Conserved Protein Domain Family
SLC5sbd_DUR3
?
cd11476: SLC5sbd_DUR3 
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain
Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Links
?
Statistics
?
PSSM-Id: 271370
Aligned: 54 rows
Threshold Bit Score: 319.532
Created: 15-Jul-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Na binding site
Feature 1:Na binding site [ion binding site]
Evidence:
  • Comment:based on the structures of Vibrio parahaemolyticus vSGLT (SLC5), Aquifex aeolicus LeuT (SLC6), and the NCS1, Microbacterium liquefaciens Mhp1, bound with Na+, functional studies of Escherichia coli PutP (SLC5) and mammalian NIS (SLC5), and mutational analysis of vSGLT
  • Comment:one of two Na+ binding sites in Aquifex aeolicus LeuT, where it is referred to as the Na binding site 2
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                          #  #                       
P33413     14 YAIVLGLGAVFAGMMVLttyllKRYQK-EIITAEEFTTAGRsVKTGLVAAAVVSSWIWCSTLLTSSTKEYADGIfg-gYA 91  baker's yeast
YP_136370   2 VSSAIVLGLTAATVLVFtgiglFAARG-RIDSVETYISARDsAGSGTLAATVIASMMGVWILLSPAEAGAAFGGlpavLG 80  Haloarcula marismo...
YP_155915   8 TSTGITIIVLFGVFWVAf----GYWLGrKNRSHEDFALAGRnVGFAFAAATAMATWVTSNTTLVAPQLTYQFGIw--gMV 81  Idiomarina loihien...
YP_342822   9 LDPRLGWITLAILSMVWiw-lgWFWGR-NAKALDEYVLAGRrVGLALGTATAMATWVTSNTTMAAPQLAFQMGIw--gML 84  Nitrosococcus ocea...
ACV10872    4 TGVALGLTVLTLVAFSGlg--lLHSRG-RVGSVEDLITARDsVGEKRMTATLVASVMGVWILLSAPEAGASFGIaa-vVG 79  Halorhabdus utahen...
AEA81004    2 VLNIYTFILIFLCGAFAig--gFFFSK-KEKSVPAYLNASRsIRSPSLTASIVASCFGVWILIGPAEAATWGGIga-iTG 77  Candidatus Pelagib...
EFF75797    4 QTTALMWLLLFSGGFAVas--vLYTRR-KRGTLEDYIVARNsQGAFGTILTLMASTLGAWILFSPAQAATWGGLaa-vIG 79  Achromobacter piec...
EFV95692    7 TGPAIFWLVLFSALFAAag--iLYARR-WRESLEDFVVARNtQGPIATFATLLASALGAWILFSPPEAATWGGIpa-vIG 82  Lautropia mirabili...
EBA01402    4 TSTALVWLVLFAALFAIpg--lIYARH-KQDKLDDFLVARNsQSSSATLLTLLATTMGTWILFGPAQAATWGGIga-vTG 79  Marinobacter sp. E...
EHK61641    8 TGLWLSLCAVALAVPGL-----LYARR-HRDNLEDYIIARNsQNTRATVLTLVATTLGTWILFGPAQAATWGGIga-vLG 80  Halomonas sp. GFAJ-1

Feature 1                                                                                     
P33413     92 YAAGACFQIIAFAILAIKTKQMAPNAHTYlELVRTRYGKIGHGCYLFYAIATNILVTSMLLTSGSAVFSDLTGMNTIASC 171 baker's yeast
YP_136370  81 YAIGSAIPLLLFIPVGARIREVMPAGHSLtEFAYARFGSGMYLLVLLVSVFYMFIFLAAEMTGIAGALALVADVPLWQTS 160 Haloarcula marismo...
YP_155915  82 GYSFAALGLVLFAPMAKRIKELLPNGYTSgDFVRLRYGNLAWLVFIIISVVYAFGWLISLGMAGGILLESLSGLDYHIGM 161 Idiomarina loihien...
