2HHM


Conserved Protein Domain Family
IMPase

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cd01639: IMPase 
Click on image for an interactive view with Cn3D
IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled into inositol lipids; in eukaryotes IMPase plays a vital role in intracellular signaling. IMPase is one of the proposed targets of Li+ therapy in manic-depressive illness. This family contains some bacterial members of the inositol monophosphatase family classified as SuhB-like. E. coli SuhB has been suggested to participate in posstranscriptional control of gene expression, and its inositol monophosphatase activity doesn't appear to be sufficient for its cellular function. It has been proposed, that SuhB plays a role in the biosynthesis of phosphatidylinositol in mycobacteria.
Statistics
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PSSM-Id: 238817
Aligned: 75 rows
Threshold Bit Score: 204.308
Created: 9-Jul-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimerization
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2HHM: binds sulfate and an inhibitory lanthanide, which establish the location of the active site
  • Citation:PMID 1332026

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       #      #     #                         ##       
2HHM_A        7 CMDYAVTLARQAGEVVCEAIkn----emNVMLKss--pVDLVTATDQKVEKMLISSIKEKYPs---HSFIGEESVaagek 77  human
Q9HXI4        4 MLNIALRAARSAGELIFRSIerl--dviSVNEKd---aKDYVTEVDRAAEQTIVAALRKAYPt---HAIMGEEGGfiegs 75  Pseudomonas aeru...
Q9PAM0        5 AVNIMVKAARSAGNVLLRHInkl--etlHVIQKs---rMDYASDVDEMAEKVIVKELKRAYPe---YGILGEEGGlqg-- 74  Xylella fastidiosa
NP_820132     4 MLNIAIQAARNAARTIVRFVdrl--dtlDINEKt---rNDFVTQVDRLSEDEIINTIHKAYPd---HTILAEETGlqk-- 73  Coxiella burneti...
NP_871288     4 MLNIAIQAAREAGKLINKYYggiy-lseNIYQI-----NENSFDINNAVENLICNIIKKYYPnhiiLNINKEIKYnffsr 77  Wigglesworthia g...
NP_878814     4 MLNVAIIAIRKGGNFLIKQYefl---grNYTELssdhiKTLLSKIRAESNQIITTIIKKFYPl---HIIIDIKNYsntst 77  Candidatus Bloch...
NP_884523     4 MLNTAIKAARRAGTIINRASldl--erlTVARKg---pRDYVTEVDRASEEAIVEVLRTAYPd---HAVLGEEFGlqgp- 74  Bordetella parap...
ZP_00152028   4 ALNIAIKAARRAGHIINRASndl--dllKVTAKq---pNDFVTEVDKAAEAAIIQTLQEAYPn---YGILAEESGetag- 74  Dechloromonas ar...
ZP_00146737   4 MVVIAARAAEKVGKEILYAHqnrhkielDIESKg---lDGLVTRIDRFSEELTIETLKSSYPt---HSYLGEEFGmqegr 77  Psychrobacter sp...
YP_047751     4 MVVMAARAAQLVGQELLKAHqnrhkldlQVEEKg---iEGPVTRVDRYLEQLTMDTLRKSYKn---HSFLGEEFGfqegk 77  Acinetobacter sp...
Feature 1                   ######                                                              
2HHM_A       78 -siltdNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCveGKMYTARKGKGAFCnGQKLQVSQQe----- 151 human
Q9HXI4       76 --gegaDYLWVIDPLDGTTNFIHGVPHFAVSIACKYKGRLEHAVVLDPvrQEEFTASRGRGAALnGRRLRVSGRk----- 148 Pseudomonas aeru...
Q9PAM0       75 ----nhRIMWVIDPLDGTSNYLRGFPHYCISIALVENGEPTDAVIFDPlrNELFTASRGAGAILnERKIRVANRk----- 145 Xylella fastidiosa
NP_820132    74 ---yknDYTWIIDPLDGTANFIHGFPQFAISIALKYRGTLEIGLVYDPlrQELFTATRGSGAQLnNRKIRVSSCq----- 145 Coxiella burneti...
