3V0U,3V0T


Conserved Protein Domain Family
AKR_AKR13A_13D
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cd19076: AKR_AKR13A_13D 
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AKR13A and AKR13D families of aldo-keto reductase (AKR)
Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Links
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Statistics
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PSSM-Id: 381302
Aligned: 32 rows
Threshold Bit Score: 441.655
Created: 25-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3V0T: Rauvolfia serpentina perakine reductase in complex with 2'-monophosphoadenosine-5'-diphosphate, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #                                                            
3V0U_A      3 PRVKLGTqgLEVSKLGFGCMGLsgdynd----alpeeqGIAVIKEAFNCGiTFFDTSDIYGen------------gsNEE 66  serpentwood
3V0T_A      2 PRVKLGTqgLEVSKLGFGCMGLsgdynd----alpeeqGIAVIKEAFNCGiTFFDTSDIYGen------------gsNEE 65  serpentwood
Q09923      4 PTRKIGN--DTVPAIGFGCMGLhamygp-----sseeaNQAVLTHAADLGcTFWDSSDMYGfg-------------aNEE 63  fission yeast
EIE19339    8 PEKSLGTqgFSGSIQGYGCMSLtafgap-----ekaegAEQTLKHVLEQGvTLLNTATFYGqn-------------lNEE 69  Coccomyxa subellip...
EKX35269    2 ELRPLGSqgLMAPPMGLGCMGMtafydvn--hdeheeiSLRTLDRALELGvNFLVSKGFAScg-------------rNEE 66  Guillardia theta C...
CDF35760    2 RTIALGSqgLVISKIGYGCMGLttaygt----klpdddIVALLEKTHELGiTLWDTANLYVypdffrllrfssplvcQEE 77  carragheen
KRX04333    9 PRKVLGNtkTEVSRIGYGCMGLsafyttd---pipeeqGIEIIGKAIEQGqNFFDTAYIYGd---------------NEK 70  Pseudocohnilembus ...
OQS04340    7 QARKLGSqgLEVSKIGLGAMGMtafyggdfdreaaeetNINTIGKALELGiNFIDTAWIYQsfgadg-----kpnrtNEE 81  Thraustotheca clavata
PNW76476    8 PVGALGKsgVSAPRLGYGCMSLsnnlyag---apseedAIKLLHRAYELGvRLFNTSDLYGpy-------------tNEQ 71  Chlamydomonas rein...
OUS44823    3 AKRRIGD--REVYPVGLGCMNIthaygp----pmdeaeAKGLLVRALDLGyDFLDTATLYGfg-------------rSEE 63  Ostreococcus tauri

Feature 1                                                                                     
3V0U_A     67 LLGKALKql-pREKIQVGTKFGIheigfsg--vkakgtPDYVRSCCEASLKRLdVDYIDLFYIHRIDtt---vPIEITMG 140 serpentwood
3V0T_A     66 LLGKALKql-pREKIQVGTKFGIheigfsg--vkakgtPDYVRSCCEASLKRLdVDYIDLFYIHRIDtt---vPIEITMG 139 serpentwood
Q09923     64 CIGRWFKqtgrRKEIFLATKFGYeknpetg-elslnnePDYIEKALDLSLKRLgIDCIDLYYVHRFSge---tPIEKIMG 139 fission yeast
EIE19339   70 IIGSVIKef-pRERVKITTKWGPtwrdgq---lkhdgsREHCRAECFSSLKRLgVDYLDMFIFRGPPda--ntPWEDTIQ 143 Coccomyxa subellip...
EKX35269   67 LVGKAIKkh-gRDKFIIATKFGAeytadak-pvphlgrPEHVRRHCEDSLKRLgTDYIDLYYMHRMDpt---tPIEETMG 141 Guillardia theta C...
CDF35760   78 IISRAIEkv-gRENIQIATKTGVelrlfpklrivpngsPSFIRQQCEDSLRRLkTDYLDLFYLHRIDqt---lPIEISMM 153 carragheen
KRX04333   71 LLGKAIKkf-gRDKFFLATKFPAmlikgqe-rvknpgtVENIKEYCRQSLERLdIDQIDLYYAHRVDse---iPIEKQVE 145 Pseudocohnilembus ...
OQS04340   82 LVGKAIKrf-gRDRFVIATKFGItmcdgs---mavsgkPEFVRQQLHESLDRLgIDQIDLYYMHRMDps---tPIEETVA 154 Thraustotheca clavata
PNW76476   72 LLAKAFPad-aYPDVVFATKWGAqfvpgqg--ivndnsRGNCRKCCEGALSRLqRPHLDLYTYRGPPstaagvSIADTME 148 Chlamydomonas rein...
OUS44823   64 LIGQALKd--rRDSYFLASKCVLgfdggq---rtldarPESIKAACEASLKRLqTDVIDLYYMHRPDpn---vPIEDSVG 135 Ostreococcus tauri

Feature 1                                                                         ####  #     
3V0U_A    141 ELKKLVEEGKIKYVGLSEAsPDTIRRAHAvhPVTALQIEYSLWTRDIed---eIVPLCRQLgIGIVPYSPIGRGLFWGKA 217 serpentwood
3V0T_A    140 ELKKLVEEGKIKYVGLSEAsPDTIRRAHAvhPVTALQIEYSLWTRDIed---eIVPLCRQLgIGIVPYSPIGRGLFWGKA 216 serpentwood
Q09923    140 ALKKCVEAGKIRYIGLSECsANTIRRAAAvyPVSAVQVEYSPFSLEIerpeigVMKACRENnITIVCYAPLGRGFLTGAY 219 fission yeast
EIE19339  144 FMKELVEEGHVKYLGLSEVsPADIRRAHAihPITALEMEWSLFSRDAee---dLVPTARELgIGFLAYSPLGRGLLTGAL 220 Coccomyxa subellip...
EKX35269  142 EVKKLIAEGKVKYVGLSECtAAELRAAHAvqPISAIQMEWSLQTRDIek---dIVPTARELgVAIVAYSPLGRGLLSNTF 218 Guillardia theta C...
CDF35760  154 EMKKLVEEGKVKYVGLSECsASTIRRAHRihPITAVQLEYSLWCRDIet---gIMPTCAELgIGVVAYSPLGRGFFGGST 230 carragheen
KRX04333  146 GFKQLIEEGKIRFYGLSEAsEDSIRRAHKyyPLTAVQEEFSLQTRDIee--ngVLKACKELgIAVVAYSPIGRGLLTGAV 223 Pseudocohnilembus ...
OQS04340  155 CLKELVDEGKIKYIGLSECsSDELRRAHAvhPISAIQMEWSLNSRDAek---tVIKTARELgVGIVAYSPLGRGLLTGKI 231 Thraustotheca clavata
PNW76476  149 ECKLLLAEGKIRGVGLSEVsAEQVRQAAAvvPIAAVELEWSLFTRDAed---eIIPTCRELgIAILAYSPLSRGLLTGAV 225 Chlamydomonas rein...
OUS44823  136 ALSDLVQEGKIRMIGLSEMgEADLRRAHAvhPIAAMQSEYSLWVRNPei---aIKAACEELgVALVAFSPVGRGFLADPP 212 Ostreococcus tauri

Feature 1                                                  #                      #####  #  ##
3V0U_A    218 IKEslpens--vltshPRFVGENLEKNKQIYYRIEALSQKHgcTPVQLALAWVLHQg-----eDVVPIPGTTKIKNLHNN 290 serpentwood
3V0T_A    217 IKEslpens--vltshPRFVGENLEKNKQIYYRIEALSQKHgcTPVQLALAWVLHQg-----eDVVPIPGTTKIKNLHNN 289 serpentwood
Q09923    220 KSPddfpeg-dfrrkaPRYQKENFYKNLELVTKIEKIATANniTPGQLSLAWLLAQg-----dDILPIPGTKRVKYLEEN 293 fission yeast
EIE19339  221 KSKedvpeq--argfnPRMAGEHFDKNAKLVQNVVQLAAKKgvTPGQLALAWVTQQg-----dDVIPIPGTKRVACVDEN 293 Coccomyxa subellip...
EKX35269  219 KSRsdiken-dwrrfnPRFSEENFDTNYQNTLKIKAVAERKgcTPAQIALAWLLHQg-----kDVFPIPGTKSPERLEEN 292 Guillardia theta C...
CDF35760  231 GTTkkyslt-dfranqPRFVGEAAEGNAKLLENVQKIADQKgvSTAQLTLAWVEAQghrlngaGIVAIPGTTKEKNLISN 309 carragheen
KRX04333  224 KSTselektdfrqslaPRFQGENLQKNVQQVEELKKIAVELkvTPSQLALAWLLHKg-----dNIFPIPGTKREKYLIEN 298 Pseudocohnilembus ...
OQS04340  232 ASLndlsek-dsrrrnPRFVPENFKNNKATTFFDLAAKKNV--TPAQLALAWVLHRg-----dDVVPIPGTKQPARIIEN 303 Thraustotheca clavata
PNW76476  226 RSAeqihea--dfrrkGFPRLDNLDKNLVLVDRLSAIAGRKgcSPGQLALAWVMARg-----pDVFPIPGTRSIANLEQN 298 Chlamydomonas rein...
OUS44823  213 VDPakfhesdlrgsifPRFTPENYARNLPLLDEARACAKEVdcSVAQLALAWTLAKg-----dNILPIPGTTNLAHLEEN 287 Ostreococcus tauri

Feature 1                     
3V0U_A    291 VGalkVKLTKEDLKEI 306 serpentwood
3V0T_A    290 VGalkVKLTKEDLKEI 305 serpentwood
Q09923    294 FGalkVKLSDATVKEI 309 fission yeast
EIE19339  294 VAavnVKLTAEEMKEL 309 Coccomyxa subellipsoidea C-169
EKX35269  293 AKavdIVLTAEDLQEL 308 Guillardia theta CCMP2712
CDF35760  310 VGsteIELSPEELEAL 325 carragheen
KRX04333  299 QNaaqIKLTPEVVKKI 314 Pseudocohnilembus persalinus
OQS04340  304 AGaadISLTPEELEEI 319 Thraustotheca clavata
PNW76476  299 MGalaVSLSPEECREL 314 Chlamydomonas reinhardtii
OUS44823  288 WQagsVQLSEDMVARL 303 Ostreococcus tauri

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