2OLM,2D9L


Conserved Protein Domain Family
ArfGap_AGFG1

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cd08857: ArfGap_AGFG1 
Click on image for an interactive view with Cn3D
ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)
The ArfGAP domain and FG repeat-containing proteins (AFGF) subfamily of Arf GTPase-activating proteins consists of the two structurally-related members: AGFG1 and AGFG2. AGFG1 (alias: HIV-1 Rev binding protein, HRB; Rev interacting protein, RIP; Rev/Rex activating domain-binding protein, RAB) and AGFG2 are involved in the maintenance and spread of immunodeficiency virus type 1 (HIV-1) infection. The ArfGAP domain of AGFG1 is related to nucleoporins, which is a class of proteins that mediate nucleocytoplasmic transport. AGFG1 plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs, possibly together by the nuclear export receptor CRM1. In humans, the presence of the FG repeat motifs (11 in AGFG1 and 7 in AGFG2) are thought to be required for these proteins to act as HIV-1 Rev cofactors. Hence, AGFG1 promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm, which is an essential step for HIV-1 replication.
Statistics
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PSSM-Id: 350082
Aligned: 6 rows
Threshold Bit Score: 253.808
Created: 12-Feb-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitearginine finger
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2OLM; human GAP domain of AGFG1 binds Zn(2+) ion
  • Comment:the coordination of the Zn2+ ion by 4 cysteines would indicate that this ion plays a structure stabilization role rather than catalytical role.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #  #                #  #                                        
2OLM_A        12 HLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNppHRVKSISMTTFTQQEIEFLQKHGNEVCKQI 91  human
AAH56768      13 HLKMLREMTSLAPNRKCFDCDQRGPTYANMTVGSFVCTSCSGILRGLNppHRVKSISMTTFTQQEIELLQKHGNEVCKQI 92  zebrafish
NP_001084973  13 HLKMLREMTSLPHNRKCFDCDQRGPTYANMTTGAFVCTSCSGILRGLNppHRVKSISMTTFTQQEIEFLQKHGNDVCKQI 92  African clawed ...
XP_002198433  13 HLKLLREMSSLPPNRKCFDCDQRGPTYTDMTVGSFVCTSCSGILRGLNppHRVKSISMTTFTQQEIEFLQKHGNEVCKQI 92  Taeniopygia gut...
2D9L_A         7 GLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNppHRVKSISMTTFTQQEIEFLQKHGNEVCKQI 86  human
NP_001016202  13 HLKMLREMTSLPHNRKCFDCDQRGPTYANMTTGAFVCTSCSGILRGLNppHRVKSISMTTFTQQEIEFLQKHGNDVCKQI 92  tropical clawed...
Feature 1                                            
2OLM_A        92 WLGLFDDrssaipdfrdpqkvkeFLQEKYEKKRWYV 127 human
AAH56768      93 WLGLYDDrnlaipdfrepqkvkeFLQDKYEKKRWYV 128 zebrafish
NP_001084973  93 WLGLFDDrssaipdfrdpqkvkeFLQEKYEKKRWYV 128 African clawed frog
XP_002198433  93 WLGLFDDrssaipdfrdpqkvkeFLQEKYEKKRWYV 128 Taeniopygia guttata
2D9L_A        87 WLGLFDDrssaipdfrdpqkvkeFLQEKYEKKRWYV 122 human
NP_001016202  93 WLGLFDDrssaipdfrdpqkvkeFLQEKYEKKRWYV 128 tropical clawed frog

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