2DQA,3AB6


Conserved Protein Domain Family
lyz_i
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cd16890: lyz_i 
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I-type lysozyme
Invertebrate type (I-type) lysozyme, initially identified in starfish and marine bivalves, are found in various invertebrate phyla and are apparently ubiquitous in insects. Lysozymes cleave the beta-(1,4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan, the major bacterial cell wall polymer. I-type enzymes share structural similarity and the conserved glutamate catalytic residue of the lysozyme family.
Links
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Statistics
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PSSM-Id: 381611
Aligned: 44 rows
Threshold Bit Score: 102.038
Created: 1-Sep-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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sugar bindingcatalytichomodimer
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding site [chemical binding site]
Evidence:
  • Structure:2DQA: Tapes japonica lysozyme binds N-acetyl-D-glucosamine; contacts at 4A
  • Structure:3AB6: Meretrix lusoria lysozyme binds N-acetyl-D-glucosamine; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        ### ##  #                                   #
2DQA_A     10 KCLLCMCKLESggCKp--iGCRmd--vgSLSCGYFQIKqPYWIDCGkp-----------gkDWKSCSNDinCSSKCVQQY 74  Ruditapes philippi...
3AB6_A      9 RCLSCICKMESg-CRn--vGCKmd--mgSLSCGYFQIKeAYWIDCGrp-----------gsSWKSCAASsyCASLCVQNY 72  Meretrix lusoria
AMS37097   26 MCLNCMCKVATtsCTd--vGCNhd--reGIACGYYQIHyGYYIDCYkpvpdsgcrglseqeCWMKCSRDkpCAERCIQSY 101 Ruditapes philippi...
AFN66526   52 QCLQCICMAESn-CR----KIGymwyrgTLSCGYYMIDeIYWQECGrp-----------ggDFMHCALDysCARTCVKKY 115 Cristaria plicata
NP_501313  30 PCLLAMCDQDSg-CVp--lGCSvdq-fdRIGCGYFRLNiYQFQQCYqpgkkd---edteneAWMNCAQDyqCSASCIRTL 102 Caenorhabditis ele...
CEF60033   37 ECLKAMCKADSg-CQq--qGCSldi-hhRLGCGYFRMNiFQYKQCFqpgrki---gedvesAWIRCSEDyeCSSNCIMQV 109 Strongyloides ratti
ABC68610   21 NCLNCICQIEG--CEsqigKCRmd--vgSLSCGPFQIKePYWIDCGrp-----------ggDWKSCTTQmdCSRTCVRSY 85  Eisenia andrei
AGQ50334   21 SCLHAICVVESg-CQp--lGCKyd--vnGNACGYYQIHaGYYSDCGsp-----------gsSWQACAKDksCADSCVRAY 84  disc abalone
KOF93908   34 KCLQCLCDIETk-CKp--aDCYgg--dgPITCGYFQISkAFYDACGsp-----------gsSWQQCTKDkyCSTLCVQNY 97  Octopus bimaculoides
ABK34500   25 DCLKCICFVESt-CTipspLCHmd--vgSLSCGPYQIKlGYWQDARlkgg-------sldgDWQKCSATfdCSERAVQGY 94  Japanese sea cucumber

Feature 1        #                      #####                                
2DQA_A     75 MKRYathyRC------PLNCEGFAREHNGGPNGChs------srTLKYWellq-----kipGC 120 Ruditapes philippinarum
3AB6_A     73 MKRYakwaGC------PLRCEGFAREHNGGPRGCkk------gsTIGYWnrlq-----kisGC 118 Meretrix lusoria
AMS37097  102 MLRYrnknGA------GSDCENYVRLHAGGPYGAakwnqswynrTSYYWnya------rayGC 152 Ruditapes philippinarum
AFN66526  116 TTQLgehsGC------PDTCQTYARTHHGGPLGChn------keTIPFWhrv------qsfGC 160 Cristaria plicata
NP_501313 103 ATKFr--vKCy----gKSECETIARIHDGGANGCrd------rgTIGYWkrv-------rdSC 146 Caenorhabditis elegans
CEF60033  110 AARFr--lKCy----gKSPCELLSRTHDGGANGCrt------gaTISYWhhvk----eicpDC 156 Strongyloides ratti
ABC68610   86 MKRYg--tYCtg--grAPTCQDYARIHNGGPKGCqh------asTVGYWnkvkqccsskpgGC 138 Eisenia andrei
AGQ50334   85 LNRYg--tYCtg--grTPTCEDYARIHNGGPKGCvh------snTLGYWh-----------KV 126 disc abalone
KOF93908   98 MNKYi--nNCv-----QPNCLNFARLHFGGPSGCan------pnTLLFAlr--------vnKC 139 Octopus bimaculoides
ABK34500   95 MARY----ATyarlehNPTCEDFARIHNGGPNGFkn------paTEKYWlr--------vkKC 139 Japanese sea cucumber

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