2HGF,1BHT,1HKY,1GP9,1I8N


Conserved Protein Domain Family
PAN_APPLE

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cd00129: PAN_APPLE 
Click on image for an interactive view with Cn3D
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.
Statistics
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PSSM-Id: 238074
Aligned: 6 rows
Threshold Bit Score: 67.722
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative binding site
Evidence:
  • Comment:charged pocket believed to be general protein/carbohydrate binding site in diverse family members
  • Citation:PMID 9493272
  • Structure:1BHT_A, binds SO4 ion
  • Comment:heparin thought to bind at sulfate ion position
  • Citation:PMID 9817840

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          # #                #                                       
2HGF        9 IHEFKKsakTTLikidpalkIKTKkv------nTADQCANRCtrnkglpFTCKAFVFDka-----rKQCLWFPfnsmssg 77  human
1BHT_A      5 IHEFKKsakTTLikidpalkIKTKkv------nTADQCANRCtrnkglpFTCKAFVFDka-----rKQCLWFPfnsmssg 73  human
AAF16627  344 ADSICNgkeGFAklk--rvkIPNTsavnvdmniTLKECEQRClk----nCSCVAYASAyhesqdgaKGCLTWHgnm--ld 415 thale cress
1HKY_A      9 VKLTCYqngVSFtgg---kaISEAka------aSSQACQELCek----dAKCRFFTLAs-------GKCSLFAdda---a 65  Eimeria tenella
1GP9_A      6 VHEFKKsakTTLikidpalkIKTKkv------nTADQCANRCtrnkglpFTCKAFVFDka-----rKQCLWFPfnsmssg 74  human
1I8N_A     44 EDCWSKrpgWKLpd----nlLTKTef------tSVDECRKMCees-avePSCYILQINte-----tNECYRNNegdv-tw 106 Mexican leech
Feature 1                     
2HGF       78 vKKEFgh-efDLYENK 92  human
1BHT_A     74 vKKEFgh-efDLYENK 88  human
AAF16627  416 tRTYLss-gqDFYLRV 430 thale cress
1HKY_A     66 lRPTKsd-gaVSGNKR 80  Eimeria tenella
1GP9_A     75 vKKEFgh-efDLYENK 89  human
1I8N_A    107 sSLQYdqpnvVQWHLH 122 Mexican leech

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