2IYA


Conserved Protein Domain Family
MGT

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TIGR01426: MGT 
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glycosyltransferase, MGT family
This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]
Statistics
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PSSM-Id: 273616
Aligned: 9 rows
Threshold Bit Score: 517.7
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IYA_A        18 FNIPGHGHVNPSLGIVQELVARGHRVSYAITDEFAAQVKAAGATPVVYDSILPk--eSNPEE-----Swp-eDQESAMGL 89  Streptomyces la...
AAK80662       7 MNFPGYGHVNPTLGLVDELVKRGEEVYYFCTDEFKESIEAAGAKFISYGERMS----NFKNAnktagNr---SYADIITK 79  Clostridium ace...
AAK76791       7 LGIPAYGHVNPTLGIISELVKRGQEVTYFCTEEFRERIEKTGAIFKDYGSAMDp---SNRKHhfsasNmtkeTLIAIIEK 83  Clostridium ace...
BAA84592       8 MSAPFWGHVFPSLAVAEELVHRGHHVTFVTGAEMADAVRSVGADFLRYESAFEg--vDMYR------LmteaEPNAIPMT 79  Streptomyces av...
CAC33935      28 FSIALHGHVNPSLEVIRELVARGHRVTYAIPPLLADKVAEAGAEPKLWNSTLPg--pDADPEaw------gsTLLDNVEP 99  Streptomyces co...
AAC12648      18 FNIPGHGHVNPSLGIVQGLVARGQRVSYGITDEFGAQVKAGRATAVVYGFILPe--eFNPEEll------aeDQGSRWAC 89  Streptomyces an...
CAB52955       7 LNIGMHGHINPTLPVAAELVRRGHTVTYHTFPAFREEIAATGANVRLYPGGDQp----LPDp---------pAPITLMEA 73  Streptomyces co...
WP_003232783   9 INIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAPAVQQAGGEALIYHTSLNid-pKQIRem-------meK-NDAPLS 79  Bacillus subtilis
AAD41824      64 FILPAAGHVNPTLGVAEELAARGHRVTYALPEDMADRAVRVGARAVTYPLDRErfraDMVPKeesdeYtdegEFLKVLEW 143 Streptomyces fr...
2IYA_A        90 FLDEAVRVLPQLEDAYADDRPDLIVYDIASw--PAPVLGRKWDIPFVQLSPTFVAYeGFEEDV---------------Pa 152 Streptomyces la...
AAK80662      80 IIGMTECEIEDILKKIKGMKFDYVVHCSMFc--AGNIIAQILKVPSISSFAVFATRkEVMKMQy--------------S- 142 Clostridium ace...
AAK76791      84 SLDICEKAIESVLDKTNGTKFDYIGYAAACp--FGSLLAQILKLPSFSSFAIFATPdEIMPKSl--------------E- 146 Clostridium ace...
BAA84592      80 LYDEGMSMLRSVEEHVGKDVPDLVAYDIATslnVGRVLAASWSRPAMTVIPLFASNgRFSTMQ---------------S- 143 Streptomyces av...
CAC33935     100 FLADAIQSLPQLAQAYEGDEPDLVLHDIASy--TARVLGRRWEVPVISLSPCMVAWeGYEQEV----------------- 160 Streptomyces co...
AAC12648      90 SLAEAFRVLPQLRTATPTTGRDLIVYDIASw--PAPVLGRKWDIPFVQLSPTSVAYeGFEEDVpavqdptadrgeeaaA- 166 Streptomyces an...
CAB52955      74 LARTSLDLLPAVLADLRDDRPDLIVHDSACp--WGALAARVLGLPAVSSFTTFAYNrHVPSPTr---------------- 135 Streptomyces co...
WP_003232783  80 LLKESLSILPQLEELYKDDQPDLIIYDFVAl--AGKLFAEKLNVPVIKLCSSYAQNeSFQLGN----------------- 140 Bacillus subtilis
AAD41824     144 LLDTTADTLPLLESAFAEDRPDVVANDPSTf-wTGLLLAGKWDIPVIRSTPSYASN-EHWALH---------------P- 205 Streptomyces fr...
2IYA_A       153 vqdptadrgeeaaaPAGTGDAEEGAeaed--------glvrFFTRLSAFLEEHGVDTPATEFLIAPNR--CIVALPRTFQ 222 Streptomyces la...
AAK80662     143 --------------PITEKELESNPivs-----------raYSEAKSRIEKRYFVKMPAISELMACRGdlNIAYTAKEFV 197 Clostridium ace...
AAK76791     147 --------------GITEESMKDTPim------------ekYMKLKYGLKEKYDIELPEIKKLFFNKGdvNFAYTSKYFI 200 Clostridium ace...
BAA84592     144 --------------VLDPDSAQVSAppprfseqmelfglgaLVPRLAELLVSRGIT-EPVDDFLSGPEdfNLVCLPRAFQ 208 Streptomyces av...
CAC33935     161 ----------------GEPMWEEPRkter---------gqaYYARFHAWLEENGITDHPDPFIGRPDR--SLVLIPKALQ 213 Streptomyces co...
AAC12648     167 --------------PAGTGDAEEGAeaed--------glvrFFTRLSAFLEEHGVDTPATEFLIAPNR--CIVGCRAPSQ 222 Streptomyces an...
CAB52955     136 ---------------ASRELLAGAAarpr--------nlagYVGARLALRRRFAATGVPLVDLADIRQplNLVYTSRAFQ 192 Streptomyces co...
WP_003232783 141 -----------------EDMLKKIRe---------------AEAEFKAYLEQEKLPAVSFEQLAVPEAl-NIVFMPKSFQ 187 Bacillus subtilis
AAD41824     206 --------------PFEPGAAQVDPal------------ieLTARAEKLLKEHGTTSDPVAFAATVQSgpGLFYMPRYFQ 259 Streptomyces fr...
