3C0G,3MFR,3C0H,3MFU


Conserved Protein Domain Family
STKc_CASK

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cd14094: STKc_CASK 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CASK belongs to the MAGUK (membrane-associated guanylate kinase) protein family, which functions as multiple domain adaptor proteins and is characterized by the presence of a core of three domains: PDZ, SH3, and guanylate kinase (GuK). The enzymatically inactive GuK domain in MAGUK proteins mediates protein-protein interactions and associates intramolecularly with the SH3 domain. In addition, CASK contains a catalytic kinase and two L27 domains. It is highly expressed in the nervous system and plays roles in synaptic protein targeting, neural development, and regulation of gene expression. Binding partners include parkin (a Parkinson's disease molecule), neurexin (adhesion molecule), syndecans, calcium channel proteins, CINAP (nucleosome assembly protein), transcription factor Tbr-1, and the cytoplasmic adaptor proteins Mint1, Veli/mLIN-7/MALS, SAP97, caskin, and CIP98. Deletion or mutations in the CASK gene have been implicated in X-linked mental retardation. The CASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270996
Aligned: 10 rows
Threshold Bit Score: 557.926
Created: 26-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3MFU: Human CASK kinase domain binds AMP-PNP-Mn2+; contacts at 4A.
  • Structure:3C0H: Human CASK kinase domain binds AMP-PNP; contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ###   # #            # #                                 #            
3C0G_A     22 FEDVYELCEVIGKGPFSVVRRCINRetGQQFAVKIVDVAKFTSspgLSTEDLKREASICHMLkHPHIVELLETYSSDgmL 101  human
3MFR_A     22 FEDVYELCEVIGKGAFSVVRRCINRetGQQFAVKIVDVAKFTSspgLSTEDLKREASICHMLkHPHIVELLETYSSDgmL 101  human
3C0H_A     22 FEDVYELCEVIGKGPFSVVRRCINRetGQQFAVKIVDVAKFTSspgLSTEDLKREASICHMLkHPHIVELLETYSSDgmL 101  human
3MFU_A     22 FEDVYELCEVIGKGAFSVVRRCINRetGQQFAVKIVDVAKFTSspgLSTEDLKREASICHMLkHPHIVELLETYSSDgmL 101  human
AAH77973    8 FEDVYELCEVIGKGPFSFVRRCINRetGQQFAVKIVDVAKFTSspgLSTEDLKREASICHMLkHPHIVELLETYSSDgmL 87   African clawed frog
Q24210      8 FDDVYELCEVIGKGPFSIVRRCIHResNQQFAVKIVDVAKFTAspgLSTADLKREATICHMLkHPHIVELLETYSSEgmL 87   fruit fly
1708832    13 LDEQLSIRDVIEQGPFSNVYRILHGpsNRKFLLRSINLNLFRQhtgLGFEEIDEEIRICQNLqHPYICRLEKTINSVhyR 92   Caenorhabditis el...
NP_694420   8 FEDVYELCEVIGKGPFSVVRRCINRetGQQFAVKIVDVAKFTSspgLSTEDLKREASICHMLkHPHIVELLETYSSDgmL 87   zebrafish
AAO83853   25 PCPCSEALHFCLGGPFSVVRRCLHRetRQQFAVKIVDVSKFTSspgLTVEDLKREATICHMLkHPHIVELLETYSSDmmL 104  great pond snail
XP_416769  12 LTRQEKVDEAFFRGPFSVVRRCINRetGQQFAVKIVDVAKFTSspgLSTEDLKREASICHMLkHPHIVELLETYSSDgmL 91   chicken
Feature 1        ####                                                  ## #             #     
3C0G_A    102 YMVFEFMDGADLCFEIVKRADagFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASkeNSAPVKLGGFGVAI 181  human
3MFR_A    102 YMVFEFMDGADLCFEIVKRADagFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPENVLLASkeNSAPVKLGDFGVAI 181  human
3C0H_A    102 YMVFEFMDGADLCFEIVKRADagFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASkeNSAPVKLGGFGVAI 181  human
