4PH6,2EGZ


Conserved Protein Domain Family
aroD
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TIGR01093: aroD 
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3-dehydroquinate dehydratase, type I
This model detects 3-dehydroquinate dehydratase, type I, either as a monofunctional protein or as a domain of a larger, multifunctional protein. It is often found fused to shikimate 5-dehydrogenase (EC 1.1.1.25), and sometimes additional domains. Type II 3-dehydroquinate dehydratase, designated AroQ, is described by the model TIGR01088. [Amino acid biosynthesis, Aromatic amino acid family]
Links
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Statistics
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PSSM-Id: 273439
Aligned: 13 rows
Threshold Bit Score: 228.036
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4PH6_A     20 KIVVPIVAPTAEDILAEATASQt-LDCDLVEWRLDYYENVADFS---D---VCNLSQQVMERL---GQKPLLLTFRTQKE 89   Enterococcus faec...
O87007     17 KIIVSLMAKDIARVKSEALAYRe-TDFDILEWRVDHFADLSNVE---S---VMAAAKILRETM---PEKPLLFTFRSAKE 86   Shigella dysenteriae
P36923     17 KIVVPIVAPTAEDILAEATASQt-LDCDLVEWRLDYYENVADFS---D---VCNLSQQVMERL---GQKPLLLTFRTQKE 86   Enterococcus faec...
CAB84887   29 KIAVPLVARDAAVLSAVLDQIKn-LPFDIVEFRADFLECAGSIG---E---VLRHTQTVRDAL---PDKPLLFTFRRHGE 98   Neisseria meningi...
Q59087     36 KTLVPITAKTREQALAQAKVIAenKDADIAEFRIDLLEFASDTK---K---VIALGQELNQIL---KDKPLLATIRTSNE 106  Acinetobacter sp....
O66440      2 LIAVPLDDTNFSENLKKAKE----KGADIVELRVDQFSDTSLNY---V---KEKLEEVHS------QGLKTILTIRSPEE 65   Aquifex aeolicus VF5
Q58849      1 MICLPVVEDSVEKAIKTAEKYLe-I-ADIVEFRIDMLKEVSEED-----------IEKF-------AKYPCIITVRADWE 60   Methanocaldococcu...
O30011      1 --mKLVATLSSPEELELAEK------ADVVELRIDLFDFSGAR-----------------------VDKEKILTCRRVSD 49   Archaeoglobus ful...
P08566   1076 SAFVCLTFDDLTEQTENLTPIC--YGCEAVEVRVDHLANYSADF----------VSKQLSILRkatDSIPIIFTVRTMKQ 1143 Saccharomyces cer...
CAB75770 1054 STFLTLNYPRIEDALPTLRDVT--VGCDAIEVRVDYLKDPKSSNgisS---LDFVAEQISLLRc-sTTLPIIFTIRTISQ 1127 fission yeast
S48698      6 LICVPIMGETVEKMVVDIQKAKl-NGADLVEIRLDSLSTFNPHQ---D---LNTFIQQH-------HSLPFLFTYRPIWE 71   pea
CAA28836 1052 SFFASLTLPDLREAGDILEEVC--VGSDAVELRVDLLKDPASNN---DipsVDYVVEQLSFLRs-rVTLPIIFTIRTQSQ 1125 Aspergillus nidulans
2EGZ_A      2 LIAVPLDDTNFSENLKKAKe----KGADIVELRVDQFSDTSLNY---V---KEKLEEVHSQ------GLKTILTIRSPEE 65   Aquifex aeolicus

4PH6_A     90 GGEMAFSEENYFALYHELVKKGALDLLDIELFANPLAADTLIHeaKKAGIKIVLCNHDFQKTPSQEE---IVARLRQMQM 166  Enterococcus faec...
O87007     87 GGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAyaHAHDVKVVMSNHDFHKTPEAEE---IIARLRKMQS 163  Shigella dysenteriae
P36923     87 GGEMAFSEENYFALYHELVKKGALDLLDIELFANPLAADTLIHeaKKAGIKIVLCNHDFQKTPSQEE---IVARLRQMQM 163  Enterococcus faec...
CAB84887   99 GGSFPCSDDYYFELLDALIESRLPDIIDIELFSGETAVRCAVAnaQKNGIAALLCNHEFHRTPPQEE---IVCRLKQMED 175  Neisseria meningi...
Q59087    107 GGKLKVTDQEYEKIYSEYLKKPFMQLLDIEMFRDQAAVAKLTKlaHQKKVLVVMSNHDFDKTPSEQE---IVSRLLKQDQ 183  Acinetobacter sp....
O66440     66 GGREVKNREELFEEL-----SPLSDYTDIELSSRGLLVK-LYNitKEAGKKLIISYHNFELTPPNWI---IREVLREGYR 136  Aquifex aeolicus VF5
Q58849     61 GGYWKGNNEERLNLIKKAIECN-AKFVDIELREEKNKELVKFRdeIGSKTKIIISYHDFEKTPSKEK---LVEIVEKALS 136  Methanocaldococcu...
O30011     50 GGKFEGDERERIEKMKRAFDSLNPDYVDLESDLPDSa--------FDFNCRIIESYHNFIRTPDYSE---LKGIVEGRR- 117  Archaeoglobus ful...
P08566   1144 GGNFPDEEFKTLRELYDIALKNGVEFLDLELTLPTDIQYEVIN--KRGNTKIIGSHHDFQGLYSWDDa-eWENRFNQALT 1220 Saccharomyces cer...
CAB75770 1128 GGLFPNDKEEEAKELMLSAMRYGCDFVDVELGWSSETINILYQ--HKGYTKLIMSWHDLSGTWSWARpheWMQKVELASS 1205 fission yeast
S48698     72 GGKYDGDENRRLDALRLAVE-LGADYVDIELKVAHEFY-DSIRgkMFNKTKVIVSSHNYQYTPSVED---LGDLVARIQA 146  pea
CAA28836 1126 GGRFPDNAHDAALELYRLAFRSGCEFVDLDIAFPEDMLRAVTe--MKGFSKIIASHHDPKGELSWANm-sWIKFYNKALE 1202 Aspergillus nidulans
2EGZ_A     66 GGREVKNREELFEEL-----SPLSDYTDIELSSRGLLVK-LYNitKEAGKKLIISYHNFELTPPNWI---IREVLREGYR 136  Aquifex aeolicus

