1KAQ,2H2A,1YUL,3DV2,1K4K,3H05


Conserved Protein Domain Family
NMNAT

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cd02165: NMNAT 
Click on image for an interactive view with Cn3D
Nicotinamide/nicotinate mononucleotide adenylyltransferase
Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis.
Statistics
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PSSM-Id: 185680
Aligned: 91 rows
Threshold Bit Score: 103.091
Created: 31-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site(T/H)XGH motif
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2H2A, Staphylococcus aureus nicotinic acid mononucleotide adenylyltransferase with bound nicotinic acid adenine dinucleotide, contacts 4A
  • Comment:NMNAT is a dual substrate enzyme. It can use both NMN and NaMN as substrate

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #####   # ##  #                       #                                      
1KAQ_F      9 IGIFGGTFDPPHNGHLLMANEVLYqag---ldEIWFMPNQIPphkqnedytDSFHRVEMLKLAiq----sNPSFKLELve 81  Bacillus subtilis
2H2A_A      4 IVLYGGQFNPIHTAHMIVASEVFHelq---pdEFYFLPSFMSplkkhhdfiDVQHRLTMIQMIid----eLGFGDIXDde 76  Staphylococcus aureus
NP_895287   8 IALFGTSADPPTCGHQALLEGLVAmf-----pKVATWASDNPmkr---hcaPLEKRKALLATLvka--iaNPQLELMQel 77  Prochlorococcus ma...
NP_893562   9 IALFGTSADPPTIGHKKILEELSNiy-----sCVIAYASDNPkkk---hkeNIFFRNLLLKSLikd--inNPKIIFNQki 78  Prochlorococcus ma...
NP_681968   3 IALFGTSADPPTAAHGDILQWLSDry-----dRVFVWAADNPfkg---qqtPLPYRQAMVNLLvrs--lnRPNVEHHPel 72  Thermosynechococcu...
EAL20763   92 LAILDSSFNPPTFAHQAIISSSYPvkakpytaRLLLYTPKNAaktptasdaTPLQRLEMMSLLss----sLRSLQASKtq 167 Cryptococcus neofo...
NP_486523   4 IALFGTSADPPTAGHQIILRWLSEry-----dWVAVWAADNPfks---hqtLLEHRAAMLRLLiadieapRQNIALEQdl 75  Nostoc sp. PCC 7120
NP_875989   9 IALLGTSADPPTIGHKILLTELSKif-----pKVVTWASDNPsks---hktSLNQRYELLNTLvea--iaLPNLELKQel 78  Prochlorococcus ma...
YP_292169   8 IALFGTSADPPTLGHEALLSELTKif-----pKVITWASDNPdkn---hqiPLLKRTQLLRILvkk--isHPKLELVQel 77  Prochlorococcus ma...
NP_896598   4 IALLGTSADPPTCGHQALLKGLLSly-----pQVATWASDNPqkh---hgaPLALRAQLLQALvee--inDPRLQQEQtl 73  Synechococcus sp. ...
Feature 1                           ###                  # ## ##        ##                    
1KAQ_F     82 me----------------regpSYTFDTVSLLKQRypn-dqLFFIIGADMIEy--lPKWYkl------------dELLNL 130 Bacillus subtilis
2H2A_A     77 ik----------------rggqSYTYDTIKAFKEQhkd-seLYFVIGTDQYNq--lEKWYqi------------eYLKEM 125 Staphylococcus aureus
NP_895287  78 --------------------ssPWAITTLKRANTRwps-neLVFVVGSDLAGq--iPHWKda------------rAVLQL 122 Prochlorococcus ma...
NP_893562  79 --------------------ssQWAIESIEECQKNyps-skVDFVIGSDLITe--iFSWKnf------------dKIIHA 123 Prochlorococcus ma...
