1QWR


Conserved Protein Domain Family
manA
?
TIGR00218: manA 
Click on image for an interactive view with Cn3D
mannose-6-phosphate isomerase, class I
The names phosphomannose isomerase and mannose-6-phosphate isomerase are synonomous. This family contains two rather deeply branched groups. One group contains an experimentally determined phosphomannose isomerase of Streptococcus mutans as well as three uncharacterized paralogous proteins of Bacillus subtilis, all at more than 50 % identity to each other, plus a more distant homolog from Archaeoglobus fulgidus. The other group contains members from E. coli, budding yeast, Borrelia burgdorferi, etc. [Energy metabolism, Sugars]
Links
?
Statistics
?
PSSM-Id: 272966
Aligned: 8 rows
Threshold Bit Score: 308.594
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
1QWR_A         8 PIFLTPVFK---EkIWG----GTALRDRFGYSIPSES------TGECWAIsAHPKGPSTVANgpyKGKTLIELWEEHR-E 73  Bacillus subtilis
AAB64536       2 SNKLFRLDAgyqQyDWGkigsSSAVAQFAAHSDPSVQieqdkpYAELWMG-THSKMPSYNHE---SKESLRDIISKNPsA 77  baker's yeast
P39841         5 PIFLTPVFK---EkIWG----GTALRDRFGYSIPSES------TGECWAIsAHPKGPSTVANgpyKGKTLIELWEEHR-E 70  Bacillus subtil...
WP_003242491   4 PLFLEPVFK---ErLWG----GTKLRDAFGYAIPSQK------TGECWAVsAHAHGSSSVKNgplAGKTLDQVWKDHP-E 69  Bacillus subtilis
WP_003232833   5 PLFFKPVFK---ErIWG----GTALAD-FGYTIPSQR------TGECWAFaAHQNGQSVVQNgmyKGFTLSELWEHHR-H 69  Bacillus subtilis
P00946         2 QKLINSVQN---Y-AWGs---KTALTELYGMENPSSQp-----MAELWMG-AHPKSSSRVQNaagDIVSLRDVIESDKsT 68  Escherichia col...
WP_010877549   4 PSFIFQAQEnlvErPWG----GEWIALLKGFRQSG--------IGESWEFsAHTSRPSTVLVk-gQQLSMIELFSKHRdE 70  Archaeoglobus f...
WP_002661081   4 EDNIFLMKNnikEyDWGg---INFIPNLLGDKIDGKP------KAEMWLG-AHKTFSSKILYk-nEYVLLSDFLEDHK-E 71  Lyme disease sp...

1QWR_A        74 VFGGVEGD-----R--FPLLTKLLDVKEDTSIKVHPD--------------------------DY--------------- 105 Bacillus subtilis
AAB64536      78 MLGKDIIDkfhatNe-LPFLFKVLSIEKVLSIQAHPDkalgkilh----------aqdpknypDDnhkpemaiavtdfeg 146 baker's yeast
P39841        71 VFGGVEGDr-------FPLLTKLLDVKEDTSIKVHPD--------------------------DY--------------- 102 Bacillus subtil...
WP_003242491  70 IFGFPDGK-----V--FPLLVKLLDANMDLSVQVHPD--------------------------DD--------------- 101 Bacillus subtilis
WP_003232833  70 LFGQLEGD-----R--FPLLTKILDADQDLSVQVHPN--------------------------DE--------------- 101 Bacillus subtilis
P00946        69 LLGEAVAKr---fGe-LPFLFKVLCAAQPLSIQVHPNkhnseigfakenaagipmdaaernykDPnhkpelvfaltpfla 144 Escherichia col...
WP_010877549  71 LLGRAAEK-----FskFPILVRLIDAASPTQVHVHPS--------------------------DK--------------- 104 Archaeoglobus f...
WP_002661081  72 LLGCNDe---------FPFLLKVLSANKPLSIQIHPSkdialkgyesennkgidindpkrtykDKnpkieliyalsd--- 139 Lyme disease sp...

1QWR_A       106 ----------------YAGEN-----------------------EEGE-----LGKTECWYIIDCKE----NAEIIYGHT 137 Bacillus subtilis
AAB64536     147 fcgfkplqeiadelkrIPELRnivgeetsrnfieniqpsaqkgsPEDEqnkklLQAVFSRVMNASDDkikiQARSLVERS 226 baker's yeast
P39841       103 ----------------YAGEN-----------------------EEGE-----LGKTECWYIIDCKE----NAEIIYGHT 134 Bacillus subtil...
WP_003242491 102 ----------------YAKLH-----------------------ENGD-----LGKTECWYIIDCKD----DAELILGHH 133 Bacillus subtilis
WP_003232833 102 ----------------YANIH-----------------------ENGE-----LGKTECWYIIDCQK----DAEIIYGHN 133 Bacillus subtilis
P00946       145 mnafrefseivsllqpVAGAHpaiah--------------flqqPDAEr----LSELFASLLNMQGEeksrALAILKSAL 206 Escherichia col...
WP_010877549 105 ----------------AAESL-----------------------GEAE-----GGVESAWLVFNKGK----AYAGFKEDV 136 Archaeoglobus f...
WP_002661081 140 ----fyalkgflpldeIKKIY-----------------------EILEln-fdFQSHKDFVKTIFDLqmyeLEKIIEKIL 191 Lyme disease sp...

