Conserved Protein Domain Family
BTB_POZ_KCTD15

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cd18388: BTB_POZ_KCTD15 
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)
KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.
Statistics
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PSSM-Id: 349696
Aligned: 6 rows
Threshold Bit Score: 207.155
Created: 15-Sep-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative pentamer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the interface between subunits in Homo sapiens KCTD1 (5BXB) pentamer, defined at contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # # # # ## #####  #                   # #  # # # ### #  #   #  ## # # ### ##  # 
Q96SI1        55 NAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLL 134 human
Q6DCX3        29 NAPVHLDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKEINLL 108 African clawed ...
AFU55753      37 NAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLL 116 chicken
Q5XJ34        29 NAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSYLRTSKLLLPEDFKEFQLL 108 zebrafish
XP_007906101  36 NAPVHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLL 115 elephant shark
XP_006003217  36 NAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTCKLLLPDDFKDFNLL 115 coelacanth
Feature 1         #  #              
Q96SI1       135 YEEARYYQLQPMVRELERW 153 human
Q6DCX3       109 YEEAKYYQLLPMVKELERW 127 African clawed frog
AFU55753     117 YEEAKYYQLQPMIKELERW 135 chicken
Q5XJ34       109 YEEARYYQLTPMVKELERW 127 zebrafish
XP_007906101 116 YEEAKYYQLQPMLKELERW 134 elephant shark
XP_006003217 116 YEEAKYYQLQPMIKELERW 134 coelacanth

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