Conserved Protein Domain Family
leuS

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PRK00390: leuS (this model, PSSM-Id:234743 is obsolete)
leucyl-tRNA synthetase; Validated
Statistics
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PSSM-Id: 234743
Aligned: 989 rows
Threshold Bit Score: 900.216
Created: 9-Dec-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
86742580    54 RYDARLAADIERRWQRRWADEGTFNSpnpVGPLS-TgfekvagrePFYIMDMFPYPSGsGLHVGHPLGYIGTDVFARYLR 132 
78357482     1 --MKYNPQAIEEKWQHIWEEKEMFRS---E-HGS-Dk-------pKYYVLEMFPYPSG-NIHMGHVRNYSIGDVVARFKR 65  
220904888    2 TQERYNPQAIEEKWQARWQAENAFAC---S-HES-Nk-------pKYYVLEMFPYPSG-NIHMGHVRNYSIGDVVARNKR 68  
242278126    2 GFGKYEPELIENKWQKEWTEKGAFNV---E-ADE-Sr-------pKYYVLEMFPYPSG-KIHMGHVRNYSIGDVVARYKR 68  
46579607     1 --MKYDHQSIETRWQKKWEDSGIFQC---D-TEA-Dk-------pKYYVLEMFPYPSG-NIHMGHVRNYSIGDVVARFKR 65  
218888174    1 --MKYDHQSIEIKWQRTWEESGAFHC---DHHSDkP---------KYYVLEMFPYPSG-NIHMGHVRNYSIGDVVARFKR 65  
120602905    1 --MKYDHQSIETRWQKKWEDSGIFQC---DTEADkP---------KYYVLEMFPYPSG-NIHMGHVRNYSIGDVVARFKR 65  
256827875    1 -MRHYDFKQIEEKWQQAWEEKACFRT---D-MSR-Dg-------eKYYVLEMFPYPSG-RIHMGHVRNYSIGDVVARYKR 66  
85858024     1 MNRKYVPQEIEEKWQRYWEEKNTFKV---TEDPSkK---------KYYLLEMFPYPSG-KIHIGHVRNYTIGDVVARYKR 67  
218779046    1 MDERYDPKKIEGKWQAHWDAAGLFKV---KEDPSkE---------KYFLMEMFPYPSG-KIHMGHVRNYSIGDVVARFKR 67  
86742580   133 MSGRHVLHPFGYDSFGLPAEQYAINTGQHPRDTTNANIANMRRQLSRLGLGHDTRREIATTDVGYYRWTQWIFQQIFNSw 212 
78357482    66 MQGFNVLHPMGWDAFGLPAENAAIKHDTHPAKWTYSNIDNMRSQLKRLGYSYDWRRELATCDAEYYRWEQLFFLKFMEK- 144 
220904888   69 MQGYNVLHPMGWDAFGLPAENAAIKNNTHPAEWTYANIRTMRAQLKRLGYSYDWSREIATCRPEYYQWEQMFFLRLLKK- 147 
242278126   69 MKGFNVLHPMGWDAFGLPAENAAIKHNTHPAEWTYANIDDMRTQLKRLGYSYDWRRELATCHPGYYKWEQQFFLKFLEK- 147 
46579607    66 MQGFNVLHPMGWDAFGLPAENAAIKNGTHPAKWTFANIDNMRSQLKRLGYSYDWQREVATCTPEYYRWEQLFFLRFLEK- 144 
218888174   66 MQGFNVLHPMGWDAFGLPAENAAIKHGTHPAKWTFSNIDNMRTQLRRLGYSYDWRRELATCTPEYYRWEQQFFLRFFEK- 144 
120602905   66 MQGFNVLHPMGWDAFGLPAENAAIKNGTHPAKWTFANIDNMRSQLKRLGYSYDWQREVATCTPEYYRWEQLFFLRFLEK- 144 
256827875   67 MQGFNVFHPMGWDAFGLPAENAAIKNNTHPAKWTYENIAYMRAQLKRLGYSYDWDREIATCHPGYYRFEQEFFLKFLEK- 145 
85858024    68 MEGYNVLHPMGWDSFGMPAENAAIERGIHPSLWTNENITHMRKQLKRMGFSYDWDREVSTCEPVYYRWEQLFFLWMYEK- 146 
218779046   68 MQGFNVLHPMGWDAFGMPAENAAIKNNTHPAKWTYENIAAMGAQLKAMGFSYDWDREIATCKPDYYRWEQWLFVQMFKK- 146 
86742580   213 ydpqagrarpiaelieefaagtrapvagpaggntavsvdavraanpaglawteldevsrrkvvnahRLAYISEQLVNWCP 292 
78357482   145 ------------------------------------------------------------------GLIYRKKAPQNWCP 158 
220904888  148 ------------------------------------------------------------------GLVYRKKAPQNWCP 161 
242278126  148 ------------------------------------------------------------------GLVYRKKSPVNWCE 161 
46579607   145 ------------------------------------------------------------------GLVYRKKAAQNWCP 158 
218888174  145 ------------------------------------------------------------------GLVYRKQAPQNWCP 158 
120602905  145 ------------------------------------------------------------------GLVYRKKAAQNWCP 158 
256827875  146 ------------------------------------------------------------------GLVYRKNAPVNWCP 159 
85858024   147 ------------------------------------------------------------------GLAYKKTSSVNWCP 160 
218779046  147 ------------------------------------------------------------------GMVYRKEASVNWCH 160 
86742580   293 GLGTVLANEEVTaDGRSDIGNYPVFRRPLKQWILRITAYAERLISDLDLV--DWPDSIKQMQRNWISPSEGASVEFtvva 370 
78357482   159 KCNTVLANEQVI-DGLCWRCDSVVEQRDLAQWFLRITSYAEELLADLEKLtgGWPDRVLTMQHNWIGKSVGAEIEFavdg 237 
220904888  162 SCHTVLANEQVI-DGLCWRCDSRVVQKDLTQWFLKITAYGDELLRDLGTLegGWPERVIAMQRNWIGKSTGAAITFglek 240 
242278126  162 TCHTVLANEQVE-EGLCWRCDTEVIQKELSQWFMRITDYAEELLESLGELegGWPERVITMQRNWIGKSIGAELDFeven 240 
46579607   159 KCHTVLANEQVI-EGLCWRCDSAVEQKELTQWFLRITDYAEELLADLSKLenGWPERVLSMQRNWIGKSTGAEIRFaldg 237 
218888174  159 KCHTVLANEQVI-EGLCWRCDSAVEQKNLTQWFLRITDYAEELLADLDKLeaGWPERVVSMQRNWIGKSIGAEIVFpleg 237 
120602905  159 KCHTVLANEQVI-EGLCWRCDSAVEQKELTQWFLRITDYAEELLADLSKLenGWPERVLSMQRNWIGKSTGAEIRFaldg 237 
256827875  160 SCHTVLANEQVE-EGLCWRCDSEVQQKQLSQWFLRITDYAEELLADLDKLtdGWPERVLTMQRNWIGKSIGAEISFkvkd 238 
85858024   161 RCQTVLANEQVE-AGLCWRCGSEVVEKILDQWFFRITAYIDELLAGCDRLt-GWPERVLTMQRNWIGKSYGCEVSFpmad 238 
218779046  161 TCQTVLANEQVE-QNMCWRCGDEVEQKKLKQWFFRITDYADDLLEHCDKLp-GWPEKVVTMQKNWIGKSHGAEILFsvkd 238 
86742580   371 pgeeagasdpsgsstarrIEVYTTRPDTLAGATFLVLAPEHPLADALiadtwpadtpvswrfpagrpgggtepadtagPE 450 
78357482   238 --------------sdetVKVFTTRPDTVFGSTFMSIAPEHPLVEKLit----------------------------gTG 275 
220904888  241 nv-----------egvkgIDVFTTRPDTVFGVTFMTLAPEHPLVEHLie----------------------------gYE 281 
242278126  241 --------------sdetISVFTTRPDTLFGATFMSLAAEHPMVEKLie----------------------------gKP 278 
46579607   238 --------------rddsITVFTTRPDTIFGATFMSIAPEHPLVEELid----------------------------gKP 275 
218888174  238 pgg---------sgnddsITVFTTRQDTVFGATFMSLAPEHPLVEQLid----------------------------gKP 280 
120602905  238 --------------rddsITVFTTRPDTIFGATFMSIAPEHPLVEELid----------------------------gKP 275 
256827875  239 --------------ldeaIPVFTTRPDTLFGATFMSLAPEHPLVEKLva----------------------------gTA 276 
85858024   239 --------------gngdIKVFTTRQDTLFGATFMLIAAEHPLVMELik----------------------------gKP 276 
218779046  239 --------------sdvkIKVFTTRPDTLCGATFMCLAPEHPLVEDLsk----------------------------gTA 276 
86742580   451 agadpawtPRAAVDAYREFAAHRSDRQRgeevIDRTGVFTGSYVRNPVGGGVIPVFLADYVLLGYGTGAIMAVPAHDSRD 530 
78357482   276 --------QEETVRAFVTRIRNMDRIERtadtLEKEGVFTGAYCINPLSGRRMPIYVANFVLAEYGTGAVMAVPAHDERD 347 
220904888  282 --------KADEVRAFVERIRNMDRLDRqsdlLEKEGIFTGAYALHPFTGQRVPLWLGNFVLADYGTGAVMGVPAHDQRD 353 
242278126  279 --------EADKVREFVHKVSNMDRIVRgaddLEKEGVFTGAYCINPLNGQKMPIYVANFVLMGYGTGAVMAVPAHDQRD 350 
46579607   276 --------QADDVRAFVERIRNMDRIDRqsdtLEKEGVFTGAYCVNPFTGRKMPIWVANFVLAEYGTGAVMAVPAHDQRD 347 
218888174  281 --------EAPAVRAFVERIRNMDRIVRqsddLEKEGVFTGAYCVNPFTGRRMPIWVANFVLAEYGTGAVMAVPAHDQRD 352 
120602905  276 --------QADDVRAFVERIRNMDRIDRqsdtLEKEGVFTGAYCVNPFTGRKMPIWVANFVLAEYGTGAVMAVPAHDQRD 347 
256827875  277 --------QEAAVGEFVDRIAKMDRIVRtaddLEKEGVFTGQYCINPLTGREMPIYVANFVLMGYGTGAVMAVPAHDQRD 348 
85858024   277 --------VEKDARTFAEEVKKQDKLMRtsdyYEKQGLFLDCYCLNPLTGWEMPIFATNFVLADYGTGCVMAVPTHDQRD 348 
218779046  277 --------QEAVVQEFVARMAKQDKAKRtaddKEKEGVPIGAQCINPLTGKTMEIYTANFALMEYGTGAVMSVPTHDQRD 348 
86742580   531 FSFARAFDLPIPAVLepdadwyaahgvvpatpsaqwpeaFSGAGEYRPGPasapVLVGLSKSEAIKATVHWLEEIGAGRS 610 
78357482   348 FEFARKYDLPMEVVIqpegaelt---------patmetaYTGQGTMVGSG----QFSGLPNEEGKTKIAEWLEANGKGKR 414 
220904888  354 FEFAHKYSLPVQVVIcpegqelt---------petmpeaYTGEGVMVNSG----QFDGMLNEDGKKAVAQSLEKNGKGKA 420 
242278126  351 FEFAKKYDLPKQVVIqpegetln---------vaemeeaYTAPGVLVNSG----EFDGMPNEDAKGAIVDFLGKSGKGKK 417 
46579607   348 FEFARKYDLPMQVVIqpqgeald---------patmsaaWTEAGALVNSG----AFDGLANEDAKQRIADDLETTGNGRR 414 
218888174  353 FEFARKYDLPMQVVIqpegdald---------taamqaaWTEAGLLVNSG----EFDGLPNEAAKQKIADSLETSGKGRR 419 
120602905  348 FEFARKYDLPMQVVIqpqgetld---------patmsaaWTEAGALVNSG----NFDGLANEDAKQRIADDLETTGNGRR 414 
256827875  349 FEFAAKYDLPKQIVImpregald---------latmteaFTDPGVMANSG----EFDGMDSEAAKKAIIDHLAAGGLGKP 415 
85858024   349 FEFAEKFGLRKVVVIsppdktld---------petmteaYVEEGILVNSG----PFNGMENLKALDAIADHLIALGRGKR 415 
218779046  349 FEFATKYGLEKIVVIqpegeals---------petmteaYTDPGVLVNSG----QFDGMKNTDAMEAIAQYLDENDMGKK 415 
86742580   611 ARSYRLRDWLFSRQRYWGEPFPIVFDVD-GlPHAVPDELLPIELPemtdfRPTAMAEddasdpvPPLARVADWVTVTLDl 689 
78357482   415 TVNYRLRDWNISRQRYWGAPIPVVYCEKcG-IVPEKAENLPVRLP-----LDIKTRSdg----rSPLGETPEFYECRCPa 484 
220904888  421 TTQFRLRDWNISRQRYWGAPIPVIYCDKcG-AVPEKEENLPVLLP-----LDVKTRSdg----rSPLADTPSFAQCICPq 490 
242278126  418 SINYRLRDWNISRQRFWGSPIPVIYCDEcG-IVPVPEQDLPVVLP-----EDAVMNEdg----rSPLPDMESFHKVTCPk 487 
46579607   415 TINYRLRDWNISRQRYWGAPIPVIYCDAcG-VVPEKEENLPVVLP-----LDVKTHDdg----rSPLPHTPAFYECTCPv 484 
218888174  420 TVNYRLRDWNISRQRYWGAPIPVVYCDAcG-VVAEKDENLPVLLP-----LEVRTHEdg----rSPLPDTPEFAECACPk 489 
120602905  415 TINYRLRDWNISRQRYWGAPIPVIYCDAcG-VVPEKEENLPVVLP-----LDVKTHDdg----rSPLPHTPAFYECTCPv 484 
256827875  416 TVNYRLRDWNISRQRYWGAPIPVIYCDDcG-IVPVPASQLPVELP-----LDVKVNAdg----rSPLPGCESFVNVPCPt 485 
85858024   416 TIQYRLRDWGISRQRYWGAPIPMIMCPKcG-TVPVPEAELPVVLP-----RDVDFSGeg----gSPLAKHPEFLNTTCPs 485 
218779046  416 TVQYRIRDWGISRQRYWGAPIPMIHCPDcG-ITPVPEDQLPVILP-----EDANLLEgg----kSPLPELDSFVKTTCPq 485 
86742580   690 gdGP-KQYRRETNTMPQWAGSCWYYLRYLDPTn--TERFVDPTVERYWMArpgavpgdggVDLYVGGVEHAVLHLLYARF 766 
78357482   485 --CG-EKARRETDTMDTFVESSWYFARYTSAGd--NEAPFDAQALKYWLP----------VDQYIGGVEHAILHLLYARF 549 
220904888  491 --CG-GPARRETDTMDTFVESSWYFARFASARd--TETPFDMDAVKYWLP----------VDQYIGGVEHAILHLLYSRF 555 
242278126  488 --CG-KMAQRETDTMDTFVESSWYFMRYTDSRk--ADAPFDSKSLEYWTP----------VDQYIGGIEHAILHLLYARF 552 
46579607   485 --CG-GKARRETDTMDTFVESSWYFARYTDATn--DKAPFTPDALRYWLP----------VDQYIGGVEHAILHLLYSRF 549 
218888174  490 --CG-GKARRETDTMDTFVESSWYFARYTSASk--DDGAFDPAALKYWMP----------VDQYIGGVEHAILHLLYSRF 554 
120602905  485 --CG-GKARRETDTMDTFVESSWYFARYTDATn--DKAPFTPDALRYWLP----------VDQYIGGVEHAILHLLYSRF 549 
256827875  486 --CG-KPARRETDTMDTFVESSWYFARYTSARn--ETTAFDPAEVAYWMP----------VDQYIGGIEHAILHLLYSRF 550 
85858024   486 --CG-GPAKRESDTMDTFVESSWYFERYCCPHfaeKPGLN-RQQVDYWMP----------VDQYIGGIEHAILHLLYARF 551 
218779046  486 --CGnENARRETDTMDTFVESSWYPERYCSPKc--DDGMFDVDAVKYWMP----------VDQYIGGVEHAVMHLLYSRY 551 
86742580   767 WHKVLYDLGHV--STKEPFKRLFNQGYIqadaftdargmyvpaaevt--atpdgrflfqgapvnrrsgKMGKSLKNSVSP 842 
78357482   550 FIKALRDCGYM--DLDEPFANLLTQGMVlmd-----------------------------------gaKMSKSKGNVVDP 592 
220904888  556 FTKVLRDMGFFppELSEPFNNLLTQGMVlkd-----------------------------------ggKMSKSKGNVVDP 600 
242278126  553 FTKILRDEGYT--ELSEPFKNLLTQGMVlkd-----------------------------------gaKMSKSKGNVVDP 595 
46579607   550 FTKALRDCGFI--ELDEPFANLLTQGMVlmd-----------------------------------gsKMSKSKGNVVDP 592 
218888174  555 FVKALRDCGYM--DLDEPFANLLTQGMVlke-----------------------------------gaKMSKSKGNVVDP 597 
120602905  550 FTKALRDCGFI--ELDEPFANLLTQGMVlmd-----------------------------------gsKMSKSKGNVVDP 592 
256827875  551 FVKALRDEGYL--THDEPFKNLLTQGMVllh-----------------------------------gsKMSKSKGNVVDP 593 
85858024   552 YTRMLRDFGLV--GVDEPFTNLLTQGMVckettrcpdhgylypeev----regrcihclaevivgkteKMSKSLKNVVDP 625 
218779046  552 FTRVLNDFGLV--DFKEPFTRLLTQGMVcketlkcpehgwlfphevegsgdertctkcgkiveagrveKMSKSKLNVVDP 629 
86742580   843 DEMYDRFGADTLRVYEMAMGPLDADRPWHTDDIVGSHRFLQRLWRTVVD----------ETTGAAAVVDEPLDd-----E 907 
78357482   593 TEMISRYGADTVRLFCLFAAPPERDFDWSDSGIEGASRFVNRVWRLVEDlpagmapmapCSSSSDDCTGAAAK------D 666 
220904888  601 TEMIKKYGADTVRLFCLFAAPAERDFDWSDSGIEGASRFINRVWRLFVEeqar---llpLKACASTAQDAQSPea---rD 674 
242278126  596 NAMINKYGADATRLFILFASPPEKDLEWSDQGLEGAHRFLNRIWRLAEEfeg----klsATGACAKPSMELSSda---kK 668 
46579607   593 TEMIARYGADTVRLFCLFAAPPERDFDWSESGIEGSYRFVGRVWRLVEElreh---llaVGACSSTAEDAKTPva---rE 666 
218888174  598 TEMIARYGADTVRLFCLFAAPPERDFDWSDSGIEGSYRFIGRIWRLAEElsgv---llpVKACSATAADAATPqg---kD 671 
120602905  593 TEMIARYGADTVRLFCLFAAPPERDFDWSESGIEGSYRFVGRVWRLVEElreh---llaVGACSSTAEDAKTPva---rE 666 
256827875  594 DEMIAKYGADTVRLFCLFAAPPEKDLEWNDKGIEGASRFLNRLWRLVDEldd----vlsPVGTCVSVEGTLGEse---aE 666 
85858024   626 DYLVRQYGADTARMFCLFAAPPEKDLEWSDQGVEGSFRFIGRTWRIVVDyldd--lqgiAPFAGDGELEGELK------S 697 
218779046  630 EELLAKYGADTIRLFCLFAAPPERDLDWSEEGVEGSYRFLQRVWRMFAAhm-------dEVKDAQPFEGSPDDldgylkD 702 
86742580   908 ALRVLHRTILTVTAEYAG-LRFNTAVARLIELTNFVSKs-------YGKSPTPRALAEPLTLMAAPLAPHIAEELWSRLG 979 
78357482   667 IRQKEHATVKKAGADIQNrFQFNTAISAVMELVNALYLtrdelgadEKGRRVLGSAVSSVLAMLAPITPHLCEELWEQLG 746 
220904888  675 LRRREHLTVKKAGEDMGDrFQFNTAIAAVMELVNTMYIsrekmgstEGDRRVFSSAMATVLTLLSPIIPHVCEELWNRLG 754 
242278126  669 LRLKEHETVKRASRDMENkFQFNTVIAASMELVNEIYSlkdklmetEDGRFALSSAYSTVLTVLSPIAPHICEELWAAMG 748 
46579607   667 LRLKEHATVRKAGDDLNDrFQFNTAIAAVMELVNALYLakdelvadESGRKVLSSAVSTVLTLLSPFTPHLSEELWALLG 746 
218888174  672 LRNKEHATVRKAGADISDrFQFNTAIAAVMELVNALYLakdelsgdEGGRKVLSSAVATVLTLLSPITPHIAEELWASIG 751 
120602905  667 LRLKEHATVRKAGDDLNDrFQFNTAIAAVMELVNALYLakdelvadESGRKVLSSAVSTVLTLLSPFTPHLSEELWALLG 746 
256827875  667 LRRKEHDTVRRVERDIENkFQFNTAIAAMMELVNSLYAtkddlrasKNGPRLLSSAISSLLVTLSPIAPHVCEEVWDRMG 746 
85858024   698 LRRKTHQTIRKVRDDMGErFHFNTAISAIMELVNTLYGlprppredRTALAVIRETIEAIILLLAPIVPHLTEELWQMLG 777 
218779046  703 LYKKTHQTIKKVTEDIDGrFHFNTAISAVMELVNMVYGlddn-lqgEKRAGVLRAAVEAVILLISPMTPHFTEELWSLFG 781 
86742580   980 H-EESVSTVAFPIGDPALAAESVRTIPVQVNGKVRFTIEVPDGSAEQTVRDLLAAHPEFARQTDGRTIKKIIVVPGRIVN 1058
78357482   747 H-KDMLTARPWPRYDEDALLRDEVVIPVSVNGKLRSKMTVPAGTGKEELEKLALAEANVVRHTEGLTVRKVIVIPGKMVN 825 
220904888  755 H-DASLSDEPWPQWDKEATAQDTVTVALQVNGKLRGTVDIPAGADKAAMEEAALADSSVQRHTAGLTVRKVVVVPGKLVN 833 
242278126  749 Y-EGYIAEVEWPEHDEAALVTDEILIIIQVNGKMRGKLSVPAAASKEEIEETALAHENVTKHTDGKTIRKVIVVPGKLIN 827 
46579607   747 H-TESVSTLPWPRWKEDALVRDTVTLVVQVNGKLRGKLDIPADASREEVETLALNEPNVLRYLEGVTVRKVVVIPGKLVN 825 
218888174  752 N-AGRITDEPWPQWSEEALARDEETIVVQINGKLRGRVSVPAGADAKAIEAAALSEPNVARHLEDVTVRKVVVIPGKLVN 830 
120602905  747 H-TESVSTLPWPRWKEDALVRDTVTLVVQVNGKLRGKLDIPADASREEVETLALNEPNVLRYLEGVTVRKVVVIPGKLVN 825 
256827875  747 Y-TRTLAAEPWPAHDPEALRTSEVTVVLQVNGKLRSQITVAADATSEEIETQAMNDQNVSRHIEGKTIVKTIVIPGKLVN 825 
85858024   778 HqGTCLADTPLPVYDPTVAAEDEMTIVIQVNGKVRSRVIVAADEAEDKIKALAMGDEKVSRFLEGKSVIKQVYVPKKLVN 857 
218779046  782 K-TQCVLETPWPAWREDALTADEVVVVLQVNGKLRSKLNVPLDTDDEKIKEMALADEKVQKFMGGKPIRKVIVVKNKLVN 860 
86742580  1059 IAI 1061
78357482   826 VVA 828 
220904888  834 IVA 836 
242278126  828 IVA 830 
46579607   826 VVV 828 
218888174  831 VVV 833 
120602905  826 VVV 828 
256827875  826 VVV 828 
85858024   858 IVV 860 
218779046  861 VVV 863 
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