YP_342822  85 GYSLGAVGLLMFAPLAQRIRKLMPNGYTSgDFIRLRYGKVAWRIFLAISLCYGLGWLVSMGMAGGILINALTGIPYHYGM 164 Nitrosococcus ocea...
ACV10872   80 YAIGEALPMLAYAKIGPRVRAVIPDGHSLtEYAHARYGASMYAFVLAVSGLYMFVFLAAELTGISRALAMVADVPQWQTA 159 Halorhabdus utahen...
AEA81004   78 YALGQATPFLAMTVFGKRLRKIMPEGNSLtQFVYARYGSKMLKIVLVLSLFYVFIYLCAEVTAIAKIVNLIAGVELWKTS 157 Candidatus Pelagib...
EFF75797   80 YALGSMSPRLVMIPLGRRMRELIPHGHTLtEFLMARYGRPMYGLALFIMLFYLFIALSAEVTAIAKLVTMLAPVPLWATA 159 Achromobacter piec...
EFV95692   83 YALGSMSPLVAMLLLGRRMRQLMPHGHTLtEFLLTRYGRPMYALTLAIMVFYVFIELTAEITAISMLMTLLAPVPMGLTA 162 Lautropia mirabili...
EBA01402   80 YALGALAPRLIMIPLGKRIRTLMPEGHTLtEFVLGRYGRIMYGFVLVIMVFYLFISLTAGLTAIAKMVSLLAPVPLWLTA 159 Marinobacter sp. E...
EHK61641   81 YAFGSMVPRLVMIPLGRRMRELIPEGHGLtEFVIHRYGRTMYAFTLVIMLFYLFILLAAGLTAVARMVGLLAPIPLWVTA 160 Halomonas sp. GFAJ-1

Feature 1                                                                                     
P33413    172 FLLPVGVVVYTLFGGIKATFLTDYMHTCVIIIIVLVFAFKVYATsdvlGSPGKVYDLVREAAKRhpvdgnyqgeymtMTS 251 baker's yeast
YP_136370 161 LLIGGFVLVYTAYGGLLASIVTDTVQTLVILPLLAVGFGGALLSl---GGTSEFHATVVSADPTll----------dPGF 227 Haloarcula marismo...
YP_155915 162 TTILVICVGYTLFGGMRAVIATDFIQALIIIVGVSFIAYWIIDN----VGLESIHSNLTSEHPQll----------dMLF 227 Idiomarina loihien...
YP_342822 165 TVILTICVGYTLLGGFRAVIGTDFIQSLLILSGLVVIAWLAIDK----VGFDRIHASVAEERPQll----------nLLM 230 Nitrosococcus ocea...
ACV10872  160 VLVGGFVLLYTGYGGLRASIFTDTLQAIIVMPLLVIAAAGAVFAl---GGPGAVYDGIVATDPTll----------dPGF 226 Halorhabdus utahen...
AEA81004  158 LLILISTLIYTLRGGLKISIITDKLQFIIISIFLILIFYYLFISg--eVNISSELISLKAGNLId------------PKY 223 Candidatus Pelagib...
EFF75797  160 AIVMGTTLLYTTYGGLRSSIFTDQVQMMVILPLLVILCVVGWQAa---GGTLPTIQALQAKAPQll----------dLTD 226 Achromobacter piec...
EFV95692  163 TVVMGTVLLYTAVGGLRASIFTDKVQILIIVPMLLALVAIGWHVs---GGASGVTSRLAEKAPAll----------dFGD 229 Lautropia mirabili...
EBA01402  160 SIVMGATLLYTLYGGLRVTIFTDRVQMLVILPFLALLIGFGWQAt---GGLAPALQGLQEKAPHll----------nPLD 226 Marinobacter sp. E...
EHK61641  161 SVVMVATLIYTFYGGLRASIYTDKLQMVVIMPLLGLLLVFGWQAa---GGVAPTLAGLAESAPQll----------qVSD 227 Halomonas sp. GFAJ-1

Feature 1                                                                                     
P33413    252 KSAGILLIINLIGNFGTVFLDNGYWNKAISASpaasLKAYAIGGLAWFAVPSLISLTMGLACLAVetspnfptypdplts 331 baker's yeast
YP_136370 228 GPGLEFGLYVAFALLGANMLNQGVWQRVYAADgdgaLRRGMGIAAVVVVPMLLLSGLFGIAAAGLglte----------- 296 Haloarcula marismo...