2IYA_A       223 IKGDTVGDN-YTFVGPTYGDRSHQGT--WEGPGDGRPVLLIALGSAFTDHLD-FYRTCLSAVDGLDw-HVVLSVGRFVDP 297 Streptomyces la...
AAK80662     198 SNIEYYDDS-FKFIGPPIYKRKENLDf-PFEKLKNKKVIYISLGTVFNNTNSnLYNIFFEAFGGSD--VVVVMSAYNIDT 273 Clostridium ace...
AAK76791     201 PNIQYYDDS-FKFIGPPIYDRKEDLSnfPYEEIKDKKVIYISLGTVYSNFDIkLYETFFNAFKNED--VVVVMTAYKVDL 277 Clostridium ace...
BAA84592     209 YAGDTFDER-FAFVGPCLGKRRGLGE--WTPPGSGHPVVLISLGTVFNRQLS-FFRTFVRAFTDVPv-HVVISLGKGVDP 283 Streptomyces av...
CAC33935     214 PHADRVDETtYTFVGACQGDRTAEGD--WARPEGAEKVVLVSLGSAFTKQPA-FYRECVRAFGELPgwHTVLQVGRHVDP 290 Streptomyces co...
AAC12648     223 IKGDTVGDN-YTFVGPTYGDRSHQGT--WEGPGHGRPVLLIALGSAFTDHLD-FYRTCLSAVDGLDw-HVVLSVGRFVDP 297 Streptomyces an...
CAB52955     193 PAVEEFDRS-YRFVGPSIGARPDDPS--FPVNRLRDPVLYASLGTVFNADPL-LLRTFATALSPLA--GTVVVSTGQTDP 266 Streptomyces co...
WP_003232783 188 IQHETFDDR-FCFVGPSLGERKEKES--LLIDKDDRPLMLISLGTAFNAWPE-FYKMCIKAFRDSSw-QVIMSVGKTIDP 262 Bacillus subtilis
AAD41824     260 YAGETFDDR-HHFVGPCAPRASFHGT--WQRPEDGRPLVMVSLGTIYNERPG-IFRACVEAFRDRPw-NILLVLGGGLGA 334 Streptomyces fr...
2IYA_A       298 ADLGeVPPNVEVHQWVPQLDILTKASAFITHAGMGSTMEALSNAVPMVAVPQIAEQTMNAERIVELGLGRHIPRDQVTAE 377 Streptomyces la...
AAK80662     274 SNFN-IPKNFIVRNYVPQTEILKYADAAITHAGMNSTSDLIYNKVPFVAIPIGADQLYMASRAKELGAAIVLNKDKLTAK 352 Clostridium ace...
AAK76791     278 SQFD-IPKNFVVRNYISQTEILKYANAAVTHSGMNSTNDLLFNSVPFVAIPLGADQPYMASRTADLGACIKLDIDTLTPE 356 Clostridium ace...
BAA84592     284 DVLRpLPPNVEVHRWVPHHAVLEHARALVTHGGTGSVMEALHAGCPVLVMPLSRDAQVTGRRIAELGLGRMVQPEEVTAT 363 Streptomyces av...
CAC33935     291 AELGdVPDNVEVRTWVPQLAILQQADLFVTHAGAGGSQEGLATATPMIAVPQAADQFGNADMLQGLGVARTLPTEEATAK 370 Streptomyces co...
AAC12648     298 ADLGeVPPNVEVHQWVPQLDILTKASAFITHAGMGSTMEALSNAVPMVAVPQIAEQTMNAERIVELGLGRHIPRDQVTAE 377 Streptomyces an...
CAB52955     267 AALGeLPGNVLARRSVPQLEVLDRAALFITHGGMNSVNEALFAGVPLLLVPQGADQPMVARRVVELGAGLSIRTENITED 346 Streptomyces co...
WP_003232783 263 ESLEdIPANFTIRQSVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYLPKEEVTVS 342 Bacillus subtilis
AAD41824     335 GDLGpLPENVLVRDFVPLGDVLPHTDLLVNHGGTSTAMEALAHGVPIVAMPEMPEPRATARRIAELDLGDWLLPGEVTAE 414 Streptomyces fr...
2IYA_A       378 KLREAVLAVASDPGVAERLAAVRQEIREAGGARAAADILEGILAE 422 Streptomyces lavenduligriseus
AAK80662     353 ELRESVNKVMVDASYLENIEKIRDVFREAGGYRKGAEEIFKFKAE 397 Clostridium acetobutylicum ATCC 824
AAK76791     357 LLRNSVYEVMTNQNYMENIRKINNSFRESGGYKRAAEEVLKLKAR 401 Clostridium acetobutylicum ATCC 824
BAA84592     364 TLRRHVLDIISDDAITRQVRQMQRATVEAGGALRAADETERFLRR 408 Streptomyces avermitilis
CAC33935     371 ALRTAALALVDDPEVAARLKEIQARMAQEGGTRRAADLIEAELAA 415 Streptomyces coelicolor A3(2)
AAC12648     378 KLREAVLAVASDPGVAERLAAVRQEIREAGGARAAADILEGILAE 422 Streptomyces antibioticus
CAB52955     347 SVRAVARRLLEDSRYRAATSGLRATQHEAGGYRRAADELEGYLRP 391 Streptomyces coelicolor A3(2)
WP_003232783 343 SLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKK 387 Bacillus subtilis
AAD41824     415 KLSGIAQRVLTDDRIRKGLDRMRGEIRRAGGPAVAADVIEGLLSP 459 Streptomyces fradiae
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