Conserved Protein Domain Family
FKTN_N

?
pfam19737: FKTN_N 
Fukutin N-terminal
This is the N-terminal domain of fukutin, which contains the transmembrane domain required for its localization to the Golgi and participates in the interaction with POMGnT1 for normal POMGnT1 location and activity. Fukutin is a ribitol-phosphate transferase that forms a complex with FKRP and TMEM5 which may contribute to specific biosynthesis of glycans required for dystroglycan function.
Statistics
?
PSSM-Id: 466166
Aligned: 12 rows
Threshold Bit Score: 474.173
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
GCF47125       1 MQRINKNVVLGLLTLTSSVFLLFQLYYYKYYLSPKPKLLISpSLLCVSLCLILLDQHVVRKFLGLVSTYHLHVHLIDPLV 80 
XP_003223799   1 MQRINKNVVLGLLTFTSSVFLLFQLYYYKYYLSPKNGTVFP-KIKGSKTGQESSRWYVVRKFLSLVSSHNIAVHLIDPLL 79 
KYO35108      31 PGRQSLLRASEKMRAPEQSSSCHRLYYYKYYLSPKNGPAFS-RVKGSQSGQDNTRWHVVKKFLGLVSNHNVPVYLIDPLV 109
2_pfamImport   1 MPRINKTIILTLLTVISFIFLLFQLYYYKEYFSSKNGSYVS-DSKESYSMEDSVHWKVVKKFLDLASIHNIPLYLIDPLV 79 
XP_006626699   1 MPRINKSVVLALLTVTSSVFLLFQLYYYKLYLSKN-GSHYF-KVKDGLPASDAQ-WHVTKKFMELVAKHNLPVYLIDPVV 77 
XP_010885909   1 MPRINKTAVLALLTATSSIFLLFQLYYYRQHVSQN-GPHIF-GRTVHLSGKDTQ-WKVVKKFMGLVHKYNLPVFLVDTAS 77 
XP_007668829   1 MSRINKNVVLALLTLTSSVFLLFQLYYYKHYLSSKNGAGFS-KIRGSHVGQDSTQWRAVKKFLMVASSQNVPVTLIDPLV 79 
XP_016279768   1 MSKINKNVILALLTLTSSVFLLFQLYYYKHYLSPKNGAGLS-GVRGTKIGHNNAQWRVIKKFLKLASNQDMPVFLIDRSV 79 
XP_009455336   1 MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSTKNGAGLS-KSKGSRIGFDSTQWRAVKKFIMLTSNQNVPVFLIDPLI 79  chimpanzee
XP_030291745   1 MPRVNRTAVLSLLIVSSSVFLLFQLYYYRKYVSKP-GPHIL-SRTGHLTANDVQ-WQTVKKFLALAQRFRLPLFLADTAA 77  gilthead seabream
XP_021331643   1 MARLNRTFVLTLLIAVSSVFLLFQLYNYRLSAAKN-GFNVL-NNKGYLSGKEAH-WHLLKRFLGLVHKFKLPVFLVDTVS 77  zebrafish
XP_013043775   1 MQKINKNAVLALLTLSSLVFLLFQLYYYRSYLAHKNGAVFS-KVRGSQSGQDSTRWHVVRKFLSLISSHNIPVYLIDPLI 79  Anser cygnoides...
GCF47125      81 LGLIATDLEQLRASPEGSYSECRYFCAPRYFTTFALLDKTWKLEAGLFRAAERVGFQWLKVQSKDPRLEGMEDLSGTEIP 160
XP_003223799  80 LGLIDVDLEQLRISPDGSQSECKYFCAPRDCTTFALLDKAWKHEVGLFRAAERVGFQWLKIQSKDPRLEGMDDLSGTEIP 159
KYO35108     110 LGLINKDIKQLRSASDGSSPECKYFCAPRDFTTFALLDKTWKHETGLFRSAEKMGFQWLKIQNKDPRLEGMDDLSGIEIP 189
2_pfamImport  80 LGRMNENIQNENPDSRLN---CKYLCIPRGFTTFALLDKFWKNDVFLKKEAEEEGFQWMELSGKDPRLAGMGDLSGTEIP 156
XP_006626699  78 LGLLSQDAHPLKDSLSKG-KDCRYICTQREFITFALLAKFWKNDARLAHAAAEAGLEFLEVRGKDPRLAGPDDLSGMEIP 156
XP_010885909  78 LSILSQGSMLLKDSLVKE-PHCSFLCTNRDFVTFALLGNLWKYDAGLVSAAEEKGFELLEVRGKDPRLVSMDDLSGNEIP 156
XP_007668829  80 LELIHRDFERLEDSSDGKTSECKYFCAVRDVTTFAVLDKQWKNEVGWFQAAEKMGFQWVEIESKDPRLEGMDYLSGTEIP 159
XP_016279768  80 LEAINKDFEQVKNSTYGSVSECKYFCAKRDFTAFALLNHLLKNEENWFQIAERMGFQCLKIQSKDPRLDGIDYLSGTEIP 159
XP_009455336  80 LELINKNFEQVKNTSHGSTTQCKFFCVPRDFTTFALQYHLWKNEEGWFRIAENMGFQCLKIESKDPRLDGIDSLSGTEIP 159 chimpanzee
XP_030291745  78 LTLLSQDALRQRDRLVRE-PHCSFLCTGRPITSFALHANLWKYDPGLLLAAQQKGFDLLELRGEDPRLASLDTLSGEEIP 156 gilthead seabream
XP_021331643  78 LALLSQDAVLYRDSQLKD-PHCSFLCTHRDFTSFALLGNLWKYDAALLDAASERGLELLEIHGKDPRLISTDDLTAKEIP 156 zebrafish
XP_013043775  80 LGLVDKDIEQIRSSSDGPSPECKYFCVPRDFTTFALLDKTWKHEVGLFRTAEKMGFQWLKVLNKDPRLDGMDDLSGTEIP 159 Anser cygnoides...
