLSDTAGLRDSLDl------------- 280 Tetraodon nigrovir...
AAK39557  247 RSGAHVVVTGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLaGFPVLLSDTAGLREGVGp------------- 313 human
EAN31378  274 VDGIKLLLLGPTNSGKSSFINNLFNDDISIVSNIPGTTRDLIRVNYNLdGLNYQITDSAGINNRILdgdtnatesldndt 353 Theileria parva
CAI76094  262 VDGIKLLLLGPTNSGKSSFINNLFNDDISIVSNIPGTTRDLIRVNYNLnGLNYQIIDSAGINNRILdgitnwsessdcda 341 Theileria annulata
XP_646629 244 RDGANIAIVGPPNAGKSSLINLLTNRKASIVSPIAGTTRDIVEVILDIdGYPVIIGDTAGLRNSTNd------------q 311 Dictyostelium disc...

Feature 1                                                                                     
1XZQ_A    309 VERLGIERTLQEIEKADIVLFVLDAss----------pLDEEDRKiler------------------------------- 347 Thermotoga maritima
3GEE_A    298 IEHEGIRRSRMKMAEADLILYLLDLgt---------erLDDELTEirelka----------------------------- 339 Chlorobaculum tepidum
NP_651251 305 IEQEGMQRAKNCLVQSDLILLLAEAkn---------iaQLTHDDAvapfvdsylge------------------------ 351 fruit fly
AAH95801  313 VEQEGVRRARQRVEQADLSLVVVDLtqlp-----serrHVPVFLRghlknil---------------------------- 359 zebrafish
XP_757505 400 IERIGIRRAKDAVSNADLALLVLPAh-----------qASACDAQyilrph----------------------------- 439 Ustilago maydis 521
CAG00759  281 VEREGVRRARERLEQADLTLVVVDCallp-----shqpEAAGFLKrhlrsvls--------------------------- 328 Tetraodon nigrovir...
AAK39557  314 VEQEGVRRARESCNFLATVVASVGA-------------QSPSDSSq---------------------------------- 346 human
EAN31378  354 IELIGIKKALNEIETSNVILFLFDPvnvn-----dsfsSLQLFLNllneikifyshtcnslsntttpsipvtdtegnisd 428 Theileria parva
CAI76094  342 IELIGIKKALDQIETSNVILFLFDPlnvn-----dslsSLHLLLNllnkakipscnvtnsintitpfg--ftdtdnglpd 414 Theileria annulata
XP_646629 312 IEIEGIEMAKDRFNNSDIKLFLFDSfnlfsqlnqnqnlNSSFNFNeeiknl----------------------------- 362 Dictyostelium disc...

Feature 1                       ## #                                    ###                   
1XZQ_A    348 --------iknkRYLVVINKVDvvekineee-------------iknklgtdrHMVKISALkg--------egLEKLEES 398 Thermotoga maritima
3GEE_A    340 -------ahpaaKFLTVANKLDraanadali-------------raiadgtgtEVIGISALng--------dgIDTLKQH 391 Chlorobaculum tepidum
NP_651251 352 -ldipldmcsgkRLQLVANKTDtltdeeh-----------------qqldklsNVLAISCHkpdk----mpvfLGSLEKQ 409 fruit fly
AAH95801  360 -----erssqqqQHILILNESDlvsaeqqrsiq----------tslqelsgapSACFLSCHsr--------dgLEELLTL 416 zebrafish
XP_757505 440 ------sythtdRDLIFYNKSDllga-----------------------sspsSCAPTSCSitwqgsvhtnhnIPNLISD 490 Ustilago maydis 521
CAG00759  329 ----lqehpergRVLLVLNKTDllphperqnla----------relarasglpPVCLISCHtg--------egLQDFLAA 386 Tetraodon nigrovir...
AAK39557  347 ------------RLLLVLNKSDllspegp-----------------gpgpdlpPHLLLSCLtg--------egLDGLLEA 389 human
EAN31378  429 hdhhglngvckkLVYVCINKTDlienvnyyknai--------ldflnnykaknTNGAKSTVlfe-------dnLKILENT 493 Theileria parva
CAI76094  415 ntqqnsgsdckkLVYVCINKSDliedvgfykki----------ifdflntevkNTNGESKKldf------ednFKILQNT 478 Theileria annulata
XP_646629 363 ------fnfidnETIIIFNKSDllkqfdnlkewenlklnlldnikksnnlnsiQSIEISCNnn--------enIKDLLNL 428 Dictyostelium disc...

Feature 1           
1XZQ_A    399 IYRETQ 404 Thermotoga maritima
3GEE_A    392 MGDLVK 397 Chlorobaculum tepidum
NP_651251 410 LQELCG 415 fruit fly
AAH95801  417 LHNTLK 422 zebrafish
XP_757505 491 LAHLIA 496 Ustilago maydis 521
CAG00759  387 LHSSVR 392 Tetraodon nigroviridis
AAK39557  390 LRKELA 395 human
EAN31378  494 NLDRNV 499 Theileria parva
CAI76094  479 NLDRNV 484 Theileria annulata
XP_646629 429 LKLNLK 434 Dictyostelium discoideum

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