Conserved Protein Domain Family
FAM220

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pfam15487: FAM220 
FAM220 family
This protein family is a domain of unknown function which is found in eukaryotes. Proteins in this family are typically between 217 and 277 amino acids in length. There are two completely conserved residues (S and L) that may be functionally important.
Statistics
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PSSM-Id: 464743
Aligned: 10 rows
Threshold Bit Score: 294.4
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011444566   6 RDLRDLICVSRLTVRDSDEEvi---------sDDEVvvkdldalsissassvESLKRTNSVERHVSPDSGcvtnsstpPE 76 
XP_001629822   6 RDLRELICISRLSYHGEEEQdpepenlnaaseDFNG----------------NRVPKDTKTKRKSPKKKV--------KD 61 
XP_002599366   6 KDLRDLICLSRLTIRDSDEEm-----------DLSDtdadyg-----nfrtsSSLENGDVFRKD--------------AG 55 
EDV27870       6 EEIRDLLCVSRLSYSAIDDE------------DFSQ----------------QDVPHVTLAKHPFHRSSSypfqqptpPP 57 
XP_001090217   2 RDRRGSLGTCLAQVQQARGG--------------------------------DSNKLSYSLKKRMPMEGLwpa--dapSW 47 
Q6DGF6         2 RAGRGTLGVCLASVKQSQGG--------------------------------DLDKLACGLKRRSEKRNPsps--dvpSW 47  Norway rat
Q3ZN08         2 KAGRGTLGVCLA--KQSQGG--------------------------------DPDKLACGLKKRSQKRNPsps--vvpSW 45  house mouse
XP_007667483   2 KERRTTPDICLKSMKGEEED--------------------------------DSDKLLCKVNIRRQKAFFqqp--eayPW 47 
XP_009028887   6 KDLREFICVSRLTVQDSDEEhaditnyykdtnDDGNnlstrnsflhspdsgiQSLTRN--------------------DP 65 
XP_027730108   5 RDRRTTLGSCLINMKGKEDV--------------------------------DSSKLFCKVNKRQQKEIPhls--dtcSW 50  common wombat
XP_011444566  77 TAIEADVTPKRTKPKKRKKrdkkpmfdiipgtfdlPKAEVLPPVASTSYGSILSETQDVDDVSS------------PVVD 144
XP_001629822  62 KAISGLESHKSPRLSPGGS----------------SKAVILPPIRNSSAGSSGSSSGRNSPASSltneelqpcrpfSSIA 125
XP_002599366  56 VASSILATQRTSTASKDELfephv-------nlrrSKKAPLPPVGIGSRPSSSASSGSDTAPDA------------RSVG 116
EDV27870      58 GASGTVKSN-SAKVRSGRVlsplsditkkkedirpNSGPVRPLHTINSKATSKTPQTIAKQQAV------------LPSI 124
XP_001090217  48 MNKPVVDGNSQS---EALSlemrkdps-gaglwlhGGGPVLPYVKESVRRNPASAATRSTAVGL------------LPAP 111
Q6DGF6        48 TDQPVADTHGKSRAMAAASsemkrdqs-kaslilhSGFKALQYLKESMGRNSTPAASLSMAVVL------------SSAP 114 Norway rat
Q3ZN08        46 TDQPVADSHGKSRATGAAAsemkhgqs-kasllhhGGFKVLQSLKGSVGRSSAPAASLGKAVAL------------SPAP 112 house mouse
XP_007667483  48 LNQSDFYFN-MNLPKELFSlnvknassikaallhhNGKKISPPLRETPTI-STLATTQRESVDK------------SFSP 113
XP_009028887  66 TDVDVENVGVRDRTNVKKSiqksrf----yapsksSNNTRLPKITTTKKNHVEAQSSGVQ-------------------- 121
