1YHF,2Q30,3FJS,3RNS,5J4G,5J4F


Conserved Protein Domain Family
cupin_HP0902-like

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cd02230: cupin_HP0902-like 
Helicobacter pylori HP0902 and related proteins, cupin domain
This family includes prokaryotic and archaeal proteins homologous to HP0902, a functionally uncharacterized protein from Helicobacter pylori and Spy1581, a protein of unknown function from Streptococcus pyogenes. These proteins demonstrate all-beta cupin folds that cannot bind metal ions due to the absence of a metal-binding histidine that is conserved in many metallo-cupins. HP0902 is able to bind bacterial endotoxin lipopolysaccharides (LPS) through its surface-exposed loops, where metal-binding sites are usually found in other metallo-cupins, and thus may have a putative role in H. pylori pathogenicity.
Statistics
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PSSM-Id: 380358
Aligned: 104 rows
Threshold Bit Score: 71.3868
Created: 3-Feb-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
homodimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:5J4F: Helicobacter pylori uncharacterized protein HP0902 forms a homodimer; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  # #                     # # #            #    #####                   
1YHF_A        30 LSRTLVQrqdLGITVFSLDKg-QEIGRHSSPGDAXVTILsGLAEITIDqETYRVAeGQTIVXPaGIPHALYAve----aF 104 Streptococcus p...
5J4G_A        16 HIEVLNEnssHKEIRICMPKg-AVMDKHKAPGAISVQVLeGKIVFEVGdEKIEMPkGALISLEaQVLHRLDAle----nS 90  Helicobacter py...
5J4F_A        36 HIEVLNEnssHKEIRICMPKg-AVMDKHKAPGAISVQVLeGKIVFEVGdEKIEMPkGALISLEaQVLHRLDAle----nS 110 Helicobacter py...
NP_213642     16 VSELVYEdenAKVIRFYLKKg-QEIKPHTSPSSVYITVLkGKVTFTAGeEKIKGEqGSTIYYEpNELHGFVAe-----eD 89  Aquifex aeolicu...
NP_207695     16 HIEVLNEnssHKEIRICMPKg-AVMDKHKAPGAISVQVLeGKIVFEVGdEKIEMPkGALISLEaQVLHRLDAle----nS 90  Helicobacter py...
BAC18768      66 ATRRILKaegVDLISFTFSPg-QVLGEHHTAHPVTIQCLdGEIDLVLAdTTVRLRqGTLLHLEaGITHHVQAtpeatepA 144 Corynebacterium...
BAC18769      21 AVKRLLQgdgANLIVFTFSPg-HCLPDHRAAHPITVCSLkGEILFSCGdETVTLSpGSVVHLReHITHRVDYpadaegeA 99  Corynebacterium...
YP_001035227  12 FAETPVQe-eGRIIHHLHLAkgKEVPEHSADALVTVVCLsGDVSFSAGeQTVRLVaGSFLTMEpNEPHSLVGe-----eD 85  Streptococcus s...
WP_102213811 317 AVRRLQTadgVNLISMRFRAg-QALPDHRAAHPITVQCLqGQVRFSVGdRTETLTpGRVAHLPaMVPHRVDAde----dS 391 Corynebacterium...
WP_068133051  25 KTSTLLQtdhMKVLRLVLPAg-KKIAEHQAPSDITVQCLeGRIQFTSGgNPQELVaGDLLFLTaAAPHALEAle----dS 99  Planctomyces sp...
Feature 1          #     
1YHF_A       105 QXLLVVVK 112 Streptococcus pyogenes M1 GAS
5J4G_A        91 VIRLSLSK 98  Helicobacter pylori 26695
5J4F_A       111 VIRLSLSK 118 Helicobacter pylori 26695
NP_213642     90 SVLEAVIT 97  Aquifex aeolicus VF5
NP_207695     91 VIRLSLSK 98  Helicobacter pylori 26695
BAC18768     145 TILVSLLT 152 Corynebacterium efficiens YS-314
BAC18769     100 VMLLTMLT 107 Corynebacterium efficiens YS-314
YP_001035227  86 SHLLVIKQ 93  Streptococcus sanguinis SK36
WP_102213811 392 VFLLSMLT 399 Corynebacterium xerosis
WP_068133051 100 SVLVTILL 107 Planctomyces sp. UC8

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