1KNA


Conserved Protein Domain Family
CD_HP1a_insect

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cd18653: CD_HP1a_insect 
Click on image for an interactive view with Cn3D
chromodomain of insect HP1a
CHRomatin Organization Modifier (chromo) domain of insect HP1a. HP1a is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. In Drosophila, there are at least five HP1 family proteins, this subgroup includes the CD of Drosophila melanogaster HP1a.
Statistics
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PSSM-Id: 349300
Aligned: 5 rows
Threshold Bit Score: 95.4838
Created: 26-Dec-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:1KNA; Drosophila melanogaster HP1 chromodomain binds a lysine 9-methylated histone H3 tail, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ####                  #  #       #   ####  #      
1KNA_A        16 EYAVEKIIDRRVRkGMVEYYLKWKGYpETENTWEPENNLDCQDLIQQYEA 65  fruit fly
P29227        23 EYAVEKILDRRVRkGKVEYYLKWKGYaETENTWEPEGNLDCQDLIQQYEL 72  Drosophila virilis
1170337       23 EYAVEKIIDRRVRkGKVEYYLKWKGYpETENTWEPENNLDCQDLIQQYEA 72  fruit fly
XP_011191481  23 EYAVEKICGRRVRkGKVEYFLKWKGYaEDENTWEPVENLDCQDLIQQYEA 72  Zeugodacus cucurbitae
XP_004521856  23 EYAVEKICGRRVRkGKVEYFLKWKGYpEEENTWEPVENLDCQDLIQQYEA 72  Ceratitis capitata

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