2B49,4QUN,4RI5


Conserved Protein Domain Family
PTPc-N3
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cd14600: PTPc-N3 
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catalytic domain of tyrosine-protein phosphatase non-receptor type 3
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3), also called protein-tyrosine phosphatase H1 (PTP-H1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN3 interacts with mitogen-activated protein kinase p38gamma and serves as its specific phosphatase. PTPN3 and p38gamma cooperate to promote Ras-induced oncogenesis. PTPN3 is a large modular protein containing an N-terminal FERM domain, a PDZ domain and a C-terminal catalytic PTP domain. Its PDZ domain binds with the PDZ-binding motif of p38gamma and enables efficient tyrosine dephosphorylation.
Links
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Statistics
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PSSM-Id: 350448
Aligned: 8 rows
Threshold Bit Score: 562.164
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 10 residue positions
Conserved feature residue pattern:x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2B49_A         5 EGSMAQLKKGLEsGTVLIQFEQLYRKKPGlaitfaklpqNLDKNRYKDVLPYDttrvl-lqgnEDYINASYVNMeipaan 83   human
4QUN_A        28 EGSMAQLKKGLEsGTVLIQFEQLYRKKPGlaitfaklpqNLDKNRYKDVLPYDttrvl-lqgnEDYINASYVNMeipaan 106  human
4RI5_A        28 EGSMAQLKKGLEsGTVLIQFEQLYRKKPGlaitfaklpqNLDKNRYKDVLPYDttrvl-lqgnEDYINASYVNMeipaan 106  human
NP_001085662 638 QGSMEQLSKGLEtGVVLIQFEQLYRKKPGlaitcartgqNMDRNRYKDVLPYDatrvl-lngeDDYINASYVNMeipstn 716  African clawed...
EMC78638      26 DESMEQLRKGLEsGTVLIQFEQLYRKKPGlavtcakvpqNMDKNRYKDVLPYDatrii-lqgdEDYINANYVNMeipsvg 104  domestic pigeon
XP_687930    561 EESMARLEKGLVtGTLLLHFEKLYRKKEGmlmscakqseNMDKNRYKDVLPYDitrvvlqeegDDYINASHVKTepag-- 638  zebrafish
XP_014348410 651 EETMEQLKKGLDsGTVLIQFEQLYRKKPGmaitcaklseNMDKNRYKDVLPYDatrvv-lqenEDYVNASFVNMeipsad 729  coelacanth
XP_007895637 658 EESMIQLRKGLEsGAILNQFDQLYRKKPGmaitcaklpqNMDKNRYKDVLPYDvtrvv-ldgsEDYINANYVNMevsgts 736  elephant shark

Feature 1                                                                                        
2B49_A        84 lvnKYIATQGPlphTCAQFWQVVWDQklSLIVMLTTLTERGRTKCHQYWPdppdvmnhggFHIQCQSEDCTiaYVSREML 163  human
4QUN_A       107 lvnKYIATQGPlphTCAQFWQVVWDQklSLIVMLTTLTERGRTKCHQYWPdppdvmnhggFHIQCQSEDCTiaYVSREML 186  human
4RI5_A       107 lvnKYIATQGPlphTCAQFWQVVWDQklSLIVMLTTLTERGRTKCHQYWPdppdvmnhggFHIQCQSEDCTiaYVSREML 186  human
NP_001085662 717 ivnKYVATQGPlphTCAQFWQMVLEQklSIIIMLTTLTERGRTKCQQYWPdppevmeygkFRIICKTEDCTiaYVFREML 796  African clawed...
EMC78638     105 ivnRYIATQGPlphTCAHFWQVVWDHklSLIIMLTTLTERGRTKCHQYWPdppdvmeygsFRVRCHSEDCTiaYVVREMV 184  domestic pigeon
XP_687930    639 cvlQYIAAQGPlphTCTHFWRSVWEQdvNVIIMLTTLTERGRTKCHQYWPhppevrdygyLQVCCHSEECNlaYVTRQLT 718  zebrafish
XP_014348410 730 ivnKYIASQGPlphTCTLFWQTVWEQssSLIVMLTTLTERGRTKCHQYWPdppevkeygnFRVTCNSEDCNiaYVFREMI 809  coelacanth
XP_007895637 737 ilnRYIACQGPlphTCPYFWQTIWNQqsSLVVMLTTLTERGRVKCHQYWPdlqdvckygnFQVTCHTENYGiaYVFREMM 816  elephant shark

Feature 1                             ##                               #######                   
2B49_A       164 VTntqtgeeHTVTHLQYVAWPDHGVPDdSSDFLEFVNYVRSLRvd--sePVLVHCSAGIGRTGVLVTMETAMCLTErnlp 241  human
4QUN_A       187 VTntqtgeeHTVTHLQYVAWPDHGVPDdSSDFLEFVNYVRSLRvd--sePVLVHSSAGIGRTGVLVTMETAMCLTErnlp 264  human
4RI5_A       187 VTntqtgeeHTVTHLQYVAWPEHGVPDdSSDFLEFVNYVRSLRvd--sePVLVHCSAGIGRTGVLVTMETAMCLTErnlp 264  human
NP_001085662 797 LTdtetgdeFPIIHLQYVAWPDHGVPDdSSDFLEFATYVRQKRme--nqPVLVHCSAGIGRTGVLITMETAMCLIEhnqp 874  African clawed...
EMC78638     185 ITkveteqqHTVTHLQYVAWPDHGVPDdSMDFLEFVNCMRPKRve--nePVLVHCSAGIGRTGVLVTMETAMCLIErnqp 262  domestic pigeon
XP_687930    719 LTntqsgqqRSITHLQYVAWPDHGVPEdSSDFLDFVKSVRSMRqe--svPLMVHCSAGIGRTGVLITMETAMTLMEkekp 796  zebrafish
XP_014348410 810 LTniktgeeRAVTHLQYVAWPDHGVPDdPSNFLEFVTCVRQRRva--nePAIVHCSAGIGRTGVLVTMETAMCLTErnqp 887  coelacanth
XP_007895637 817 LTnletgeeRDVCHLQYVTWPDHGVPDdSTDFFDFVTRVRQKRikrenePVIVHCSAGIGRTGVLVAMETATCLIEnnqp 896  elephant shark

Feature 1                          #                  
2B49_A       242 IYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 278  human
4QUN_A       265 IYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 301  human
4RI5_A       265 IYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 301  human
NP_001085662 875 VYPLDVVRQMRDQRAMMVQTSSQYKFVCEAILRVYKD 911  African clawed frog
EMC78638     263 VYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYKE 299  domestic pigeon
XP_687930    797 VYPLEVITLMREQRAMLVQTSCQFTFVCEAILRVYRE 833  zebrafish
XP_014348410 888 VYPLDIVRTMRDQRPMMVQTSSQYRFVCEAILRVYDE 924  coelacanth
XP_007895637 897 VYPLDIVRTMRDQRAMMVQTSSQYKFVCEAILRVYEE 933  elephant shark

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