Conserved Protein Domain Family
AKR_AKR13B1
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cd19088: AKR_AKR13B1 
AKR13B family of aldo-keto reductase (AKR)
Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Links
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Statistics
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PSSM-Id: 381314
Aligned: 38 rows
Threshold Bit Score: 186.269
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ###                                   #    #                              
AAF84538   19 VNRLGFGAMRItgpdvw--gepedHDEAIRVLKRLPEIG-VDLIDTADSYGPfv------------sEQLIADALHPYg- 82 
NP_696194  26 IPRLGMGTMALaieg-----rpsnRDQAIETIHAALDAG-VRYLDTAWSYYLpsapgtgepedmgygEYLVRDALHSWhg 99  Bifidobacterium lo...
KXK57926   13 VNAIGYGAMHLsidra----rrplEADSVRLIQHAVDQLgVNFIDTADAYCIddte-------tghnERIIAEALRDPdr 81  Chlorobi bacterium...
PIP81794   13 LFPIGLGGMPLsiqg------rpdEAQALRVIGASLDAG-VAFIDSADVYCLdqtd-------ighnERLIAKALKARgr 78  Elusimicrobia bact...
SCA58815   13 LSSIGLGAWLLsekg------rptEENAIEVIHSSLNQG-VNLIDTANAYCLndte-------ighnERLIKKALESWke 78  Chlamydiales bacte...
KGA09548   14 IPALGIGGMPFsrp-------grdLDESISIIHFGLNHG-MTLLNTADVYAPsaee-------mghnEKLMGEALRQWdg 78  actinobacterium ac...
AOY55890    8 KKHIGFGFMNAswpgsavliddhaKAKFIEVLQYALDQG-ITFFDTADIYAPswda-------mghnEKLLAEAVAGWag 79  Candidatus Rhodolu...
SFH21887   10 VGQVALGGVTFslgp------drkRSGDIATIRAAADAG-IRIFDSARVYAPvddp--------qhnERLFAHALKGRs- 73  Streptomyces
EGB11956  163 VSRVGFGTLALgvlyp---dgrppEDAAVSIVRAALARG-CTFFDTADCYCAdggd-------thyaERLLARALGDAda 231 Aureococcus anopha...
KSU54722   25 VSRLALGGARLtagdgw--gvprdLEVPRGILRAALEAG-IDHIDTADALGPav------------sEQIIGDVIGDRd- 88  Microbacterium sp....

Feature 1                 #                                               ##                  
AAF84538   83 ------GIKIATKGSLVRypgnstn--pswpvigDPAYLRQCVYMSLRRLkLEQIDLWQLHRIDPk----vPRAEQFGAI 150
NP_696194 100 p---kdQVLVATKTGWLRtldgngn--ygwqadaRPETMIANAKESARRLgVDTLDLLYSHCNDPq----vPYEDQMGAL 170 Bifidobacterium lo...
KXK57926   82 ----raRVTVATKGGSIRpegrw-------erngRPEHLRAACERSLTALgAEIIDLYQLHAPDPt----vPVEESVGAL 146 Chlorobi bacterium...
PIP81794   79 ----tkSVTVATKGGLKRpngdw-------trdaSPAQLRAACEASLKALqSDSITLYQLHAVDPa----vALEESVGEL 143 Elusimicrobia bact...
SCA58815   79 ----thSVYVATKGGCTRpdgaw-------grngKKQHLLEACKKSLEDLgIDQIFLYQLHGPGSn----cPFEESIEAL 143 Chlamydiales bacte...
KGA09548   79 d---qsKVIVVTKNGITRskdqw-------nrngSKEYLLRAAEKSNKEL-GMVPDLLLHHRIDQs----rSFTEQAQAM 143 actinobacterium ac...
AOY55890   80 tleqkrQLVIATKGGITRsegev------wgrnaSPAYLVSVAEQSAKNLnLDVIPVWQHHRLDPt----rTFSQALQGL 149 Candidatus Rhodolu...
SFH21887   74 ------DVLISTQGGHFRtgqet------wdvdnSAARLRQDVAASLDALgVERIGLYYLHRADAp----hPIGESVSVL 137 Streptomyces
EGB11956  232 -----gSVVVSTKGGNRRrgdgreskswafghriAAAEVRPAIAASRAALgRRHPMIWSLHNTDSfepegpDFADILRAM 306 Aureococcus anopha...
KSU54722   89 ------DVLVATKVGMLRpgpge------wgvlgRPDYLRQQVHASLFRLrRERIDLVYLHRIDPd----yPLADQLGAL 152 Microbacterium sp....

Feature 1                   ##                        #                                       
AAF84538  151 REFIDEGLIRHAGLSQVsvEAIEEARKv------fPVATVQNRYNLADRAde-------------dVLDYCEANgIGFIP 211
NP_696194 171 KQLVDEGVAKAVGISRIdnADIETARNil----gdRLVAVQNQFSPVHRDpe-------------hTLETCEKLgLAFVC 233 Bifidobacterium lo...
KXK57926  147 RDLQREGKIAQIGVSNFsvPLLERARRe------aDIATVQNQFSVINQRee------------eaMVRFCEQNtITYIP 208 Chlorobi bacterium...
PIP81794  144 KKLQDEGKILHIGLSNVdlGELERAEKi------aRIESVQNRCSPYDREdyd-----------dgLLAACEERgITFLP 206 Elusimicrobia bact...
SCA58815  144 AELKQKGLVKYLGLSNVslEQLNQAQAv------tRIESVQNCFNLYSTEdlt-----------ngLIKACEAQrVTYIA 206 Chlamydiales bacte...
KGA09548  144 LAVLNAGLTKKIGFSNIkqSEYEIAQQet----hgQVSAVENERSPRYRSdv-------------eVLESCTKDqIAYLA 206 actinobacterium ac...
AOY55890  150 LAVKNSGLAKNIGVSNYnaNQVRAAFDllggpedgGLVSVQNQLNPAYIHdl-------------dVLDVCEELgLAFLP 216 Candidatus Rhodolu...
SFH21887  138 DEMRREGKIQRIGLSNVtaAQLEEAHSi------tSIDAVQNHHGVAHADss-------------gVLRLCEKLsIPFFA 198 Streptomyces
EGB11956  307 RDANDAGDCDALGLSNAsaRHVDAAAAvl----gdRLVAVQNELSFFATQafkprkpnaaksnkagVVAACAAAgVAFVA 382 Aureococcus anopha...
KSU54722  153 QQLQTQGLIGHIGVSQPtaSQLEDVLAle-----pDLAAVQSLYNVAARGda-------------eLARTLEVRgIPFLA 214 Microbacterium sp....

Feature 1     #######                          #                 ######  #  ##         
AAF84538  212 WFPLAAGDlakpggav------dalakakGATAGQIALAWLLKRs-PVILPIPGTSKVAHLEENVAAAAITLS 277
NP_696194 234 WSPLGGFLdpfnehlfd---rfrevakihDCSYQRVTLAWELAQy-QYLFTIPSARNPQEIQDSFKASELKLS 302 Bifidobacterium longum NC...
KXK57926  209 WNPVGGRGkapqlaelsa--llaelaathGTTPHVVAIAWLLQLs-PAMLPIPGTTKIEHLEENMTAATLQLT 278 Chlorobi bacterium OLB7
PIP81794  207 YGPVGGHRahtrlldep---llaslaekyEATPYTIVLAWHLAKs-ERILPIPGASKIASAEDSPKAALLDLE 275 Elusimicrobia bacterium C...
SCA58815  207 YSPVGSRPkhvdmtkge---llqklslkyKVSSYQVLLAWVLHLs-KNMIAISGSTRVESAEDSPKAMGLSLE 275 Chlamydiales bacterium SC...
KGA09548  207 WSPLGGENdaknlgtlyp--efkevardlEVTAQQVALAWLRTHs-NVLVPIPGFTKIKTAESTIASADLTLS 276 actinobacterium acAMD-5
AOY55890  217 WSPMKGARqteagtpsye--algklatqrGVSRFEVTSGWLRGLt-PNLVIMPGVTRKESIDNSLKGLEFVLS 286 Candidatus Rhodoluna plan...
SFH21887  199 YYPLRRDDgrpysegfp---rmgalaadrVISLARLLLRALLESs-PVMSVVSGASRAESAMDSAAALTEVWD 267 Streptomyces
EGB11956  383 FGVFGGLParqhkrdvaaleplrrvaeraGASPHAVVLKWLLHRhpAGFVALAGTRRADRVPDVAAVEDLILA 455 Aureococcus anophagefferens
KSU54722  215 YWPLLGRGiaadrhralf-eglasiggplGLDGPQVALAWIFSTl-PGAGAVVGSRSAAHLRSNARSAGLRLD 285 Microbacterium sp. NIO-02

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