4PH6_A    167 RqADICKIAVMPQDATDVLTLLSATNEMYTHYaSVPIVTMSMGQLGMISRVTGQLFGSALTFGs-A--QQASAPGQLSVQ 243  Enterococcus faec...
O87007    164 FdADIPKIALMPQSTSDVLTLLAATLEMQEQYaDRPIITMSMAKTGVISRLAGEVFGSAATFGa-V--KKASAPGQISVN 240  Shigella dysenteriae
P36923    164 RqADICKIAVMPQDATDVLTLLSATNEMYTHYaSVPIVTMSMGQLGMISRVTGQLFGSALTFGs-A--QQASAPGQLSVQ 240  Enterococcus faec...
CAB84887  176 CgADICKIAVMPQSAEDVLTLLSATLKA-KELaAKPIVTMSMGQTGAVSRLAGQVFGSSITFGs-G--TQNSAPGQIGVS 251  Neisseria meningi...
Q59087    184 MgADILKIAVMPKSKQDVFTLMNATLKV-SEQsTKPLLTMSMGRLGTISRIATANMGGSLSFGm-I--GEASAPGQIDVT 259  Acinetobacter sp....
O66440    137 Y-GGIPKIAVKANSYEDVARLLCISRQVE-----GEKILISMGDYGKISRLAGYVFGSVITYCs-L--EKAFAPGQIPLE 207  Aquifex aeolicus VF5
Q58849    137 I-GDIAKFATMANSKEDVLNILEVINKYP-----GKIIGIGMGEKGKLTRILGVYFGSILTFAsyK--GKSSAPGQVDID 208  Methanocaldococcu...
O30011    118 --GDLVKIATMGKSKRDVETIVRILTNYD------DVVAFLMGERFSFTRVLAAYLGSPFIYCy-V--GSPKAPGQISLD 186  Archaeoglobus ful...
P08566   1221 LdVDVVKFVGTAVNFEDNLRLEHFR---DTHK-NKPLIAVNMTSKGSISRVLNNVLTPVTSDL--L--PNSAAPGQLTVA 1292 Saccharomyces cer...
CAB75770 1206 Y-ADVIKLVGMANNLNDNLELEEFRTRITNSM-DIPLILFNMGRFGQLSRILNKFMTPVTHPL--L--PSKAAPGQLTVK 1279 fission yeast
S48698    147 TgADIVKIATTAVEITDVARMFQILVHSQ-----VPFIGLVMGDRGLVSRVLCAKFGGYLTFGt-LesGVVSAPGQPTIK 220  pea
CAA28836 1203 Y-GDIIKLVGVARNIDDNTALRKFKNWAAEAH-DVPLIAINMGDQGQLSRILNGFMTPVSHPs--L--PFKAAPGQLSAT 1276 Aspergillus nidulans
2EGZ_A    137 YgG-IPKIAVKANSYEDVARLLCISRQVE-----GEKILISMGDYGKISRLAGYVFGSVITYCs-L--EKAFAPGQIPLE 207  Aquifex aeolicus

4PH6_A    244 VLRNYL 249  Enterococcus faecalis V583
O87007    241 DLRILL 246  Shigella dysenteriae
P36923    241 VLRNYL 246  Enterococcus faecalis V583
CAB84887  252 ALRATL 257  Neisseria meningitidis Z2491
Q59087    260 ALKQFL 265  Acinetobacter sp. ADP1
O66440    208 EMVELR 213  Aquifex aeolicus VF5
Q58849    209 TLKEIW 214  Methanocaldococcus jannaschii DSM 2661
O30011    187 DAREII 192  Archaeoglobus fulgidus DSM 4304
P08566   1293 QINKMY 1298 Saccharomyces cerevisiae S288c
CAB75770 1280 QLNEAR 1285 fission yeast
S48698    221 DLLHLY 226  pea
CAA28836 1277 EIRKGL 1282 Aspergillus nidulans
2EGZ_A    208 EMVELR 213  Aquifex aeolicus
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