Conserved Protein Domain Family
hisD

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TIGR00069: hisD 
histidinol dehydrogenase
This model describes a polypeptide sequence catalyzing the final step in histidine biosynthesis, found sometimes as an independent protein and sometimes as a part of a multifunctional protein. [Amino acid biosynthesis, Histidine family]
Statistics
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PSSM-Id: 272887
Aligned: 57 rows
Threshold Bit Score: 462.758
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P00815       388 VNPIIENVRDKGNSALLEYTEKFDGV--KLSNPVLNAPFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTetL-EVET 464 Saccharomyces c...
P73058        33 AKEVIEQVKMEGDAGVLHYSRQFDFAgaTAENLRVSEAEFAEAEKLVDPELRRAVEHAFRNIEKVHAGQMPPpmH-LAEI 111 Synechocystis s...
Q483H8        36 VKPIIENVKLNGDKALSEYAKKFDKAevSTDQIQVTQAEFDEAFTLVDEEVIQTLSYSIDNIKKFHEAQMPEemW-MKQI 114 Colwellia psych...
Q9X0D1        30 VKEIIRRVKEEGDRALEEFLKRFEKHpvGIENLRVTEKEISEA--QVEEEFVETIKIVIEDLKEFHRRQEERs-F-FFTT 105 Thermotoga mari...
Q3ZXL7        44 VNGIIADVRKQGDEAVLGYTLKFDRA--NLSKLEVGQPEIQQAASEIPAELFEALQLAASQIRAYHRFQKEAv-WkTAEI 120 Dehalococcoides...
Q5JFR5         8 VREILEDIRRRGLEALREYSERFDNY---SGPFRVSEGEFEEAEELVPEEDKRVIEETMERLWEYHARQFRD--V-ELYI 81  Thermococcus ko...
Q4A044        26 VKDICENVRLHGDDALRNYNQQFDQV--ETCNLEVAYQTLENAYNRLDSDLREALQQSHARIQSYQESIK----W---TK 96  Staphylococcus ...
O33775        21 VKDIIESVKTKGDNALYELTEKLDKV--KIDNIKAREEELKTQASKLDPKVKQAIDTAYEQLKAFHEMLVPPn---IGGG 95  Sulfolobus solf...
Q8ZY17        12 VWKIVDDVQSGGLKAALEYSKRLDGV--------APEPHLVTPRQGGDPEVVSAALAAAKSLEALYSRISPPa---AVDF 80  Pyrobaculum aer...
WP_011680218  32 VTDIIKNVRANGDEALKEYGEKFDGV--TLDNLKVTDSQIEEAFNQVNPAVIKALEKAADNIRSFHKLEIGEs-F-EDNP 107 Leuconostoc mes...
P00815       465 QPG-VLCSRFPRPIEKVGLYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPrKSDGKVSPEVVYVAEKVGASKIVLAG 543 Saccharomyces c...
P73058       112 EPG-VFAGEKITPLPTVGLYVPRGKGAFPSMMLMLAVPARVAGVKKIVVCTPP-DKEGKVEPVSLVTARMAGVDEVYKLG 189 Synechocystis s...
Q483H8       115 RPG-CYAGDRFTPINAVACYIPRGKGSFPSVAIMTAVPAIVAGVPTAIIITPP-GTDGKVDAATLVVAKLVGIDKVFKCG 192 Colwellia psych...
Q9X0D1       106 KGG-SFLGEMVVPLESVGIYVPGGKVPYFSTLLMCAVPAIVAGVERIAVTTPP-NENGGISPYILKTCEILGLKEIYRMG 183 Thermotoga mari...
Q3ZXL7       121 MQG----KQLIRPLERVGLYVPGGKAFYPSTVLMTAIPAREAGVKEIILVTPP-GANGKIPAPTLAAAQIAGVDRIFACG 195 Dehalococcoides...
Q5JFR5        82 KRG-SLYGLIYRPIGRIGIYVPGGK-PLPSTLMMVGIPARIAGVREIAVTTPPk--DGKVNPYVLYVAKLLGIEEVYKLG 157 Thermococcus ko...
Q4A044        97 QQGtSDCYELYHPLERVGVYVPGGKASYPSTVLMTVTLAKVAGVKNISVVTPPq-lNG-IPDIVLAACYIAGVDNVYQVG 174 Staphylococcus ...
O33775        96 YQG-ISFGVIWRSIEKIGIYVPSGKYSYPSTLLMAGIPAKVAKVKEIYVASPP-TQEGTVNPALAYVAIKLGVNEVYKIG 173 Sulfolobus solf...
Q8ZY17        81 YGG-ILRQILWKPVRRAALYVP---ARYISTLVMLAVPARLAGVEEVYVVTPP---RG-VSEELLAVAKELGVKAVLALG 152 Pyrobaculum aer...
WP_011680218 108 SNG-VIRGTKVTPLSAVGIYVPGGTAAYPSSVLMNAIPAKIAGVENIIMVTPP-QKNG-LNQAVLAAAKIAGVDRIYQVG 184 Leuconostoc mes...
P00815       544 GAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQndTqaLCSIDMPAGPSEVLVIADEDADVDFVASDLLSQAEHGI 623 Saccharomyces c...
P73058       190 GVQALAAIAYGTKTVSKVDKLIGPCSIYGAAAKRLLS--G--IVDVGLPAGPSESIVLADETTDPKLAALDLLIEAEHGS 265 Synechocystis s...
Q483H8       193 GAQGIAAVAYGTNTVPKCDKVVGPGSPFVVAAKKLLA--D--IIHPGTPAGPSEAIVLADDTANPKLAALDLLVEAEHGP 268 Colwellia psych...
Q9X0D1       184 GAHAVAALTYGTETVKPVDKIVGPGGVFVTLAKKHVY--G--DVGIDSIAGPSEIAIVTDGSADLDLIAADFLSQAEHDE 259 Thermotoga mari...
Q3ZXL7       196 GAQAVAALAFGTKSIPKVDKICGPGNIFVTLAKKAVF--G--VVDIDGLQGPSEVLIVADQYANAEYCASDILAQAEHDA 271 Dehalococcoides...
Q5JFR5       158 GVGAIAAMAYGV-GMRRVDKIFGPGNRFVNEAKRQVF--G--IVGIDSLAGPSEIAVIADESADKDYVLADLLSQLEHGK 232 Thermococcus ko...
Q4A044       175 GAQSIAALAYGTETLPKVDKIVGPGNQFVAYAKKYLF--G--QVGIDQIAGPSEIALIIDDSADLDAIAYDVFAQAEHDE 250 Staphylococcus ...
O33775       174 GAQAIAALAFGTESVKKVYKIVGPGNVYVQAAKYLVS--S--VVGIDGIEGPTELVIIADETAKAEYVALDMKAQAEHGP 249 Sulfolobus solf...
Q8ZY17       153 GPHGLAYAVFHM----GVDVVAGPGGLYVQAAKYILS--Q--YVGIDGIEGPTELVIYAEG-VPPEVAVRGALAQLEHGP 223 Pyrobaculum aer...
WP_011680218 185 GAQAIAALAYGTESIPQVDKITGPGNAYVATAKRDVY--G--QVDIDMIAGPSEIGILADDSASAKDVAADLLSQAEHDV 260 Leuconostoc mes...
P00815       624 DSQVILVGVnlSEKKIQEIQDAVHNQALQLP--R-VDIVRKCIA--HSTIVLCDGYEEALEMSNQYAPEHLILQIANAND 698 Saccharomyces c...
P73058       266 DSAALLVTH--SASLAEKALGYLGEYLEKLPpwR-KKFCEDGLGs-YGGILLTDSLQASLDFINDYAPEHLQVLTADPLK 341 Synechocystis s...
Q483H8       269 DSSAFLVTN--SKELAEQAQVAINEYWQHMDrlR-VDFSSTVLSgdNGGIVLTSTFEEAVDFCNDYAAEHLLILSKSPFD 345 Colwellia psych...
Q9X0D1       260 NAMSVVITT--SKEVFEKLPQVIERHLEALPeeR-RKTARISTEn-FGTIILTDSLKRAFEISNLIAPEHLEVLVENPFE 335 Thermotoga mari...
Q3ZXL7       272 LASSILITT--SEDLANRVNDIVESKADTCS--R-RDIIKQSLRd-NGLIAVVDNINEAIKLANMYAAEHLCLLVKDSEK 345 Dehalococcoides...
Q5JFR5       233 DSKAWLLTT--SRELADYCSRE------------------------GIEVLLCRNLEECAEKANEIAPEHLEIITENPEE 286 Thermococcus ko...
Q4A044       251 LARTFVISE--DEALLKQLEQKIQHILPQIE--R-QSIVQASLNd-NHFLIHVNNFSEACDLMNQIAPEHASIQTVSPHD 324 Staphylococcus ...
O33775       250 DTYIVLLSN--DDELIRRVEEKIKNDKKIY------------------YIIKTKNLDEAIEIANKIAPEHLSLYVKDAYT 309 Sulfolobus solf...
Q8ZY17       224 TSFAYLLSP--DGELLKKAEELYVRE-------RtSSMGPLKVKk-------VGGIDEAVSFIDEIAPEHLEVWGR--RE 285 Pyrobaculum aer...
WP_011680218 261 NARAILITN--SEKLATAVSKEVEDQLKVLP--R-EAIARQAIEn-NGFIYLVDTIDLMIDLMNAVAPEHLEIQLENAYD 334 Leuconostoc mes...
P00815       699 YVKLVDNAGSVFVGAYTPESCGDYSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLD 778 Saccharomyces c...
P73058       342 LVGKIDNAGEILLGNYTPSSAATYAIGVNAVLPTGGFARSYSAVSVFDFLKRSTLAYLTEEGFAGVKETVTTLADYEDFP 421 Synechocystis s...
Q483H8       346 HLGKIINAGEILLGENTPISIANYTLGPNAVLPTSMAAKTASPLSVFDYLKSCSIGYLTREGYEELAPHTYRFAKYEGFD 425 Colwellia psych...
Q9X0D1       336 PLGHIKNAGSVFLGKYTCESVGDYGAGPNHVLPTFRSARFSSGLRVSDFTKKIFITHLSEEDFRRKSELYSKMARWEGFE 415 Thermotoga mari...
Q3ZXL7       346 YLTQINHAGCIFYGEKASVVMGDYVAGPSHALPTSGTARFSSPLNILDFVKYIDIVKVDKQDIAKLGQAAATIAKAEGLE 425 Dehalococcoides...
Q5JFR5       287 LVDLIENAGAIYLGPYTPVPAADYFLGVNHVLPTGGAARFSGVLTVMDFMKPITLARVSREEFLAYRRLGMRLAEIEGME 366 Thermococcus ko...
Q4A044       325 YLNHVRYVGALFLGYYSPEVIGDYVAGPSHVLPTNQTARFTNGLSVNDFLTRHSVIDLSKDTFDTVELTARKLAHVEQLY 404 Staphylococcus ...
O33775       310 LMDKIVNAGAISLGN-TPPAIIDYVAGPNHILPTNGWAKIRGGITVYDFIKPTMYANV-RDINKQLLEASISLANYEGFI 387 Sulfolobus solf...
Q8ZY17       286 VAYRVRNVGAVSVN--MPSPYLDYVAGISHVLPTGGTARWRGVITPLAFMKPIGIAEA--VGELTLREAARKLAEYEGFK 361 Pyrobaculum aer...
WP_011680218 335 YISKIKNAGSVFLGKYASEPLGDYLAGPNHILPTGGTARFSSPLGVWDFQKRIQYLQYSAEALLADSADVTVLAREEGLE 414 Leuconostoc mes...
P00815       779 GHRNAVKI-R 787 Saccharomyces cerevisiae S288c
P73058       422 AHALAIRE-R 430 Synechocystis sp. PCC 6803 substr. Kazusa
Q483H8       426 AHANAVSHlR 435 Colwellia psychrerythraea 34H
Q9X0D1       416 AHARAIDV-R 424 Thermotoga maritima MSB8
Q3ZXL7       426 CHAEAVLK-R 434 Dehalococcoides mccartyi CBDB1
Q5JFR5       367 AHRRSLEV-R 375 Thermococcus kodakarensis KOD1
Q4A044       405 NHEQSIEI-R 413 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
O33775       388 IHGKSIGA-R 396 Sulfolobus solfataricus P2
Q8ZY17       362 YHGEAL---R 368 Pyrobaculum aerophilum str. IM2
WP_011680218 415 AHARAIES-R 423 Leuconostoc mesenteroides
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