5HT6


Conserved Protein Domain Family
SET_SETD5-like

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cd10529: SET_SETD5-like 
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins
SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.
Statistics
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PSSM-Id: 380927
Aligned: 34 rows
Threshold Bit Score: 96.9601
Created: 28-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activeputative SAM
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 binds H3K36M peptide and SAM.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        ##                        #         #                         
5HT6_A       5 NLLFKPPVeshi---qknKKILKSAKd--------LPPDALIIEYrGKFMLREQFEANGyff------------------ 55   human
KII64767    43 QTFTLKTGqkvf---lgiIQILKCAKl--------ISDDKFVCEMkGELHIFNDCSYIQsny------------------ 93   Thelohanellus ki...
PIK52995   318 TKVCIGQVsk------geVNGVVTLEq--------IPANQPIMQLsGTLSLKDNKRKNHsk------------------- 364  Japanese sea cuc...
EDQ89227  2738 PALTSLEIak-------nRPAIFVNQa--------VAKDMPLLEFcGNVVTTDSLELEApvt------------------ 2784 Monosiga brevico...
KNC77845   323 ANVCERPVek------sfQRGLFLSTqcs----rvWSAGEDIHEYsGQLCASSAFVREWekeeaf--------------- 377  Sphaeroforma arc...
Q10362     215 VPISSSKFcc-------sRFGLVSTCe--------IPPNTPIMEVkGRVCTQNEYKSDPknqyn---------------- 263  Schizosaccharomy...
O44757     638 NKLCVSNGp--------rSKRVLKTKi-------aRRAGEFLCEYaGEVITREQAQEKFaq------------------- 683  Caenorhabditis e...
OUM68075   149 ERISIYDGef-------nHYGLFAAAd--------IPKNTYLCDIkGTIKYKSNISSIYsfyhndndeinnntsninynm 213  Piromyces sp. E2
KND04178   255 IPVAVWDPlppnpvsgvrRFALFATVd--------IPANTYVTDIkGALSGKENLEKAKgldlle--------------- 311  Spizellomyces pu...
KGG51222   566 RSLRLFTRefkapntgtkSIGVFLTEddaaegsrpLLPGSFITMLtGTLLTRSALAEEFgsskdd--------------- 630  Microsporidia sp...
Feature 1                                       ########                        #####          
5HT6_A      56 -------------------------------krPYPFVLFYSkfh----glEMCVDARTfg-nEARFIRRSCt------- 92   human
KII64767    94 -------------------------------naYSSFIYNFNlf-----gqTLTLDARTst-hISRYIRRSCq------- 129  Thelohanellus ki...
PIK52995   365 --------------------------------qLESFMFVYSsfc----ntEMILNAGShd-nIARFTRKSCc------- 400  Japanese sea cuc...
EDQ89227  2785 -------------------------------eaPQPFIWFAKs-------mPVCIDARVlg-nESRFLRRSCh------- 2818 Monosiga brevico...
KNC77845   378 ----------------------------ditkrMCPHVVFLKg--------GVCVNARYya-nLTRCVRRSCr------- 413  Sphaeroforma arc...
Q10362     264 -----------------------------ilgaPKPHVFFDSn-------sQLVVDSRVag-sKARFARKGCq------- 299  Schizosaccharomy...
O44757     684 --------------------------------dRDPRIIAIAa--------HLFVDATKrs-nIARFIKHSCk------- 715  Caenorhabditis e...
OUM68075   214 semvdqhenvainnlnsnnindsnktnkkssfiMDPFIFVHPaqe----lnSLIVDSREyg-nEGRFIRFYCegnd-ipl 287  Piromyces sp. E2
KND04178   312 ---------------------------vdncvlAPPFVFAHPahalrmgdqPLAVDAREwgerGGRYVRYWCggddamss 364  Spizellomyces pu...
KGG51222   631 ---------------------------kaasriLQYFLFFHPt-------lPLVVDARKag-nMARFIRRSCr------- 668  Microsporidia sp...
Feature 1           #                                            #           #######
5HT6_A      93 -PNAEVRHEIq-----------------------------dGTIHLYIYSIHSIPk-GTEITIAFDFDY 130  human
KII64767   130 -PNCRILCSNfd---------------------------eaSKVRVFLCSNQSINn-LEEITIGVDRNE 169  Thelohanellus kitauei
PIK52995   401 -PNAEIRHMIf-----------------------------dGEIHLYLFALKDIGs-NSEVTLGLDFDV 438  Japanese sea cucumber
EDQ89227  2819 -PSAAVKLCRs-----------------------------gSRHCFVVTALRALGk-GTEITIAFDVDP 2856 Monosiga brevicollis MX1
KNC77845   414 -ANAEVVVCRveddahkavv------------gdlirpesvTERHRISITLKDTRa-SGELTVVHVGAR 468  Sphaeroforma arctica JP610
Q10362     300 -SNSVVSSVYmng--------------------------snSVPRFILYSTTHIAp-ETEIIGDWTLDI 340  Schizosaccharomyces pombe 9...
O44757     716 -PNSRLEVWSv-----------------------------nGFYRAGVFALSDLNp-NAEITVDKSDLL 753  Caenorhabditis elegans
OUM68075   288 tPNAKLQSIIcpeynekntn-----------snnhvekekkYKLILAIISSHDIKk-GEEIILSTSVTN 344  Piromyces sp. E2
KND04178   365 kCNAHLRSVTvyeenddetdep--------lvedgsgltlnEKIMLAIFTTKRVGp-AEEIVLGKGATG 424  Spizellomyces punctatus DAO...
KGG51222   669 -PNVAMRGIFvtggshvshykedpekaqenineadpdslaiATFSIGIFSVDRIRpgIDELMLPLDSNG 736  Microsporidia sp. UGP3

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