1J8C


Conserved Protein Domain Family
hPLIC_N
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cd01808: hPLIC_N (this model, PSSM-Id:176403 is obsolete and has been replaced by 340506)
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Ubiquitin-like domain of hPLIC-1 and hPLIC2
hPLIC-1 and hPLIC-2 (human homologs of the yeast ubiquitin-like Dsk2 protein) are type2 UBL's (ubiquitin-like) proteins that are thought to serve as adaptors that link the ubiquitination machinery to the proteasome. The hPLIC's have an N-terminal UBL domain that binds the S5a subunit of the proteasome and a C-terminal UBA (ubiquitin-associated) domain that binds a ubiquitylated protein.
Links
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Statistics
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PSSM-Id: 176403
Aligned: 7 rows
Threshold Bit Score: 122.191
Created: 8-May-2010
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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S5a binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:S5a binding site
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                         #  #   # #### #                # ###
1J8C_A     33 IKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKS-QTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIK 103 human
XP_393540  11 ITVNVKTPKEKQSIEIEEDASIKDFKEAISKKFNA-QTEQLCLIFAGKIMKDHETLSTHNVKDGLTVHLVIK 81  honey bee
NP_998521  26 IKVTVKTPKDKEEIAIAEDASVAQFKEEISKRFKA-KQDQLVLIFAGKILKDGDTLGQHGIKDGLTVHLVIK 96  zebrafish
AAF49003    9 INVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEA-EPEQLVLIFAGKIMKDTDTLQMHNIKDNLTVHLVIK 79  fruit fly
AAH42257   19 IRVTVKTPKDKEEIVIGETACVIEFKEEISRRFKA-KRDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIK 89  African clawed frog
XP_313568  25 ITIMVKTPKDRKSIEIEDDAEIKDLKAIVAEKFET-NQELVCLIFAGKIMKDTDTLKTHNIKEGLTVYLVIK 95  Anopheles gambiae str. PEST
NP_740883   8 IKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTaNKEQVCIIYTGKILKDEETLTQHKIADGHTVHLVIR 79  nematode

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