3MFU_A    102 YMVFEFMDGADLCFEIVKRADagFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPENVLLASkeNSAPVKLGDFGVAI 181  human
AAH77973   88 YMVFEFMDGADLCFEIVKRADagFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASkeNSAPVKLGGFGVAI 167  African clawed frog
Q24210     88 YMVFEFMEGSDLCFEVVRRAVagFVYSEAVACHYMRQILEALRYCHENDILHRDVRPACALLATvdNSAPVKLGGFGSAI 167  fruit fly
1708832    93 HIIFENMEGNDICFEIVQRASngFVFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASkdTSAPLKLCGFGVAK 172  Caenorhabditis el...
NP_694420  88 YMVFEFMDGADLCFEIVKRADagFVYSEAVASHYMRQILEALRYCHDNNIVHRDVKPHCVLLASkeNSAPVKLGGFGVAI 167  zebrafish
AAO83853  105 YMVFEYMDGADLCFEIVKRASsgFVYSEAVASHYMRQVLEALRYCHTNNIIHRDLKPHCILLASteNSAPVKLGGFGVAT 184  great pond snail
XP_416769  92 YMVFEFMDGADLCFEIVKRADagFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASkeNSAPVKLGGFGVAI 171  chicken
Feature 1                                                                                     
3C0G_A    182 QLGES--GLVAGGRVGTPHFMAPEVVKRepYGKPVDVWGCGVILFILLSGCLPFYGtkERLFEGIIKGKYKMNPRQw-SH 258  human
3MFR_A    182 QLGES--GLVAGGRVGTPHFMAPEVVKRepYGKPVDVWGCGVILFILLSGCLPFYGtkERLFEGIIKGKYKMNPRQw-SH 258  human
3C0H_A    182 QLGES--GLVAGGRVGTPHFMAPEVVKRepYGKPVDVWGCGVILFILLSGCLPFYGtkERLFEGIIKGKYKMNPRQw-SH 258  human
3MFU_A    182 QLGES--GLVAGGRVGTPHFMAPEVVKRepYGKPVDVWGCGVILFILLSGCLPFYGtkERLFEGIIKGKYKMNPRQw-SH 258  human
AAH77973  168 QLGES--GLVAGGRVGTPHFMAPEVVKRepYGKPVDVWGCGVILFILLSGCLPFYGtkERLFEGIIKGKYKMNPRQw-NH 244  African clawed frog
Q24210    168 QLPGTreTIETHGRVGCPHYMAPEVVTRrlYGKGCDVWGAGVMLHVLLSGRLPFLGsgVRLQQSVARGRLSFEAPEw-KS 246  fruit fly
1708832   173 DLSEIg-GSMACGRVGVPQFMAPEIVRKdrVSCSSDIWSSGVVLFLLLAGRLPFSGstSDIYERIMQTDVDVDGYM--PN 249  Caenorhabditis el...
NP_694420 168 QLGES--GLVAGGRVGTPHFMAPEVVKRepYGKPVDVWGCGVILFILLSGCLPFYGtkERLFEAIIKGKYKVMNPRqwGH 245  zebrafish
AAO83853  185 QLPDG--QLITSGRVGTPQYMAPEVIERrpYGKPVDMWGCGVLLFILLGGYPPFCGtkERLYEIIVKGSYPMKPKQw-DQ 261  great pond snail
XP_416769 172 QLGES--GLVAGGRVGTPHFMAPEVVKRepYGKPVDVWGCGVILFILLSGCLPFYGtkERLFEGIIKGKYKMNPRQw-SH 248  chicken
Feature 1                                                                    
3C0G_A    259 ISESAKDLVRRMLMLDPAERITVYEALNHPWLkerdryayKIHLPETVEQLRKFNARRKLKGA 321  human
3MFR_A    259 ISESAKDLVRRMLMLDPAERITVYEALNHPWLkerdryayKIHLPETVEQLRKFNARRKLKGA 321  human
3C0H_A    259 ISESAKDLVRRMLMLDPAERITVYEALNHPWLkerdryayKIHLPETVEQLRKFNARRKLKGA 321  human
3MFU_A    259 ISESAKDLVRRMLMLDPAERITVYEALNHPWLkerdryayKIHLPETVEQLRKFNARRKLKGA 321  human
AAH77973  245 ISESAKDLVRRMLMLDPAERITVYEALNHPWLkerdryayKIHLPETVEQLRKFNSRRKLKGA 307  African clawed frog
Q24210    247 ISANAKDLVMKMLAANPHHRLSITEVLDHPWIrdrd-klqRTHLADTVEELKRYNARRKLKGA 308  fruit fly
1708832   250 ISESARNLVRRMLNADPSKRISAKEALNHEWIrdkehmasRKHMNDVIDQMRRYNESRKLKSN 312  Caenorhabditis elegans
NP_694420 246 ISESAKDLVRRMLMLDPAERITVYEALNHPWLkrdr-yayKIHLPETVEQLRKFNARRKLKGA 307  zebrafish
AAO83853  262 ISSQGKDLLFRLLEKDPEKRITVEQALEHTWIknkk-dvpRVHLHETVDELKKFNSRRKLKGA 323  great pond snail
XP_416769 249 ISESAKDLVRRMLMLDPAERITVYEALNHPWLkerdryayKIHLPETVEQLRKFNARRKLKGA 311  chicken

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