Conserved Protein Domain Family
hisS

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PRK00037: hisS (this model, PSSM-Id:234586 is obsolete)
histidyl-tRNA synthetase; Reviewed
Statistics
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PSSM-Id: 234586
Aligned: 978 rows
Threshold Bit Score: 249.68
Created: 9-Dec-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
126463989  10 PRAETPKGFRDYFGADVTERKAMLDAVAEVYHRYGFDPLETSAVETVEALGKFLPDVdrpnEGVFGWQDEDGDWLALRYD 89 
15920522    2 ISYEPVRGMKDYYGEELHKIKVVENAFLKIVKLAGYQEVETPIVEDFQLFALKGGEEl--rNTMYVFKDKaGREVALRPE 79 
18312709    7 HLRRPVRGMRDWLPPQYYALRHMEEVLCKVAESFGYRRVETPVVEHFEVLAKKAGQDv--iNEIYYFKDKaGRDLGLRFD 84 
126459143   7 HLRRPVRGMRDWLPHQYYALQQLEALLSRVAESFGYRRVETPVVEHFEVLARKAGQEi--vNEIYYFRDKAGRELGLRFD 84 
145590899   7 QLRRPVRGMRDWMPQQLYALRRMEEVLSSVAEQYGYRRVETPVVEHFEVLAKKAGQEv--iNEIYYFRDKaGRELGLRFD 84 
146305013   2 VSYEPMRGMEDYFDVDSKIIRWIESNFRETVEKAGYKEAMTPIVEDFELFSLKGGEEl--rNTMYVFKDKgEREVALRPE 79 
171185112   7 HLRRPPRGMRDWLPPQLYALIEMEERLSKVAESFGYRRVETPVVEHFEVLAKKAGQEv--vNEIYYFKDKAGRDVGLRFD 84 
229581614   2 TKFETVRGMKDYIGIDAEKIRYLESTFRDLAIKYGYSEIITPVVEEFKLFALKGGEEl--rETMYVFKDKaDRELSLRPE 79 
70606470    2 SEFEPIRGMKDYYGEELNKIKFIEETFRTVVLNSGYQEVYTPIVEDFKLFSLKSGEEi--rKTMYVFKDKADREVALRPE 79 
119873110   7 YLRRPPRGMRDWLPPQFYALRHMEETLSKVAEAFGYRRVETPVVEHFEVLAKKAGQEv--vNEIYYFKDKAGRDLGLRFD 84 
126463989  90 LTAPLARVAAQFRndlpsPYRRYAMGPVWRNEKPGPGRFRQFYQCDADTVGSASVA-ADAEICAMLSDALEVVGip---- 164
15920522   80 FTPSIVRFYLNSLqhlpkPIRLYYLGTVYRYDEPQFGRYREFRQAGIELLGSSNIY-SDLEILQILIEIYRELNlinkir 158
18312709   85 MTVPVARVLSYNLel-prPVRWYYFTKVFRYDEPQHGRYREFYQFGVELVGSSSPR-ADAEVIQLLIASLEAAGa----- 157
126459143  85 MTVPIARVVSYNLdl-prPIRWYYFTKVFRYDEPQHGRYREFYQFGVELIGSASPR-ADAEVVHLLAESLAAAGa----- 157
145590899  85 MTVPIARVLSYNLdl-prPVRWYYFSKVFRYDEPQHGRYREFFQFGVELIGSASPR-ADAEVVQLLAASLEAAGa----- 157
146305013  80 ITPSIVRLYLNSLqhypkPLRIFYIGRVYRYDEPQQGRYREFRQAGVELLGSDSIL-ADIEVLHLLENFYRRINlkdkis 158
171185112  85 MTVPVARVISYNLdl-prPVRWYYFTKVFRYDEPQHGRYREFHQFGIELVGSASPR-ADAEVIQVFIEALEAAGa----- 157
229581614  80 ITPSVARAYIQNLqsspkPIRLFYFGTVYRYDEPQYGRYREFRQAGIEMIGDSSIL-ADLEVLDLLYNFYDKLNlsndit 158
70606470   80 ITPSIVRVYLNSMqhlpkPLRLFYVGQVYRYDEPQFGRYREFRQAGVELLGSS-SSfADIEVISLLNEIYDSLGlkdkii 158
119873110  85 MTVPIARVISYNLsl-prPIRWYYFTKVFRYDEPQHGRYREFYQFGIELIGSASPR-ADAEVLQVFTQALDAVGarsyiv 162
126463989 165 --------------rgDYIVRVNNRKVLNGVMEVaGVLD-PSDp--aKF--------------EAERGIVLRA--IDKID 211
15920522  159 lkin--nislirkilnKLNISDNLQEHFLHLIDKgKIDEaLSLlpssEY--------------TELITNILSVnnLDISS 222
18312709  158 ---------------sNFYVRINDRRAVDKLLEHlGVAP-YRDiiyka----------ldkklKLPREDVIKI--MTGGG 209
126459143 158 ---------------sNYVIKLNDRRVVDKLLEG------MGL--------------------AAYKDVVYKA--LDKRY 194
145590899 158 ---------------sKYVIRINDRRAVDKLLES------LGAlshrDAv-------------YRALDKKLKL----PRE 199
146305013 159 lkinnigifriifnklSFDEQVQE--HLLHLLDKgKIEE-AEKi--lDEki----------rdNSKIRQFIYT--LITNG 221
171185112 158 ---------------rDYVVKINDRRAVDKLLESlGVLQ-HRDviyr-------------aldKKYKLPREQV--VDIMT 206
229581614 159 i-------------------kinnigIFRKIMDKyNIED-------------------------NLQEHILHL--IDKNK 192
70606470  159 ikin--nigiyreifnKAGITEEQQEHLLHLIDKgKVDDaLKEf--tDNnykdlitylislkfDKLESDKLES--LRREV 232
119873110 163 kindrrvvdkllerlgVSAYRDVIYRALDKKLKLsREEV-IKLm--aEG--------------GVSLDTAERI--YDIAE 223
126463989 212 RlgetgvrallgsgrkdesgdfTk-----------------gAGLSDDqaA------------IIMSFvnaprainermn 262
15920522  223 Ynki------------------------------------keDLTEKYnlK------------DLI-------------- 240
18312709  210 V---------------------Skei--------------aeEIYNTAteI------------TIQEAvel--------- 233
126459143 195 Kap-----------------reEvvgimtrggvppskaeelyEKATEMplQ------------EAVDFvt---------- 235
145590899 200 Ev---------------------------------------iGIMTSGglPrdaaekiydtasEMS-------------- 226
146305013 222 R---------------------Sl-----------------kLE------E------------AMREA------------ 233
171185112 207 Nggvpidk-------aeriydaSe-----------------eMTLEEAvdA------------VLR-------------- 236
229581614 193 Inea------------------------------------ldILEKNLknK------------DIIDFfykiltkkdt-- 222
70606470  233 S---------------------Kynf-------------nleGEINKL------------------SF------------ 248
119873110 224 E-----------------------------------------MSIEEA--V------------NVITK------------ 236
126463989 263 dfseflsvdsetleahpeartavsiarawtsqspseqpsknrltslaaigilgdlvkgssQGqd------gvSELAQ--- 333
15920522  241 ------------------------------------------------------------------------QDLDRim- 247
18312709  234 ---------------------------------------------------------lykLDka------lgASYEK--- 247
126459143 236 -----------------------------------------------------------rIDke------lgGFYAA--- 247
145590899 227 ------------------------------------------------------------LDeav----evlRRLDGrlg 242
146305013 234 ------------------------------------------------------------EKtelselvneiENLKL--- 250
171185112 237 ------------------------------------------------------------LDag------lgSFYQK--- 247
229581614 223 --------------------------------------------------kledieslaeLEev------srLDIKSefl 246
70606470      --------------------------------------------------------------------------------    
119873110 237 ------------------------------------------------------------LDsg------lgSFYNK--- 247
126463989 334 -----IADYLEA---QGygpdRIV-VDPSVVRGLGYYTGPVFEAELtfeifDEKgRKrqF---GSVAGGGRYDdLVKRFT 401
15920522  248 ----lLKNILDN---LGv---NSY-IDLGFVRGLAYYTGLIFEVLH-------------PsvsFSIAGGGRYDnLVELYG 303
18312709  248 -----IVKYLE----ASvp-mERLkFDMSIVRGLDYYTGIVFEAFV-----GEY-----K---LAVGGGGRYDdLLELYS 304
126459143 248 -----FVKYLEA---AVg--lERLiFDLSIVRGLDYYTGVVFEAFA---------GEykL----AVGGGGRYDdLLQLYS 304