NP_681968  73 --------------------shPYTLYSVEQVKQRwpg-elFTLVVGSDVLRk--lPQWYqa------------eKLLGQ 117 Thermosynechococcu...
EAL20763  168 qesiatalihaptfvakasilrSYLVNELNLGQRGee--aeLSFLVGMDTLLrifdPKYYpegemrtklegfflpPPRGA 245 Cryptococcus neofo...
NP_486523  76 --------------------ssFRTLETLEKAKLRwganteFTLIIGSDLLSq--lPRWYrv------------eELLQQ 121 Nostoc sp. PCC 7120
NP_875989  79 --------------------ssKWAIKTLERAAKHwpn-kgLILIIGSDLVTd--iPHWFea------------kNVLQH 123 Prochlorococcus ma...
YP_292169  78 --------------------ssPRTIHTLKKAFQLwpe-asFSFVIGSDLAMh--vPKWLna------------kSILSK 122 Prochlorococcus ma...
NP_896598  74 --------------------shPFTIRTIEQATARwpe-aeLVFVVGSDLAAl--iPGWKss------------aQWLSR 118 Synechococcus sp. ...
Feature 1           ##                                         #                              
1KAQ_F    131 IQFIGVKRpgfhvetpyp---------------------llfadvpefeVSSTMIRERfksk--kptdYLIPDKVKKYVE 187 Bacillus subtilis
2H2A_A    126 VTFVVVNRdknsqnvena---------------------miaiqiprvdISSTMIRQRvseg--ksiqVLVPKSVENYIK 182 Staphylococcus aureus
NP_895287 123 ARLAIAPRqgwplqlqqlealec------------lggriellpmqipaTSSSEVRSQpk-------pAQIPAALWPLVL 183 Prochlorococcus ma...
NP_893562 124 VKLLIIKRegypiesktlkmlki------------nkvifeisslnipnISSSMVRLNnn-------ySDLPESLIDIVK 184 Prochlorococcus ma...
NP_681968 118 VQLLVLQRpgvvidpqdwqvvqr------------lcphvelanyrgpaVSSTTYRQQrd-------aQQLPPAIAQYIQ 178 Thermosynechococcu...
EAL20763  246 GANLVSARrgttladrefeenllkrddvkpwvengkvrvlgdgrdgwenVSSTLVRERvrksdwesvnKLLGEGMSMYIQ 325 Cryptococcus neofo...
NP_486523 122 VQLLIVPRpgyaidgtsleavqq------------lggkiaiasftgldVSSTAYRERge-------tEALTPPIVEYIH 182 Nostoc sp. PCC 7120
NP_875989 124 AQLGIVPRegwpignsnlekike------------mggtpillplkipeTASSTIHNHll-------fSQIPKALLPILK 184 Prochlorococcus ma...
YP_292169 123 VRIAIAMRdgwpisdvqlaeikk------------lggkieilpftipeSSSSKFRERpq-------kVLIPKELVPLLL 183 Prochlorococcus ma...
NP_896598 119 CRLAIAPRqgwplrdqaladlkr------------lgaridllelqvpaSASSALRQSpe-------qRQIPAAVWTLLL 179 Synechococcus sp. ...
Feature 1          
1KAQ_F    188 ENGLY 192 Bacillus subtilis
2H2A_A    183 GEGLY 187 Staphylococcus aureus
NP_895287 184 EHNLY 188 Prochlorococcus marinus str. MIT 9313
NP_893562 185 KNNLY 189 Prochlorococcus marinus subsp. pastoris str. CCMP1986
NP_681968 179 EQGLY 183 Thermosynechococcus elongatus BP-1
EAL20763  326 KEGLY 330 Cryptococcus neoformans var. neoformans B-3501A
NP_486523 183 QQHLY 187 Nostoc sp. PCC 7120
NP_875989 185 KKNLY 189 Prochlorococcus marinus subsp. marinus str. CCMP1375
YP_292169 184 EENLY 188 Prochlorococcus marinus str. NATL2A
NP_896598 180 EHNLY 184 Synechococcus sp. WH 8102

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