1QWR_A       138 ARS-----KTELVTXI--------NS-GDWE--GLLRRIKIKPGDFYYVPSGTLHA-LcKGALVLETQQNSDATYRVYDY 200 Bacillus subtilis
AAB64536     227 KNSpsdfnKPDLPELIqrlnkqfpDDvGLFCgcLLLNHCRLNAGEAIFLRAKDPHA-Y-ISGDIMECMAASDNVVRAGFT 304 baker's yeast
P39841       135 ARS-----KTELVTMI--------NS-GDWE--GLLRRIKIKPGDFYYVPSGTLHA-LcKGALVLETQQNSDATYRVYDY 197 Bacillus subtil...
WP_003242491 134 AST-----KEEFKQRI--------ES-GDWN--GLLRRIKIKPGDFFYVPSGTLHA-LcKGTLVLEIQQNSDTTYRVYDY 196 Bacillus subtilis
WP_003232833 134 ATT-----KEELTTMI--------ER-GEWD--ELLRRVKVKPGDFFYVPSGTVHAiG-KGILALETQQNSDTTYRLYDY 196 Bacillus subtilis
P00946       207 DSQ-----QGEPWQTIrlisefypEDsGLFSp-LLLNVVKLNPGEAMFLFAETPHA-Y-LQGVALEVMANSDNVLRAGLT 278 Escherichia col...
WP_010877549 137 KIE-----ELEEKLKE--------ED-FDFK--TLLNTFETTPYDTFVIRPGIPHA-G-EGLRVLEVSSNSTLAYFFNEN 198 Archaeoglobus f...
WP_002661081 192 KNLdlidnFRGYWFNEiyn--iygIDvGLLVf-LGMNILKLKPGEVVYTNSQEVHA-Y-LKGDCIELMTNSDNVIRAGLT 266 Lyme disease sp...

1QWR_A       201 DrldsngspRELHFAKAVNAATVPHVDGYIDESTESRK------GITIKTFVQGEYFSVYKWDINGEA---EXAQDESFL 271 Bacillus subtilis
AAB64536     305 P--------KFKDVKNLVSMLTYTYDPVEKQKMQPLKFdrssgnGKSVLYNPPIEEFAVLETTFDEKLgqrHFEGVDGPS 376 baker's yeast
P39841       198 DrldsngspRELHFAKAVNAATVPHVDGYIDESTESRK------GITIKTFVQGEYFSVYKWDINGEA---EMAQDESFL 268 Bacillus subtil...
WP_003242491 197 DrcndqgqkRTLHIEKAMEVITIPHIDKVHTPEVKEVG------NAEIIVYVQSDYFSVYKWKISGRA---AFPSYQTYL 267 Bacillus subtilis
WP_003232833 197 DrkdaegklRELHLKKSIEVIEVPSIPERHTVHHEQIE------DLLTTTLIECAYFSVGKWNLSGSA---SLKQQKPFL 267 Bacillus subtilis
P00946       279 P--------KYIDIPELVANVKFEAKPANQLLTQPVKQ------GAELDFPIPVDDFAFSLHDLSDKE---TTISQQSAA 341 Escherichia col...
WP_010877549 199 D------------WEKVKKVLNTKKVEEFEVKGKKG--------------MAETENFGLEVVDVTGTA---EIKTGGVMN 249 Archaeoglobus f...
WP_002661081 267 T--------KYIDKDEMLRVGQFEEGKLSFLNPDFQDN--------FSVFRLPNTNLKLIQKKINENI----CINRNSAM 326 Lyme disease sp...

1QWR_A       272 ICSVIEGSGLLKYEDKTCPLKKGDHFILPAQXpDFTIKGTcTLIVSH 318 Bacillus subtilis
AAB64536     377 ILITTKGNGYIKADGQKLKAEPGFVFFIAPHL-PVDLEAEdEAFTTY 422 baker's yeast
P39841       269 ICSVIEGSGLLKYEDKTCPLKKGDHFILPAQMpDFTIKGTcTLIVSH 315 Bacillus subtilis subsp. subtilis str. 168
WP_003242491 268 LGSVLSGSGRIINNGIQYECNAGSHFILPAHFgEFTIEGTcEFMISH 314 Bacillus subtilis
WP_003232833 268 LISVIEGEGRMISGEYVYPFKKGDHMLLPYGLgEFKLEGYaECIVSH 314 Bacillus subtilis
P00946       342 ILFCVEGDATLWKGSQQLQLKPGESAFIAANEsPVTVKGH-GRLARV 387 Escherichia coli K-12
WP_010877549 250 ILYAAEG-YFILRGKETADLHRGYSCLVPASTdSFTVESErGKIVRI 295 Archaeoglobus fulgidus
WP_002661081 327 VLLVLNG---CVSINKSLNLKKGESIFIGKKAeNLFIDGDgEAFIAG 370 Lyme disease spirochete
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap