5YLW,5YM3


Conserved Protein Domain Family
CYP76-like

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cd11073: CYP76-like 
Click on image for an interactive view with Cn3D
cytochrome P450 family 76 and similar cytochrome P450s
Characterized members of the plant cytochrome P450 family 76 (CYP76 or Cyp76) include: Catharanthus roseus CYP76B6, a multifunctional enzyme catalyzing two sequential oxidation steps leading to the formation of 8-oxogeraniol from geraniol; the Brassicaceae-specific CYP76C subfamily of enzymes that are involved in the metabolism of monoterpenols and phenylurea herbicides; and two P450s from Lamiaceae, CYP76AH and CYP76AK, that are involved in the oxidation of abietane diterpenes. CYP76AH produces ferruginol and 11-hydroxyferruginol, while CYP76AK catalyzes oxidations at the C20 position. Also included in this group is Berberis stolonifera Cyp80, also called berbamunine synthase or (S)-N-methylcoclaurine oxidase [C-O phenol-coupling], that catalyzes the phenol oxidation of N-methylcoclaurine to form the bisbenzylisoquinoline alkaloid berbamunine. The CYP76-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410696
Aligned: 55 rows
Threshold Bit Score: 550.212
Created: 17-Sep-2010
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:5YLW: Salvia miltiorrhiza CYP76AH1 binds heme; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                  ##       #   #       #
5YLW_A        56 SKRYGPLMSIHLGslYTVIVSSPEMAKEILHRHGQVFSGRTiAQAVHAcdhd---kisMGFLPVASEWRDMRKICKEQMF 132 Salvia miltiorr...
P47195        60 AQKYGPLIHLKFGlhSSIFASTKEAAMEVLQTNDKVLSGRQpLPCFRIkphi---dysILWSDSNSYWKKGRKILHTEIF 136 Berberis stolon...
O64899        56 AQTYGDIFTLKMGteTVVVASTSSAASEILKTHDRILSARYvFQSFRVkghv---ensIVWSDCTETWKNLRKVCRTELF 132 California poppy
EEF51432      64 AKVYGPLISLRLGnqVLVVASTPSSAAEVLKNHDRLLSARFiLKAIPSeshilervaiVWNPACNDHWKSLRALCRTELF 143 castor bean
ALG05140      69 SKTYGALFSIKLGmqPAIVISSPDMAKEFLRHKDATFSSRViTEAVKIgayd---attLVFVPYGARWRLLRKIMTMEVF 145 Sinopodophyllum...
ABR17519      64 ATKYGPLMSLSLGmkTTVVVSSPSMAKEVLKTHGHVFAGRIvTQAARSlshd---kssFLLCQYGSRWRTLRRISNTELF 140 Sitka spruce
XP_006878550  57 SLTYGPIMPFKLGmrKAVVISSPHPAKQIFKTHDRKFSSRPvPLAAKTlsyg---gnsLVWAAYGHHWRLLRRLSFTELF 133 Amborella trich...
O64900        57 AQTYGDIFTLKMGteTVVVASTSSAASEILKTHDRILSARYvFQSFRVkghv---ensIVWSDCTETWKNLRKVCRTELF 133 California poppy
Q9SP06        51 AETYGDLFSLKLGseTVVVASTPLAASEILKTHDRVLSGRYvFQSFRVkehv---ensIVWSECNETWKKLRKVCRTELF 127 opium poppy
A8CDR5        60 ARTHGPIMILWLGtqPTVMASTAEAAMEILKTHDRIFSARHiRMSFRLkhhi---kysLVWSDCTDYWKLLRKIVRTEIF 136 Japanese goldth...
Feature 1                                                       #                                
5YLW_A       133 snqsmeaSQGLRRQKLQQLLDHVQkcsdsgr-avdireAAFITTLNLMSATLFSsqate--fdskATMEFKEIIEGVATI 209 Salvia miltiorr...
P47195       137 sqkmlqaQEKNRERVAGNLVNFIMtkvgdv---velrsWLFGCALNVLGHVVFSkdvfe-ysdqsDEVGMDKLIHGMLMT 212 Berberis stolon...
O64899       133 tqkmiesQAHVREKKCEEMVEYLMkkqgee---vkiveVIFGTLVNIFGNLIFSqnifelgdpnsGSSEFKEYLWRMLEL 209 California poppy
EEF51432     144 spkaiesQAILREKKLAEMLEFLItkqgqa---vnvaeVVFGTIFNTISHLLFStdli---gfenQIGGVKSLLWSMMEM 217 castor bean
ALG05140     146 ssramelFQPARQQQVKDIINTLRsaagsqt-pvdiadAMFVVSTNIISNLICSkslfn--ntkkEGIKLKEMVGEALGT 222 Sinopodophyllum...
ABR17519     141 svkrldaLQDLRRVQVRGMIHQIFensvkgsgcvnighIAFHSAFNLIGNMAFGkdmfd--phfrASEDLKDAISKLMVL 218 Sitka spruce
XP_006878550 134 stkrlnsMEKFRKAEVSKTMASIYeesikgn-svnigsTVFSTMLGIVENMVCGnyvfk--kgdeLATELKGMVRDVLKL 210 Amborella trich...
O64900       134 tqkmiesQAHVREKKCEEMVEYLMkkqgee---vkiveVIFGTLVNIFGNLIFSqnifelgxpnsGSSEFKEYLWRMLEL 210 California poppy
Q9SP06       128 tqkmiesQAEVRESKAMEMVEYLKknvgne---vkiaeVVFGTLVNIFGNLIFSqnifklgdessGSVEMKEHLWRMLEL 204 opium poppy
A8CDR5       137 spkmlqaQSHVREQKVAELIDFLRskegqv---vkisqFVFGTLLNILGNVVFSkdvfv-ygdetDKGGIQNLIREMLMI 212 Japanese goldth...
Feature 1                                                                                        
5YLW_A       210 VGVPNFADYFPILRPFDPQGvkrrADVFFGKLLAKIEGYLNERLESKRAnpnapkkddflei---------vvdiiqane 280 Salvia miltiorr...
P47195       213 GGDFDVASYFPVLARFDLHGlkrkMDEQFKLLIKIWEGEVLARRANRNPepkdmld--------------------vlia 272 Berberis stolon...
O64899       210 GNSTNPADYFPMLGKFDLFGqrkeVAECLKGIYAIWGAMLQERKLAKKVdgykskndf----------------vdvcld 273 California poppy
EEF51432     218 ATSPNIAEFYPILAPLDPQGlkrkMTKCLKEMFGVWEIYIKERRRTHDHdhaapktdf----------------ldifls 281 castor bean
ALG05140     223 VGQPNVADVIPFLKPFDPQGlqrrVTKVAKRFDDFFEKLIDERLKERTKglkanengrldlldv-----fldyksdkkde 297 Sinopodophyllum...
ABR17519     219 HTAPNLADYFPCLQFLDLQGvyrnTGIYRKKAYDVMDKFIEDRLAKRGKnsdrtddgkkdl----------ldvlldmrs 288 Sitka spruce
XP_006878550 211 SGEPNASDFFPFLRGLDLQGverrAQKLRERFDGIFSEMIERRLKDMREkgmvnerdeesgrgikesdflgvllelmdhn 290 Amborella trich...
O64900       211 GNSTNPADYFPMLGKFDLFGqrkeVAECLKGIYAIWGAMLQERKLAKKVdgyqskndf----------------vdvcld 274 California poppy
Q9SP06       205 GNSTNPADYFPFLGKFDLFGqskdVADCLQGIYSVWGAMLKERKIAKQHnnskkndfv-----------------eilld 267 opium poppy
A8CDR5       213 GAEPNVAEFYPSLEELDLQGlkkkCDERFIRVMKMWEGTVKERKANRNEeskdmld--------------------vlla 272 Japanese goldth...
Feature 1                      #  ##  ##                                                         
5YLW_A       281 fklKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNpdKMARLKAELKSVAGdekivdesAMPKLPYLQAVIKEVMRIH 360 Salvia miltiorr...
P47195       273 ndfNEHQINAMFMETFGPGSDTNSNIIEWALAQLIKNpdKLAKLREELDRVVGrsstvkesHFSELPYLQACVKETMRLY 352 Berberis stolon...
O64899       274 sglNDYQINALLMELFGAGTETSASTIEWAMTELTKNpkITAKIRSEIQTVVGersv-kesDFPNLPYLEATVKETLRLH 352 California poppy
EEF51432     282 ngfDDDQINWLVMELLSAGTDTTSTSVEWAMAELLKNkeAMKKVREELDREINknpi-kesHVSQLPYLNACVKETLRLH 360 castor bean
ALG05140     298 esfTRVDIKGMLMDMFTAGADTTSSTVEWGMTEILRNprVYKKVLEELDQVVGrdryveetDIAKLPYFQAVTKEVFRLH 377 Sinopodophyllum...
ABR17519     289 defTLTDIRGYLNDMFVAGSDTTAVTIEWAIAELVRNpeKLKRAQAELEEVIGlnrrleesDTERLPYLRAVVKEVFRLH 368 Sitka spruce
XP_006878550 291 eglQMEHVKGMLMDMFIAGTDTTSATVEWAMAELLNHpyVMEEARDELRRVIGkdkmmeesHIPDVPFLQAIVKEVLRLH 370 Amborella trich...
O64900       275 sglNDYQINALLMELFGAGTETSASTIEWAMTELTKNpkITAKLRSELQTVVGersv-kesDFPNLPYLEATVKETLRLH 353 California poppy
Q9SP06       268 sglDDQQINALLMEIFGAGTETSASTIEWALSELTKNpqVTANMRLELLSVVGkrpv-kesDIPNMPYLQAFVKETLRLH 346 opium poppy
A8CDR5       273 ndfNDAQINALFLETFGPGSETSSATIEWVIAELIKSpkEMAKVRKELNEVVGtsti-kesDLPQLPYLQACIKEAMRLH 351 Japanese goldth...
Feature 1         #   ## #                                                               ####  ##
5YLW_A       361 PPgpLLLPRKAESDQEVnGYLIPKGTQILINAYAIGRDpsiWTDPETFDPERFLdnkid----fkgqDYELLPFGSGRRV 436 Salvia miltiorr...
P47195       353 PPisIMIPHRCMETCQVmGYTIPKGMDVHVNAHAIGRDpkdWKDPLKFQPERFLdsdie----yngkQFQFIPFGSGRRI 428 Berberis stolon...
O64899       353 PPtpLLLPRRALETCTIlNYTIPKDCQIMVNAWGIGRDpktWTDPLTFSPERFLnssvd----frgnDFSLIPFGAGRRI 428 California poppy
EEF51432     361 PPapFLIPRRATENCEVmNYTIPKDSQVLVNVWAIGRDpsvWEDPSSFKPERFLgssld----vkghDFELIPFGSGRRI 436 castor bean
ALG05140     378 PAvpFLIPRRADEDCEVcGYHVPKHAMVFVNVWGISRDpnvWSDPCEFKPERFLgsdvd----vkglDFELLPFGTGRRS 453 Sinopodophyllum...
ABR17519     369 PAgpLLVPHRADGRFEIaGFVIPKHSRVLVNVWGMGRDpqiWNEPLKFVPERFIddemcgqmdykgkDFELIPFGAGTRM 448 Sitka spruce
XP_006878550 371 PAapLLIPRLCDSDCQIdGHIIEKNTEVLVNVWAIGRDpkvWSDPLKFDPSRFVgtnle----fkgnDYELLPFGAGRRI 446 Amborella trich...
O64900       354 PPtpLLLPRRALETCTIlNYTIPKDCQIMVNAWGIGRDpktWIDPLTFSPERFLnssvd----frgnDFSLIPFGAGRRI 429 California poppy
Q9SP06       347 PAtpLLLPRRALETCKVlNYTIPKECQIMVNAWGIGRDpkrWTDPLKFSPERFLnssid----fkgnDFELIPFGAGRRI 422 opium poppy
A8CDR5       352 PAapFLLPRRAAETCEVmGYTIPKNSQVLVNAYAIGRDpksWKDPSTFWPERFLesdvd----fhgaHYQFIPFGSGRRT 427 Japanese goldth...
Feature 1        ###  ##                                                
5YLW_A       437 CPGMPLATRILHMATATLVHNFDWkleddsTAAADHAGELFGvAVRRAVPLRIIP 491 Salvia miltiorrhiza
P47195       429 CPGRPLAVRIIPLVLASLVHAFGWelpdgvPNEKLDMEELFTlSLCMAKPLRVIP 483 Berberis stolonifera
O64899       429 CPGLPIANQFIALLVATFVQNLDWclpngmSVDHLIVEEKFGlTLQKEPPLFIVP 483 California poppy
EEF51432     437 CPGLPMATRQLSLVLASLIHCFDWslpnggDPAKVDMTEKFGiTLQMEHPLLIIP 491 castor bean
ALG05140     454 CAGMPLGNRMVQYSLASVIHAFEWef---pLDIVQDVSEKAGvTLQKAKTLVGIP 505 Sinopodophyllum hexandrum
ABR17519     449 CVGLPLASRMVHLVLGSLIHSFEWappkgmSAEQMDMTEKFGlALQKAVPLEAIA 503 Sitka spruce
XP_006878550 447 CIGMPLASSMVHLVLGSLLHYFNWk-----VEGEVDMTEEFGiTLQKALPLVVVA 496 Amborella trichopoda
O64900       430 CPGLPIANQFIALLVATFVQNLDWclpngmSVDHLIVEEKFGlTLQKEPPLFIVP 484 California poppy
Q9SP06       423 CPGVPLATQFISLIVSSLVQNFDWgfpkgmDPSQLIMEEKFGlTLQKEPPLYIVP 477 opium poppy
A8CDR5       428 CVGMPLATRTIPLIVGSLVHNYDFglpggnRPEDLKMNEMLSlTLAIDPSLCVVP 482 Japanese goldthread

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