XP_027730108  51 SNKPGVDFN-RSLHKEPFSsemknyls-kadplphIGNKMPPYLRKSTRRNSTKAAAQKESVNV------------VFPA 116 common wombat
XP_011444566 145 KrvrskGTNFDDMMCYIDATVVSTWLARANKSVQNLCDFCLNAEKFVQFSHFWLSDFPDQQKNEIFELEYEIIVEEANFA 224
XP_001629822 126 KkyqprKTNFDDVLVYMDATVIAEWLSRANKSVQSLTSWLHSGCNFVHFAHFWLSDLVDSKRRDAIDMEFSIVMDEVQFA 205
XP_002599366 117 H-----DGNFDGILGYMDEAVIADWLMRTNVMVEELSDWCCHGDNYVRFAHFWLSGIPPAQRTQLIGMEVGIVRDEMERA 191
EDV27870     125 Qpl-ikTEDLESIITRVDSNILENWLKESNKLVMRLHEWWQTGDNMTQFSHFWISVFPSQQKLDLLKMELEIIRDHLIIL 203
XP_001090217 112 ------TECFAQVACSGVEALERDWLGGGARATDGHRGQCPKGEP-------RVSRLLCHQKL----PEMGSFQDDPPNA 174
Q6DGF6       115 S-----EEHGAGVSGGIGDTLGSDWPAREPRTTDSCGQYL-KGEA-------WVSGWQGHPKV----REVGFLRGEPLSA 177 Norway rat
Q3ZN08       113 S-----EEQLAGMSHGIGDALGSDWPGREPRATDNRGQYL-KGES-------WVSGRPGHPKL----REVGFLRGEPPSA 175 house mouse
XP_007667483 114 I-----KEHFIKGSFCIDKPTVSGWLEKVLCSLNDLRDWCHKGDNFVCSANIWLSRLSYNQKLILLPLDMGIIEDEQQSA 188
XP_009028887 122 ------YTDVDSTLKYLDSNVVAGWLTSCNDEIHKLTNWLASISNFCNFVSFWLSECKKEDKKCLIQMEHDIIMDEISFA 195
XP_027730108 117 K-----EH-FAKIFCSINEAVVSDWLERAICSVNDLKEWCHIADNFVRFANFWLSELPYKQKVNLLQLEKGLLEDELQSA 190 common wombat
XP_011444566 225 FAVGRDQRKVINRDILSLISAIFREYP--GVLLSSKGPYMFLDYLHVLSSDKQTSYKRLLSDVKCSTRNKQFAQWILAMR 302
XP_001629822 206 FGVGLQGKEISMEDIRSLTTAIFWEYP--GKLSDTENQHYFLTMLICLCSGRQDNYKSLLSNVRCSTNNKQFAQLVLATR 283
XP_002599366 192 FRTGRESGDVTSLALRKLLSAVLREYP--TKLLTSKGPHIFLEKLDVLTSGRSEEYRATLTDVKVRTRNKQFVQWVLALR 269
EDV27870     204 L--GGQQSQLEESTLEQLIYAIIPEFP--TRFAVNR-QLFFLDVVYTLSSGRHKAYKKLLSAVKCKTSNRTCAQIVLAIR 278
XP_001090217 175 LPKGL-GSELEPSCLHSVLSATLHACP--EVLLNDETKRVFLDRLKPMFSKQTMEFKKMLKN---TSDGLQITLGLLALQ 248
Q6DGF6       178 VPKGL-GTRSELSYC-SELCQLPYTYPyyEALPEDKTRCVSLDHLSPVFSEETVEDEKTLSS---TSDGLQIVMGLLALQ 252 Norway rat
Q3ZN08       176 GPKGL-GTWSELSHRYFELGQLPYAYPyyKVLPEGELRCVSLDRFNPGLSEETVEDEKTLKFFRWSADSRGVTGSAIFQI 254 house mouse
XP_007667483 189 FLEGVSSEFL----LNSMLSATLCEYT--AVVLNDEAKYSVLGHLNPETSEQTTEYKKMLSSLPCTTNNLQIALWLLVM- 261
XP_009028887 196 FSSGVNSKTISKHQTAYLLKQIFHEYPd-KLLSNNKHNNLFIDYLVTLTSKNKSLYKKLLSDVKCRSSVKQYIQDILAMR 274
XP_027730108 191 FFEEV-GTELELSHLCSVLSATLCEYP--EVLLNDETKYVFLDYLNLMSSEQTIEYKKMLSSLKCTTNNLQValwllalr 267 common wombat
XP_011444566 303 SFTLL 307
XP_001629822 284 SFTIV 288
XP_002599366 270 AFALL 274
EDV27870     279 SHALL 283
XP_001090217 249 PFELA 253
Q6DGF6       253 SSRLT 257 Norway rat
Q3ZN08       255 SKSLM 259 house mouse
XP_007667483 262 CLCTS 266
XP_009028887 275 CFCLI 279
XP_027730108 268 afala 272 common wombat
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