6NR8


Conserved Protein Domain Family
Prefoldin_3

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cd23156: Prefoldin_3 
Prefoldin subunit 3
Prefoldin subunit 3 is one of the alpha subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.
Statistics
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PSSM-Id: 467472
Aligned: 138 rows
Threshold Bit Score: 109.484
Created: 4-Mar-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:prefoldin oligomer interface [polypeptide binding site]
Evidence:
  • Comment:forms a hexamer composed of two alpha and four beta subunits
  • Structure:6NR8; Homo sapiens prefoldin complex, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #  ##  ## ##               ######## ##########     #
6NR8_3         4 KLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMqkkk------estnSMETRFLLAdNLYCKASVPPt---DK 74  Homo sapiens
XP_001707972  52 ALQEKLQKYSFMLDVVQKQKNSLVGSTADLRENLDLIDYLekq---------esAFEARYELAaGVYAKAMIPKs---DQ 119 Giardia intesti...
TNJ28771      43 SLQETLGKYNLMLDALRKQRDGLRASTAELRENLDAISHLqdrf------eeasEVDVRYELAaGVYARARIPRt---DR 113 Giardia muris
XP_024506982  44 KLQNDYRKYKILESEMKALKEKITENLPDYEQAKQVINFLkmkk------anneTLKTSYKLTdEVYQHAEVEDl---DS 114 Strongyloides r...
XP_011134460  58 AYDEIHGKFKLMTSSLNDQLVTLEEREGHLKEALDVIRGAktr---------ktNTETLYKVAdCLYTRARVTEp---QK 125 Gregarina nipha...
KKA02280      39 NVQQNLQKYEYMLKSKDQQLKSITDITKDIKTNSKVIDTLiaqnaddsddedgeFQDIQYELEdGLFAFASIPKksttNT 118 Hanseniaspora u...
XP_002061055  51 LENAKYAKYGQLAMQLEHNYTNQTIRIETAKSNLQLVRKFmed---------ktEFEAKFQPAiGVFTTVIVPPl---EK 118 Drosophila will...
XP_030388044  51 VLTEKYSNYGELALKLEPSYAEQQINIEMTKANLKLIKKFqee---------kiEFMTRVQLFnKVYKDVFVPPv---ES 118 Scaptodrosophil...
OAO12222      50 VCEVLQKRFSNMMANVGSTRDLLLTSVSKIKDEIKVLEMLiqkr------deeeQVKNMFNMApLLFVDAVIPPq---NK 120 Blastocystis sp...
XP_001975092  50 LQRCFYVQYSELAAKLETDLTAVLSRLEAAKNNLELVRKFmdn--------pgeELQSLMQIAqGVFRWVTIPPv---ER 118 Drosophila erecta
Feature 1        ####   ######        #                                    
6NR8_3        75 MCLWLGANVMLEYDIDEAQALLEKNLSTATKNLDSLEEDLDFLRDQFTTTEVNMARVY 132 Homo sapiens
XP_001707972 120 VSLWLGSHVMVEFPHGEARSLLKKNLGDAEQSIAEMAKNLQFIKEQITMIEVSISRVF 177 Giardia intestinalis
TNJ28771     114 ISLWLGSGVMVEYPPEEARALLSKNLAEADAAITDLEQNIQFLKEQATTTEVCISRVF 171 Giardia muris
XP_024506982 115 FVLYMGAYVMVEYPLDEGEEFINKNIAAINQRISEIDEELEYILNQITIVEVSTAHFI 172 Strongyloides ratti
XP_011134460 126 CFLWLGSNVMMEYTPEEAEAVVGKNLATTKENIEDILENILALRSETTVIEASISRLH 183 Gregarina niphandrodes
KKA02280     119 VSLWLGSGILMEFTYEEAQQILSEKSAVYTNKINEIMEDIEFLREQITTLQVNMSKVY 176 Hanseniaspora uvarum DSM 2768
XP_002061055 119 VNLLVGSNVFMEFELKDAEKHLIGQIKDLVQQLKAYEHDVEYLREMMVITELNISRLY 176 Drosophila willistoni
XP_030388044 119 VTIVIPGNVHMQFPLDEAEKYVIKQLGQMVQQLKIYEHDLNYLRDQMSTTNLNITRVY 176 Scaptodrosophila lebanonensis
OAO12222     121 CYVKLSSTVIVEMTLDEALEFSKDKLDRLKKNEESFTKQFNFLRDQMTILTLNMNRAY 178 Blastocystis sp. ATCC 50177/Nand II
XP_001975092 119 VTLQVGTSLQMEFDLPEAEEFIKKDITGLVKQRVQHEHDIDYLQDQVNTVEMNLAVLY 176 Drosophila erecta

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