GCF47125     161 LHYIFRLANHAVHLVAFYERNGNYLWHGQLRLKRHTDRKFVPFRKLQYGRYPGAYEKLELQSVSLDGLTVQIPKEPSRFL 240
XP_003223799 160 LHYVFKLATHSIHLVVFYERSGNYLWHGPLRLKLHADRKFVPFRKLPFGRYPGAYDKLELLSVSIDGLTVQIPKEPSVFL 239
KYO35108     190 LHYIFRLASHAIHVVVFYERSGNYLWHGQLRLKQNMDRKFVPFRKLHFGRYPGAYGKLVLLPVSIDELKVQIPKNPSQFL 269
2_pfamImport 157 LHCIFKLQNHAIHLVVFYERSGHFLWHGQLRLKQNMDKNFVHFRKLHFGRYPGAYSKPNLHLASIDGLQIQVPKQIANFL 236
XP_006626699 157 LHLLFRLRAHAVHLLVFYERSGGYLWHGPLRLRPGADRKFVPFRKLDFGRHAGAFDRTELLLTSVDGLNIRIPKNISRFL 236
XP_010885909 157 LHFLFRLDGYVVHAVVLYERSGNYLWHGLLRLKPNMDRKFAPFRKLDYGQNAGAYDRPELVLTTLDGLDVRIPRNITGFL 236
XP_007668829 160 LHYVFRLAAHTVHLVVLYERSGNYLWHGHLRLKQHVDRKFAPFRKLHFGRHPGALDKPELLHVSIDGIQVQIPKDPGHFL 239
XP_016279768 160 LHYILKLATHAIHLVIFYERSGNYLWHGQLRLKGYSDRKFVPFRKLQYGHYPGAFDRPELLQVSVDGLEVQIPKDLNYFL 239
XP_009455336 160 LHYICKLATHAIHLVVFHERSGNYLWHGHLRLKEHIDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLEVLIPKDPMHFV 239 chimpanzee
XP_030291745 157 LHFLFRLHGHVVQVVFLYERSGNYLWHGALRLKANMDRNFAPFKLLDYGRHPGAYDRPELVLTVLDGLDIRIPRNISRFL 236 gilthead seabream
XP_021331643 157 LHFLFRFNGRVVHVVVLYERSGKYLWHGPLRLTASLDRTFAPFGKLDYGHHAGAYDRPELILTTLDGLNVRIPKNFSGFL 236 zebrafish
XP_013043775 160 LHYIFKLASHAIHLVVFYERSGNYLWHGPLRLKQHMDRKFVPFRKLHFGRYPGAYEKPELLLVSIDDLKIQIPKNPSSFL 239 Anser cygnoides...
GCF47125     241 EERSQSRFIECRYREARSFFQLYPDDTSLDAVEFRRKAK 279
XP_003223799 240 EERSHSRFIECRYREARSFLQVYPDDASLDAVEFRKKAK 278
KYO35108     270 EEMSHARFLECRYREARAFFQLYPDDTSLDAVEFRKKAK 308
2_pfamImport 237 EEVSQSRFVECRYKEARMFYQVYPEDTSQDAMEFKKKAK 275
XP_006626699 237 NEVSHARFLECRYKEARAFYQLYPDDTSQEAMDFRQKAK 275
XP_010885909 237 TEYSQARFLECRYREARSFFQLYPDDVSPEAMDFRMKAK 275
XP_007668829 240 EDISHSRFLECRFKDARAFFQQYPDDVSLEAVEFRKKAK 278
XP_016279768 240 EEVPHSRFIECRFKEARAFFQKYHDDITVEAMLFRKNAK 278
XP_009455336 240 EEVPHSRFIECRYKEARAFFQQYLDDNTVEAVAFRKSAK 278 chimpanzee
XP_030291745 237 NEQQHAHFLECRYRDARNFLQLYPDDSSPEALDFRRKVK 275 gilthead seabream
XP_021331643 237 HEYSSSHFLECRSREAKAFFQLYPEDTSPEAVDFRMRAK 275 zebrafish
XP_013043775 240 EEMTHSRFLECRYREARAFFQLYPDDASVDAVEFRKRAK 278 Anser cygnoides domesticus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap