3WUH,4K25


Conserved Protein Domain Family
ASKHA_NBD_OSGEPL1_QRI7_euk
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cd24134: ASKHA_NBD_OSGEPL1_QRI7_euk 
nucleotide-binding domain (NBD) of O-sialoglycoprotein endopeptidase-like protein 1 (OSGEPL1) and similar proteins from eukayotes
The family includes mammalian OSGEPL1 and yeast QRI7, which are the mitochondrial orthologs of the universal Kae1/ TsaD (also known as YgjD) protein. OSGEPL1/QRI7 (EC 2.3.1.234), also called mitochondrial tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein, or tRNA threonylcarbamoyladenosine biosynthesis protein, is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. It is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. It is involved in mitochondrial genome maintenance.
Links
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Statistics
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PSSM-Id: 466984
Aligned: 60 rows
Threshold Bit Score: 348.356
Created: 23-Jan-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:
  • Comment:The active site is located in a cleft between domains I and II of N-terminal domain (NTD) of YgjD/Kae1/Qri7 family proteins.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ##                                                                      
3WUH_B      11 VLAIETSCDDTCVSVLDrf------sKSAAPNVLANLKDTLdsi--------deGGIIPTKAHIHHQARIGPLTERALIE 76  Saccharomyces cer...
4K25_A      11 VLAIETSCDDTCVSVLDrf------sKSAAPNVLANLKDTLdsi--------deGGIIPTKAHIHHQARIGPLTERALIE 76  Saccharomyces cer...
P43122      35 VLAIETSCDDTCVSVLDrf------sKSAAPNVLANLKDTLdsi--------deGGIIPTKAHIHHQARIGPLTERALIE 100 Saccharomyces cer...
O94710      41 ALAIETSCDDTSVSVVRtsdssshcqNEIICLNTHRTISKYea----------yGGIHPTIVIHEHQKNLAKVIQRTISD 110 Schizosaccharomyc...
RPA86394    34 TLGIETSCDDTSVAILR---------GEVYPDSTRSEKISLvyhktitssnriyGGVHPIVSLESHQHNLAPLIKDALSS 104 Ascobolus immersu...
GAO47270    23 CLAIETSCDDTCVALLRqptp--dspCEIISNLTHRSLHLHeq----------yGGLHPLVSVHSHIQNLSRLIRQTVDA 90  Saitoella complic...
GAC73858    40 ILGIETSCDDSCASVVAs-------dRTILSSVVTKQDHSSf------------AGIHPLAAALGHHTNLPSTIAAALDE 100 Moesziomyces anta...
KAA1474343  34 VLGIESSADDTGVAIVTs-------nAKILANVVKKQHLVHen----------yGGIHPYVAVQTHQKNLARAVKEALEQ 96  Dentipellis sp. K...
KNE97419     9 LLGIESSCDDSCASIVSs-------eRRILSNIRLSQNQIHkp----------fEGIHPYHAIHAHQINLPIAIGKALQQ 71  Puccinia striifor...
TIC10107    17 ILALESSADDTCAAVVSs-------hREILSNVVLKQNNIHeq----------yGGIHPLYAVQGHMMNIPQAINDALRL 79  Wallemia mellicola

Feature 1                                                     #   #                            
3WUH_B      77 sna---reGIDLICVTRGPGmPGSLSGGLDFAKGLAVAWnKPLIGVHHMLGHLLIprmgtn------gkvpqFPFVSLLV 147 Saccharomyces cer...
4K25_A      77 sna---reGIDLICVTRGPGxPGSLSGGLDFAKGLAVAWnKPLIGVHHXLGHLLIprxgtn------gkvpqFPFVSLLV 147 Saccharomyces cer...
P43122     101 sna---reGIDLICVTRGPGmPGSLSGGLDFAKGLAVAWnKPLIGVHHMLGHLLIprmgtn------gkvpqFPFVSLLV 171 Saccharomyces cer...
O94710     111 aars-gitDFDLIAVTRGPGmIGPLAVGLNTAKGLAVGLqKPLLAVHHMQAHALAvqle---------ksidFPYLNILV 180 Schizosaccharomyc...
RPA86394   105 in-----tKPDLIAVTRGPGmGAALSVGLDTANGLAACMdIPIVGVHHMQAHALTprlhyglnnrtndirpsFPFLTLLV 179 Ascobolus immersu...
GAO47270    91 hirgpdgiKVDLVAVTRGPGmQGCLAVGMSHARALAAAWgCKYIGVHHMQAHALTprlvss------gkgpeFPYFTLLL 164 Saitoella complic...
GAC73858   101 asi--qasDLDAIAVTQGPGmASSLGVGLTAAKTLSAVLrKPLIYVHHMQAHALTpllte-------eeppqFPFLVLLV 171 Moesziomyces anta...
KAA1474343  97 anm--ratDVDGIAFTRGPGmTGCLGVGSSAARTLAAALsKPLVGVHHMQAHALTplltsp-----pssrpqFPFLTLLV 169 Dentipellis sp. K...
KNE97419    72 adl--kltDLHGIAYTRGPGiAGCLAVGATAAKTLSISTgIPLIAVHHMQAHALTpllts-------dqpirFPFLSLLV 142 Puccinia striifor...
TIC10107    80 snl--slnDMDAIATTQGPGmPGCLQIAIVAAKALAGASnKPLIGVHHMQAHALTctlte-------ktppeFPFYTLLC 150 Wallemia mellicola

Feature 1                                        #                                             
3WUH_B     148 SGGHTTFVLSRaidDHEILCDTIdi---aVGDSLDKCGRELgfk----gtMIAREMEKFINQDIndqdfalklem----- 215 Saccharomyces cer...
4K25_A     148 SGGHTTFVLSRaidDHEILCDTIdi---aVGDSLDKCGRELgfk----gtXIAREXEKFINQDIndqdfalklex----- 215 Saccharomyces cer...
P43122     172 SGGHTTFVLSRaidDHEILCDTIdi---aVGDSLDKCGRELgfk----gtMIAREMEKFINQDIndqdfalklem----- 239 Saccharomyces cer...
O94710     181 SGGHTMLVYSNsllNHEIIVTTSdi---aVGDYLDKCAKYLgi------pWDNEMPAAALEQFAspeinstsyslk---- 247 Schizosaccharomyc...
RPA86394   180 SGGHTILLESTgltEHKLLAASQni---aVGDCLDKAARELlpkeqwggdGGHVAYGKILEDFAfpngeadwnfyhppgt 256 Ascobolus immersu...
GAO47270   165 SGGHTQLVHSKsltDHTVLTDAYisnslsIGCLFDRTAKALev------kWDGKMPGAALEKWSwgtdpdpeypmteeea 238 Saitoella complic...
GAC73858   172 SGGHTMLVLATsitEFRILATTSdd---sIGDAFDKVARDLg-------iPWTSAPGAALEALAakhagassid------ 235 Moesziomyces anta...
KAA1474343 170 SGGHTLLLLATsvsDFRILASTPde---aVGRVFDKVSRMLcl------pWSKLGPGAALEEFClddvdgtapav----- 235 Dentipellis sp. K...
KNE97419   143 SGGHTMLVLVNstnEFKILANTAdk---pIGLAIDKISRALdip----wpEGPISPGSALEKFVqqshsevki------- 208 Puccinia striifor...
TIC10107   151 SGGHTMIVDSEsvhKMSILATSHdd---sIGNAFDQAAKLLnip---wslHPSNAPGAALEVFAdqenikanevvli--- 221 Wallemia mellicola