YP_155915 228 PAAVMFLFNNIFFGLGEIFHSNVWWSRALSFKkn-vAYKAYLTGGLLWLPIPIVTGFIALAAPQLgifp----------- 295 Idiomarina loihien...
YP_342822 231 PAALMFLFNNLLFGVGEVFHSNVWWSRAFSFReg-iGFKAYFTAGILWMPIPVVAGFIALAVPALdlni----------- 298 Nitrosococcus ocea...
ACV10872  227 WPGLQFGLALSFAILGAELINQTWWQRIYAGSdsetVERGFLRASLANGLIVLVAAFFGVIAAGHanvvta--------s 298 Halorhabdus utahen...
AEA81004  224 FSGYTAGITFFIAVFATNLFDQGIWQRVYAAKsdqdLHKSFVSSFFIVLPVILILGFCGIVAVSLgqa------------ 291 Candidatus Pelagib...
EFF75797  227 PVGVKAGLTFFVAILLTGIFHQGNWQRIYAAKdarsMRNGFLLGGILAAPFIFLMGLFGLAFVGLapq------------ 294 Achromobacter piec...
EFV95692  230 AGGLKAGATFFVAILLTGIFHQGNWQRIYAARsiqdMQRGFLLGGLFVVPFILLMGLFGLAWVAMepg------------ 297 Lautropia mirabili...
EBA01402  227 INGLKSGLTFFLAVVLTGLFYQGTWQRVFAARdnkvIRNGFILSGLLSFPIIFIMGLFGLAFVGLglp------------ 294 Marinobacter sp. E...
EHK61641  228 IGGIRAGLTFFLAVALTGLFYQGTWQRIYAAKdtkvLRRGFWISGVCSFIVVALMGLFGLAFVGLgle------------ 295 Halomonas sp. GFAJ-1

Feature 1                                    #  ##                                            
P33413    332 fqansGLVLPAAAIAIMGkgGAVASLLMIFMAVTSAMSAELIAVSSVFTYDIYREYIDPras-gkkLIYTSHVACIFFGL 410 baker's yeast
YP_136370 297 -sgsaSIAFFLVVAEAFPtwVTLAVVVLAVLLVMSSADTMFNAIASVVTADLARLLDDPdqrtlwlGGRGLTVAVALAAM 375 Haloarcula marismo...
YP_155915 296 --pspDMIGPTVAAAVLGkaGAIIVFIVIFSALASSLDSLLAATSDLVTQDIFHKKLKPkas-dktLMRFNRSCILGLGV 372 Idiomarina loihien...
YP_342822 299 --paaDMVGPMVAGELLGvtGAVLVLVMVFSALSSSLDSLLAATSILVVEDLYRRHWRPhat-awqLRKATVIAIIGLGI 375 Nitrosococcus ocea...
ACV10872  299 egynaDLSFFLLLNESFPewLVLAVVLLALLLVMSSVDTLFNALSSLVTADLPRLIDDP-------DDRTLALGARAFTV 371 Halorhabdus utahen...
AEA81004  292 --kdpSIVIFSLLLKNGTvwLSISILVLALTLVISSMDTLINAISSLFIIESKKIIRSKs------SDFYLSISKIFLIL 363 Candidatus Pelagib...
EFF75797  295 --gdsSIALFSVIMPHAPawFVIALIPLGLSLVMSTADTAISAVSSIVAVDMRRLMPRAsg---rdMKRLARWAVLLLAI 369 Achromobacter piec...
EFV95692  298 --geaSVALFALVMPNLPawVALAFIPLGLALVMSSADTAISAITSIIAVDGARLLPQArp---arLLRLARILVLVLAI 372 Lautropia mirabili...
EBA01402  295 --gdgSVALFSVLLADVPvwFAIGLLPFGLALIMSSADSTISGLTSIMVIDLRRLLPKLgn---hsLLSLSRWLIVLLSI 369 Marinobacter sp. E...
EHK61641  296 --gdgSVALFSVLLADVPlwFALALVPLGLALVMSSADSTISATSSIIAVDMGRLLPNAss---asLMSMSRWLIVLAAI 370 Halomonas sp. GFAJ-1

Feature 1                                                                                     
P33413    411 Am-sGFSVGlyyggiSMGYIYEMMGIIISSAVLPVVLTLCSKdmnlvAAVVSPILGTGLAIMSWLvctkslykelt---- 485 baker's yeast
YP_136370 376 F---IGAQGy-----SVLQLFLTADLLAAGVFVPFLAGLYTErltgpGALVSGIAGLLVGFTYFPslrglmaaipg---- 443 Haloarcula marismo...
YP_155915 373 Vt-wLLCLPrv---aTLGALLNFAGAFVASTIWPIVLGLYHRrltgtYAACAMGFGTAFGMLSYF--------------- 433 Idiomarina loihien...
YP_342822 376 Lt-wLLCIPrl---aTLAELLYFTGAFVASTIWPIAAGLYWRrtnptGAVVAMGLGSMAGLIGYF--------------- 436 Nitrosococcus ocea...
ACV10872  372 Vi-aVAAIYvslrarSVIRLFFLADLLGAAVAFPLLYGLYSRrltgtGALLSSLAGLAFGLAYFPdlreyitaipiv--- 447 Halorhabdus utahen...
AEA81004  364 Is--CLVFMiasqgmSVLYMFLLADLLCCAAAIPVFYGMFKNdisgsNSMICVCAGLIAGLLLFPdlsfqksilvgglfn 441 Candidatus Pelagib...
EFF75797  370 PvmvVASQGy-----SVLYLFLLADLLCSAAAFPVFYGLFSRkhdglTATVSTVAGLAAGLFFFPapgdk---------- 434 Achromobacter piec...
EFV95692  373 PvvvVAAQGl-----SVLYLFLLADLLCAAAAFPVFLGLYSRrhdgvDALVATLAGLAAGLWMFPrpgqp---------- 437 Lautropia mirabili...
EBA01402  370 PvlfVAAQGy-----SVLYLFLLADLLCCAAAFPVFFGFYNAryqsyNAAISTFAGLATGLMLFPapgap---------- 434 Marinobacter sp. E...
EHK61641  371 PvtwVASQGy-----SVLYLFLLADLLCSAAAFPVFFGLFYRrytglNAVISTALGLVAGLAMFPapgas---------- 435 Halomonas sp. GFAJ-1

Feature 1                                        
P33413    486 ---vdttfmdypmLTGNLVALLSPAIFIPILTYVF 517 baker's yeast
YP_136370 444 ---vgsmlpapsfLIAFAGATLVSAALTAVATLLG 475 Haloarcula marismortui ATCC 43049
YP_155915 434 -------------VVGFYVAALVSCAVSGLICLVG 455 Idiomarina loihiensis L2TR
YP_342822 437 -------------AIGFYVAALIGAFVSMVIVLLS 458 Nitrosococcus oceani ATCC 19707
ACV10872  448 --gghlpapdglyLTSFAGAFILSTLLALVAAQLS 480 Halorhabdus utahensis DSM 12940
AEA81004  442 lqsfpiwisssllFWSFVSATLIPLFVIVVLRSKK 476 Candidatus Pelagibacter sp. IMCC9063
EFF75797  435 ---------ptflLESFLLAAFVPVLTTVLLRLAR 460 Achromobacter piechaudii ATCC 43553
EFV95692  438 ---------ldtlLESFLLAACVPIVVTGLMRLLR 463 Lautropia mirabilis ATCC 51599
EBA01402  435 ---------ltylLESFLLATFVPIAVSLLLLLLP 460 Marinobacter sp. ELB17
EHK61641  436 ---------tatlLESFLLAALVPVAVSLLLLRVL 461 Halomonas sp. GFAJ-1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap