2K1B,5EJW,4MN3,2KVM,4X3K,2L12,2L1B


Conserved Protein Domain Family
CD_Cbx7

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cd18646: CD_Cbx7 
Click on image for an interactive view with Cn3D
chromodomain of chromobox homolog 7
CHRomatin Organization Modifier (chromo) domain of chromobox homolog 7 (CBX7), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells. CBX proteins may act as an oncogene or tumor suppressor in a cell-type-dependent manner, for example CBX8 promotes proliferation while suppressing metastasis, in colorectal carcinoma progression. CBX7 has been shown to function as a tumor suppressor in lung carcinoma and an oncogene in gastric cancer and lymphoma.
Statistics
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PSSM-Id: 349293
Aligned: 10 rows
Threshold Bit Score: 89.3776
Created: 5-Dec-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide binding
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:2L1B; human CBX7 chromodomain binds H3K27me3 peptide, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ####                # ## #   # ####  #### ##  #      
2K1B_A        18 GEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEE 73  human
5EJW_A        27 GEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEE 82  house mouse
4MN3_A         1 GEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEE 56  human
2KVM_A        10 GEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEE 65  house mouse
4X3K_A         5 GEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEE 60  house mouse
2L12_A         1 GEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEE 56  human
XP_004937799   7 GEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEDHILDPRLVVAYEEKEE 62  chicken
NP_001005071   7 GEQVFAVESIRKKRIRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVLAYEEKEE 62  tropical clawed frog
2L1B_A         1 GEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEE 56  human
XP_021335969   7 GEQVFAVESITKKRVRKGHVEYLLKWKGWPPKYSTWEPEEHILDPRLVLAYEEKEQ 62  zebrafish

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