Conserved Protein Domain Family
Ig2_FGFRL1-like
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cd05856: Ig2_FGFRL1-like (this model, PSSM-Id:143264 is obsolete and has been replaced by 409442)
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)
Ig2_FGFRL1-like: second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1). FGFRL1 is comprised of a signal peptide, three extracellular Ig-like modules, a transmembrane segment, and a short intracellular domain. FGFRL1 is expressed preferentially in skeletal tissues. Similar to FGF receptors, the expressed protein interacts specifically with heparin and with FGF2. FGFRL1 does not have a protein tyrosine kinase domain at its C terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.
Links
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Statistics
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PSSM-Id: 143264
Aligned: 6 rows
Threshold Bit Score: 151.139
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
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FGF bindingligand binding
Feature 1:FGF binding site [polypeptide binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # # #                                                                         
NP_989787    151 RRVIARPVGSSIRLKCVASGnPRPDITWLKDnkplmpheiGENKkkkWTLNLKNLKPEDSGKYTCRVFNkVGEINATYKV 230 chicken
CAH03196     158 RRVLEQPVGSSVRLKCLASGnPTPVITWWKDqsll--dnpQQSKrpqWTLTLKNLQPQDSAKYTCHVSNaAGHINATYKV 235 zebrafish
BAD18794     127 RRVIARPVGSSVRLKCVASGhPRPDITWMKDdqaltrpeaAEPRkkkWTLSLKNLRPEDSGKYTCRVSNrAGAINATYKV 206 human
NP_956670    151 KRVIARPVGSSVRLKCTASGnPRPDIVWLKDsrpltpeevGEGRkkkWTLSLKNLTPEHSGKYTCHVSNrAGEINATYKV 230 zebrafish
NP_001086420 151 KRVIARPVGSSVRLKCIASGnPRPDITWLKDnkpltsqeiGDNKkkkWTLNLKSLKPEDSGKYTCQVYNrVGQINATYKV 230 African clawed ...
XP_783945    186 AQKIMKPLNSSVRLKCKASGhPRPEIVWEKDgtrmvitegRQSRq--FTLKLSHLKPGDSGTYMCIVFNkHGRINATYEV 263 purple urchin

Feature 1          
NP_989787    231 EV 232 chicken
CAH03196     236 DV 237 zebrafish
BAD18794     207 DV 208 human
NP_956670    231 EV 232 zebrafish
NP_001086420 231 EV 232 African clawed frog
XP_783945    264 DV 265 purple urchin

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