1MJH,7JI4,4R2L,3FG9,1MJH,1TQ8,2DUM,2GM3,3AB7,3CIS,3CIS,3FDX,3HGM,3LOQ,3QTB,3S3T,3TNJ,4R2J,4R2J,4WNY,7MQ5,3LOQ


Conserved Protein Domain Family
USP-like
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cd00293: USP-like 
universal stress protein (USP) and similar proteins
The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.
Links
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Statistics
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PSSM-Id: 467483
Aligned: 242 rows
Threshold Bit Score: 42.3343
Created: 6-Mar-2002
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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ATP binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1MJH: Escherichia coli Mj0577 binds ATP, contacts at 4A
  • Comment:Although proteins of the USP family share the alpha/beta/alpha fold for ATP binding, not all proteins from this family bind ATP.
  • Citation:PMID 9860944
  • Structure:7JI4: Staphylococcus aureus KdpD histidine kinase binds c-di-AMP, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ###     #                     ###                                           
1MJH_B         7 KILYPTDfs-eTAEIALKHVKAfkt-lkaEEVILLHVIdereikkrdifslllgvaglnksveefenelknklteeAKNK 84  Methanocaldococ...
CAA04212       3 KLLFAIDdt-eACERAAQYILDmfgkdadCTLTLIHVKpefmlygeavla--------------aydeiemkeeekAKLL 67  Wolinella succi...
AAM61243       6 RIVVVVEdk-qAARTALQWALHnll-rqgDVIVLLHVYspppr----------------------------kkkstAARL 55  thale cress
AAM98096      21 RVIVAVKasreIPKTALIWALThvv-qpgDCITLIVVVpshnsgrklwgftks--------fpmfagdcasghrksHSEA 91  thale cress
AAP04046      64 RVMVVVDes-sRSKHAMMWALThlt-nkgDLVTLLHVVspd--------------------------------deaTPSL 109 thale cress
P64649         2 NILFGISdt-qECYNAIKFAVKlahslkeVRFTLLHVSmevfiysesgmm--------------dygqtealeeekAKAL 66  Helicobacter py...
NP_001323815  66 KVMVVVDtt-sQTKNALQWALThcv-qdeDNITLLHVTrtpvgqaid--------------------etqrernsrAHEL 123 Arabidopsis tha...
XP_024533766 227 RVMVVVDds-rEAKTALLWALShvv-hklDVVTLLHVLystpcssqpfvydsqd------sraivsdktrlrseekGCEL 298 Selaginella moe...
XP_024536299  61 RVIVVVDqs-sEARLALLWALShiv-hklDVVTLLYVSqgktkf---------------------------rgeakGYQV 111 Selaginella moe...
NP_001150820  74 RVMVVVDqs-sGAKHAMLWALThva-nkgDFLTLLHVLppes-------------------------------ghsSRGA 120 Zea mays

Feature 1                                                                 ####                ## 
1MJH_B        85 MENIKkele---------------dvgfKVKDIIVVGip-heEIVKIAEDegvdIIIMGSHGktnl-----keilLGSVT 143 Methanocaldococ...
CAA04212      68 TQKFStfft---------------ekgiNPFVVIKEGep-veMVLEEAKDy--nLLIIGSSEnsfl------nkiFASHQ 123 Wolinella succi...
AAM61243      56 LRRHGynlalsfre------icdsffntNTEIIVREGdddgrMIAQVVKEigasMLLVGLHQnsf--------lyRWAIS 121 thale cress
AAM98096      92 LPEIKsdltdtcsqmilqlhdvydpnkiNVKIKIVSGsp-cgAVAAESKKaqanWVVMDKHLkqee------krcMDELQ 164 thale cress
AAP04046     110 AQSLGslcka-------------ckpevDVEALVIQGpk-laTVLSQVKKlevsVLVLGQKKsapli----sclcGPSRS 171 thale cress
P64649        67 LKQFEdafk---------------keniECESVLKSGdl-idVVLDMAKDy--dLLLIGASEsnll------yrlFISHQ 122 Helicobacter py...
NP_001323815 124 VHPLKnfcqlkkp--------nvkteivVVETAEEKGk----TIVEESKKqgagVLVLGQRKrtskwrviwkwrtKGGMG 191 Arabidopsis tha...
XP_024533766 299 IASLKnlcal-------------rqpevDVEVVVVAGer-gpTIVRQAKKldasILVLGQKKlnffq----rclrWNRDD 360 Selaginella moe...
XP_024536299 112 LNTLKdlcle-------------rrpeiEVETLVVEGdk-gpMIVGQAKKleasVLVLGQRKfgfl------wrfLRLTG 171 Selaginella moe...
NP_001150820 121 AEDASalanslgal------ckackpevEVEALVIQGpk-lpTILSQVKKleasVLVLSQRSpspf------ccfPRSSS 187 Zea mays

Feature 1                          
1MJH_B       144 ENVIkk----snKPVLVV 157 Methanocaldococcus jannaschii
CAA04212     124 DDFIqk----apIPVLIV 137 Wolinella succinogenes
AAM61243     122 GIDVarn---fnCKVMAI 136 thale cress
AAM98096     165 CNIVvmk--rsqAKVLRL 180 thale cress
AAP04046     172 EELVnrc--ingADCLTI 187 thale cress
P64649       123 NSLVeq----ssIPVVIA 136 Helicobacter pylori 26695
NP_001323815 192 GGVVeycihnsdCMAIAV 209 Arabidopsis thaliana
XP_024533766 361 QSIDyciq-hadCLTLSV 377 Selaginella moellendorffii
XP_024536299 172 DGLIdyciqnaeCLTLAV 189 Selaginella moellendorffii
NP_001150820 188 EELVeecidraeCLTLAV 205 Zea mays

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