Feature 1                                                                                      
3WUH_B     216 -------------------psplknsaskrNMLSFSFSAFITALRTNLTKlgkteiq------elpereIRSIAYQVQES 270 Saccharomyces cer...
4K25_A     216 -------------------psplknsaskrNXLSFSFSAFITALRTNLTKlgkteiq------elpereIRSIAYQVQES 270 Saccharomyces cer...
P43122     240 -------------------psplknsaskrNMLSFSFSAFITALRTNLTKlgkteiq------elpereIRSIAYQVQES 294 Saccharomyces cer...
O94710     248 -------------------ppiplntrekvHSASFSFSGLESYACRIIRKtpln------------lseKKFFAYQLQYA 296 Schizosaccharomyc...
RPA86394   257 aerdarteslggslydfrlsapltqkdrhlKLMAFSFTGLGTSVERIVRKegie------------eglKQAVARELFVA 324 Ascobolus immersu...
GAO47270   239 --------------kwkitpplnkpkhtsrKGQEFSLTGIEAWLFRLLKRrreaavaeglepqpleleeGKGMARAIQRT 304 Saitoella complic...
GAC73858   236 ---------------------pptfplpckGQPAFSYSGLKAAVQRHIEAhqaal----------ddasKSAIAHAFQSA 284 Moesziomyces anta...
KAA1474343 236 --------------------evptlpgampSVLGFSFSGLHSAVERFVTAngggea--------ldvptKRALAREFQRA 287 Dentipellis sp. K...
KNE97419   209 ---------------------eplpvalrtGPSVFSFCGLQTATVRRLHPlst-------------vdeKRAIGKEFLNA 254 Puccinia striifor...
TIC10107   222 ------------------keyrkklrvpapGQLLFSYSGLRSAFGRLVEEsdkt------------emtRKALARAFQAA 271 Wallemia mellicola

Feature 1                                                                                      
3WUH_B     271 VFDHIINKLKHVLksqpe------------------kfknvREFVCSGGVSSNQRLRTKLETELgtln---stsfFNFYY 329 Saccharomyces cer...
4K25_A     271 VFDHIINKLKHVLksqpe------------------kfknvREFVCSGGVSSNQRLRTKLETELgtln---stsfFNFYY 329 Saccharomyces cer...
P43122     295 VFDHIINKLKHVLksqpe------------------kfknvREFVCSGGVSSNQRLRTKLETELgtln---stsfFNFYY 353 Saccharomyces cer...
O94710     297 AFQHICQKTLLALkrld--------------------lskvKYLVCSGGVARNELLKKMLNDTLmvlqfehqptdIKLVY 356 Schizosaccharomyc...
RPA86394   325 AFEHLAKRIHMALekmge------------------rakegIPLVVSGGVASNRFLRHLLRVYFdskg----yskVELLF 382 Ascobolus immersu...
GAO47270   305 AFKHVMTQVLLRLeevt---------------------ptpTSMVVSGGVASNMFLRTYLRQSLdaag----fkeVQLVF 359 Saitoella complic...
GAC73858   285 ACAQLEDKLSMVLrpssaiedargrkfprialeepgfsdriTAIVCSGGVASNHFLRARLRTHLdtlg----rrdVQLQF 360 Moesziomyces anta...
KAA1474343 288 AVAQLEEKVQLGFdfcrr------------------kgfevRHVVVSGGVASNSYLRERLRIRMeqas---pdvpIALVF 346 Dentipellis sp. K...
KNE97419   255 AFAQLERKISYWFkqld--------------------hlylSGLVISGGVGSNLILRSRIKTLLeti-----dpkLQLYI 309 Puccinia striifor...
TIC10107   272 AVAQLKDKIELALdnap---------------------skpSSLVVSGGVASNGYLRKSLTELTer-------qnMSIYF 323 Wallemia mellicola

Feature 1             #               
3WUH_B     330 PPMdLCSDNSIMIGWAGIEIWES 352 Saccharomyces cerevisiae S288C
4K25_A     330 PPXdLCSDNSIXIGWAGIEIWES 352 Saccharomyces cerevisiae S288C
P43122     354 PPMdLCSDNSIMIGWAGIEIWES 376 Saccharomyces cerevisiae S288C
O94710     357 PSPdICSDNAAMIGYTAIQMFKA 379 Schizosaccharomyces pombe 972h-
RPA86394   383 PPPaLCTDNAAMIAWAGLEMYGA 405 Ascobolus immersus RN42
GAO47270   360 PPVnLCTDNAPMIGWAGMEMWRD 382 Saitoella complicata NRRL Y-17804
GAC73858   361 PPLsLCTDNAAMIAWVGHLIYHQ 383 Moesziomyces antarcticus T-34
KAA1474343 347 PPPsLCTDNAAMIAWASMPRFLA 369 Dentipellis sp. KUC8613
KNE97419   310 PPVeLCTDNAAMVAWLGLDKLNR 332 Puccinia striiformis f. sp. tritici PST-78
TIC10107   324 PAPsLCTDNAAMIAWAAHYKLAN 346 Wallemia mellicola

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