6SWG


Conserved Protein Domain Family
TASOR_PBD

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cd22569: TASOR_PBD 
Click on image for an interactive view with Cn3D
periphilin binding domain of protein TASOR and similar proteins
TASOR, also called CTCL tumor antigen se89-1, retinoblastoma-associated protein RAP140, or transgene activation suppressor protein, is a component of the HUSH complex, a multiprotein complex that is at least composed of TASOR, PPHLN1 and MPHOSPH8, and mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. This model corresponds to a conserved region of TASOR, which is responsible for the binding of periphilin.
Statistics
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PSSM-Id: 439336
Aligned: 38 rows
Threshold Bit Score: 88.0049
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
periphilin
Conserved site includes 39 residues -Click on image for an interactive view with Cn3D
Feature 1:periphilin binding site [polypeptide binding site]
Evidence:
  • Structure:6SWG; Homo sapiens TASOR in complex with periphilin homodimer, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # ### ##  ##  ## ##  ##  ##  # ########                   # #####  ## ##  ##  ##
6SWG_C          2 SETTERTVLGEYNLFSRKIEEILKQKNvsYVSTVSTPIFSTqekmKRLSEFIYSKtsKAGVQEFVDGLHEKLNTIIIKAS 81   human
KFV11531      921 SAIIETTLLEEYNLFARKIQEILQQKNiaYVSGMSTPVFSAqermMRLSEYICLQasEVSVQEYIETLSEKLNSVILSSS 1000 red-crested t...
XP_028906380 1001 RGTIKNIMLEEYNIFSRKTEEFLRQHNipNVKRLSTSTFSAqgraLKFSKYMYSQgsDVGVQQYVNSLHEKLNDIVTMAT 1080 platypus
XP_029456778  767 SGVIETAVLEEYSLFSRKIQDVLKINNiaYTSSKTTPVLSTqegvLQLSEHLSLQasEISVKQYVEQLHEKLADVIASIS 846  two-lined cae...
XP_014349851  806 TGIIENTVFKEYGEFCSKIQAILEQKNvlHDIKMTAPVFSFqerlTGLSKYVNSHtsHIAVQQHVENLREKMNNLISSVL 885  coelacanth
NP_001086537  468 NGLIENTVLEIYNTFSEQLHDVLKQRDvpYMVPATPPLLSSddrvLKLSDCLYEQasDICVQQYVDDLHIKLDNVVAIHI 547  African clawe...
PIO31552       99 NGVIESTVQEIYSSFSERLQEVLREKDiaYTAVTAPVLSSDek-dVRLSDWLYARtsSIPVQQYIDELRVKLDSVVNSYL 177  American bull...
XP_007888724  893 ASVIENMVLLEYNTFANKMRQLLKKEKvrYSAEKKQPTFSTpskvPSLSRFASVCtrDVAVQNYVSQLRKKMNCVVADAC 972  elephant shark
XP_020391836  881 ASAIENAVLSEYSKFSDKMKQLLKKEKvrYGSDNKKPIFLAprkvPALSRYSNVQshQVSVQSYINKLRKRMNSVIADAC 960  whale shark
GCF43018      937 SEIIEKAILDEYKHFTSKIQETLQQKNimYVSGISKPVFSAkeriMRLSQYICLQasDIAVQEYIEGLSEKLNKVALSSY 1016 Paroedura picta
Feature 1           
6SWG_C         82 AK 83   human
KFV11531     1001 CI 1002 red-crested turaco
XP_028906380 1081 PY 1082 platypus
XP_029456778  847 FC 848  two-lined caecilian
XP_014349851  886 PV 887  coelacanth
NP_001086537  548 NS 549  African clawed frog
PIO31552      178 SS 179  American bullfrog
XP_007888724  973 SH 974  elephant shark
XP_020391836  961 SD 962  whale shark
GCF43018     1017 GN 1018 Paroedura picta

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