145590899 243 eayakFVKYLEA---AVpl-eRFK-FDMSIVRGLDYYTGVVFEAFV-------------GdywLAVGGGGRYDdLLELYS 304
146305013 251 -----ISEILSS---LNl---DHI-VDLGFVRGLAYYTGPIFEVVK-----RDL-PF-------SIAGGGRYDsLVEVYG 305
171185112 248 -----LVGYLAT---AVp--vDRLrFDMSIVRGLDYYTGVVFEAYV-----GKY-----R---LAVGGGGRYDdLLELYS 304
229581614 247 y-lfrLSRILSD---LNi---KFK-IDLGFVRGLAYYTGLIFEVLH-----PSV-----Q---FSIAGGGRYDkLIELYG 305
70606470  249 -----ISEVLED---LGv---KIK-IDLGFVRGLAYYTGVIFEVIH-----PDV-----S---FSIAGGGRYDnLVRLYG 303
119873110 248 -----LLKYLEAavsLD----KFR-FDMSIVRGLDYYTGMVFEAFA-----GEY-----K---LAVGGGGRYDdLLELYS 304
126463989 402 GQSVPATGVSIGVDRL--LAALRAKGragaeaQGPVVVTVMd-rDRMGD--YMAMVGELRr-A--------GL--RAEL- 464
15920522  304 GPQTPAIGFAIGVERT--ALVLEEPNtvk-ekQNKIGVIVLs---dEAIlyAIRIVDKLRsnNyiatinlkSI------- 370
18312709  305 GVKTPALGFAIGVERL--MEAVGIQNve---rPLDYYIYIFd---dDAYkyAAAVAKKLRte-------gySV--VVELg 367
126459143 305 GVKTPALGFAIGVERLmeAVGLQAVEk-----PLDYYIYIFd-eSAYQT--AIYIARELRrk-------gySA--VVELg 367
145590899 305 GVKIPALGFAIGVERLmeAVGLQSVEk-----PLDYYIYIFd---dDAYkhAVALANRLR--Kq-------GH--SVVV- 364
146305013 306 GNRTPAVGFAIGIERT--MYALNKDGikf--dsnAPLVAVValdRSVIPh-ALSIVSMLR--Dk-------GF--ITVL- 368
171185112 305 GVKMPALGFAIGVERLmeAVGLERVEk-----PLDYYIYIFd-dGAYPH--AVALAKKLRa-A--------GHsvAIEL- 366
229581614 306 GLPSPAIGFAIGVERT--LLVIKDLKve---ePVNVIVIGMs---eDTIpsMFMVSRILR--Ke-------EY--KVVIn 366
70606470  304 GADTPAIGFAIGVERT--ALVINKIKsd--lqRKKIAVIPLi-sTKDSLslAIRLLNILRk-Nni-----iGVlnLKDV- 371
119873110 305 GVKMPALGFAIGVERLmeAVGLEGVEk-----PLDYYIYIFd-dDAYPY--AVAIAKRLRsa-------gySV--VVELg 367
126463989 465 --YLGNpKNFGNQLKYADARKSPVAVIQGSDEATRGVVVLKDLVLGaqiaagasleewksrpAQ--------VEVPRADL 534
15920522  371 --------SISKLIPSYAEEGYSFLIFIGKKEYEDKTITLKNLSTK----------------EQ--------VTIKEENL 418
18312709  368 --E----KGLKDAFEYALKVGARHIIIIGRKELEKGVIKVRDL-------------------EK--------------RI 408
126459143 368 --D----KGLKDAFEYVLKIGTRFLVILGKKELEKGVVKVRDLQKR----------------EE--------VEKPIDEF 417
145590899 365 --ELGE-KNLKDVFEYVLKIGTRYLVLIGRKELEKGVVKIRDLQKR----------------GE--------VEVPLSAL 417
146305013 369 --NNKE-IPLSKLVPLYAEQGFTHLIIMGQKEITSGKVTVRNLVKR----------------EQ--------ITTDVKEL 421
171185112 367 -----GeKNLKDAFEYILKVGTKYLIIMGRRELERGVVKIRDL-------------------QRreefekplAEF----- 417
229581614 367 tkD----QPLSKLLPYYASQGFKVAIIIGKQELEKNMITVRNLITR----------------KQ--------ISVPLENI 418
70606470  372 --------PLSKLMTYYVEEGYNAIVLIGKKELEENSITIKFLEKR----------------EQ--------KTVKLEKI 419
119873110 368 --E----KNLKEVFEYILKIGTRYLIIIGKKELEKGVVKIRDLQRR----------------EE--------FEKPFSEF 417
126463989 535 V--RAVQ 539
15920522  419 L--DYLK 423
18312709  409 EveKPLS 415
126459143 418 IrgA--- 421
145590899 418 L--S--- 419
146305013 422 T--NVIT 426
171185112     -------    
229581614 419 E--DAIK 423
70606470  420 E--DVLI 424
119873110 418 YgtT--- 421
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