NP_871288    78 kkkeisNVKWIIDPINGYENFSTNIPHFAVSIAVQINLKTEISVIYDPikNELFNAIRGRGAQLnGYRIRTKKIk----- 152 Wigglesworthia g...
NP_878814    78 --lqnnNIYWIIESIDNDINFIKQFPFFVLSITIKHHTNIKIGVIYDPihNELFSACRGKGAQFnGYRIRPHHHknilqt 155 Candidatus Bloch...
NP_884523    75 ---eqaEFQWIIDPLDGTTNYIHGLPNYAVSIALLHRRQVTQAVVYDPsrNELFTASRGSGTFLnDRRVRVSGRi----- 146 Bordetella parap...
ZP_00152028  75 --kgdgEYQWIIDPLDGTTNFIHGMPQYAVSIALAKGGVVEQAVVFDPnrNELFTASKGGGAFLnERRIRVSRRt----- 147 Dechloromonas ar...
ZP_00146737  78 --gedaDWCWIIDPLDGTKNFVHGVPQFCVSIAVQHKGVTQHGVIYDPvrDEMFSASRGKGARLnQRRISVSERk----- 150 Psychrobacter sp...
YP_047751    78 --ghdaDWCWVIDPLDGTQNFVHGFPHFCISIAVQHKGVTQHGVIYDPvrDEMFSASRGRGAVMnQRRIRVNVRd----- 150 Acinetobacter sp...
Feature 1                                                                                    ## 
2HHM_A      152 --dITKSLLVTELgssr--tpetVRMVLSNMEKLFci------pvHGIRSVGTAAVNMCLVATGGADAYYEMg-IHCWDV 220 human
Q9HXI4      149 --sLEGALLGTGFpfrdn-qidnLDNYLNMFRSLVgq-------tAGIRRAGAASLDLAYVAAGRYDAFWEFg-LSEWDM 217 Pseudomonas aeru...
Q9PAM0      146 --dLNGTMLNTGF----------SPRERSRAHAQLkcvdallmqaEDIRRSGSAALDLAYVACGRADAYFEAg-IKVWDV 212 Xylella fastidiosa
NP_820132   146 --kLSHALIGTGFpfka---kelFPAYLKIFEAVFpq-------tSGVRRAGAAALDLAYVAAGRLDGFWEMs-LRPWDM 212 Coxiella burneti...
NP_871288   153 --nIKDIIISTIIsnek---qniNNNYDFILNNLIly-------fKNFRCTGSIALDLAYVASNRFSLFFLIksDLEKFF 220 Wigglesworthia g...
NP_878814   156 fnkIILSIVNMNInhtf---dinISNTLNNFHKKYni-------tIDLRCTGSLMLDLVYAAINRIDGCYIMyyHNTIKL 225 Candidatus Bloch...
NP_884523   147 --rYHDALLGAHWphs-----tdPDQGSGRFRAMAeg-------sAGVRRLGSTVLDLAYVACGRLDGFCGVg-LKPWDV 211 Bordetella parap...
ZP_00152028 148 --rLGESLIGTGFpyrm---fdkIDLYLSIFKELAek-------tAGQRRPGAASLDLAYVACGRYDGFWEFg-LSPWDM 214 Dechloromonas ar...
ZP_00146737 151 --tIDGGLFTTGHplerkrngeiISYAKEHYESLQkit----eagGQIRRLGSAALDLCYVAAGRFDGYFEMs-IKPWDI 223 Psychrobacter sp...
YP_047751   151 --hLENAFLAVGHpyraqrngeiVSYAEQHFASLLavt----kagAHIRRAGSAALDLAYVAAGRFDGFFEIg-LKPWDI 223 Acinetobacter sp...
Feature 1                                                 
2HHM_A      221 AGAGIIVTEaGGVLMDVt---------GGPFDLmsrRVIAAN 253 human
Q9HXI4      218 AAGALLVQEaGGLVSDFt---------GSHEFLekgHIVAGN 250 Pseudomonas aeruginosa
Q9PAM0      213 AAGMLLVREaGGYVCDFkgadaprmddKGPESC---QLVAGN 251 Xylella fastidiosa
NP_820132   213 AAGILLITEaGGIVSDFq---------GEKNYMengNVIAGN 245 Coxiella burnetii RSA 493
NP_871288   221 ISNDLIIREsGGLITDFt---------GGHDYLysgNILAGN 253 Wigglesworthia glossinidia endosymbiont of Glossina br...
NP_878814   226 ASSFLIIQEsGGLITYLdk-------nKKDNDQnskHIIVGN 260 Candidatus Blochmannia floridanus
NP_884523   212 AAGSLLVLEaGGLLADFd---------GEQGWLdtgNVLAGT 244 Bordetella parapertussis 12822
ZP_00152028 215 AAGALLISEaGGLVSDLr---------GEASYLetgNLVAGT 247 Dechloromonas aromatica RCB
ZP_00146737 224 AAGELIVTEaRGVVVDHt---------GAHNSMtsgSIFACN 256 Psychrobacter sp. 273-4
YP_047751   224 AAGELIVKEaGGIVVDSr---------GGNESYengQVLACS 256 Acinetobacter sp. ADP1

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