Conserved Protein Domain Family
Afaf

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pfam15339: Afaf 
Acrosome formation-associated factor
Afaf is a family of single pass type I membrane proteins. Afaf is a vesicle factor derived from the early endosome trafficking pathway that is involved in the biogenesis of the acrosome on the maturing spermatozoon head.
Statistics
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PSSM-Id: 464659
Aligned: 8 rows
Threshold Bit Score: 250.941
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2LCV6         63 PANEKTGNYYKDIKQYVFTTPDSK-GtkTEVSVTAT---TDLKFTM-KDYKSSKATAS---------GEEDK--RSEPSR 126  Norway rat
Q9D9V2         64 PANEKTGNYYKDIKQYVFTTPNIK-G--SEVSVTAT---TNLEFAVkKNYKASKPTAS---------GEEEK--PSESSR 126  house mouse
XP_008248910  218 PANEKSGNYYRDIKQYVFTTHNPN-GseSEISVRAT---TDLRFAL-KNYKLGNASAEk--------PSEEK--PSEPSH 282 
ELW70236      307 PADDNSHENFRDVKQYVFTTQNAN-GseSEISVRAT---TDLKFAL-KNYKMINKTTSekp----isEEEKS--VPESSH 375 
Q9NQ60         53 PANEKNGNYYKDIKQYVFTTQNPN-GteSEISVRAT---TDLNFAL-KNDKTVNATTYeks----tiEEETT--TSEPSH 121  human
2_pfamImport    1 PANEKSGNHYKDIKQYTFVTQGPN-GtgPEISLRAT---TDVNFIL-RNFce-------------asKDKTE--DKEKKE 60  
3_pfamImport    1 PANEKTGDHYKDIKQCKFITHHSSyGlsSHVLIRCTslkTINSFSL-----FLDKPNKatrydkpttEEEES---QETYH 72  
XP_023620518   60 PYNDKNDHHFKEEKNYVFTTQTPT-GsqSEISVKAT---TAVDFSL-RNyk---------------lNETSEapSEEPSI 119  little brown bat
Q2LCV6        127 KSST-----PNVPAFWTMLAKAINETAV-SMD---DKDLFYQAIPASDLNSTN----EDQLSELEEIKLKLMLGISLMTL 193  Norway rat
Q9D9V2        127 KTST-----PNIPAFWTILSKAVNETAV-SMD---DKDQFFQPIPASDLNATN----EDKLSELEEIKLKLMLGISLMTL 193  house mouse
XP_008248910  283 KNIQrt--tPNLPEFWTMLAKALTQSTS-GFE---GND-LFKPIPGSDVNATN----QDKLSELQEIKLKLMLGIALMTL 351 
ELW70236      376 KNIQ-----------------TISETTK-SMD---DKDQLFQPIPSSDVNATNeeeeEEELSELDEIKYKLMLGISLMTL 434 
Q9NQ60        122 KNIQrs--tPNVPAFWTMLAKAINGTAV-VMD---DKDQLFHPIPESDVNATQ----GENQPDLEDLKIKIMLGISLMTL 191  human
2_pfamImport   61 NEKTeptkgQNEPEFWTMLEKALNATPP-REQrneEKDQLFNPIPSSDVNLES----KQEAGELEGIKQKLMLGISLMSL 135 
3_pfamImport   73 NSFQks--tPNVPAFWTMLAKALNGSAVyNMD---EKDQLFHLIPRSDLLMAN----DDKISELEELKIKLMLGISLMTL 143 
XP_023620518  120 QRIpkttevPNEPAFWTMLAKVLNETVP-EEE---SRDQLFQAIPSSDLNATS----EDQGVEAQDNKLKLMLGISLLTL 191  little brown bat
Q2LCV6        194 ILLIPLLIFCFATLYKLRHlRDK-TCES-QYSVNPELATLSYFHPSEGSNQTVLTEESSFL 252  Norway rat
Q9D9V2        194 VLLIPLLIFCFATLYKLRHlRDK-SYES-QYSINPELATLSYFHPTEGVSDTSFSKSADSN 252  house mouse
XP_008248910  352 LLFVTLLAFCSATLYNLKQlSYK-SCES-QYSINPELATLSYFHPSEGVSDTSFSKSAESS 410 
ELW70236      435 ILFATLLAFCSIMLYRMKQlSYK-SCQS-EYTINPELATLSYFHPSEGISDTSFSKSAESS 493 
Q9NQ60        192 LLFVVLLAFCSATLYKLRHlSYK-SCES-QYSVNPELATMSYFHPSEGVSDTSFSKSAESS 250  human
2_pfamImport  136 FLFLALLTLCCATLYKLRKlSSKsECDDgQYSVNPELAEMSYFHPSEGVSDTSFSKSAESS 196 
3_pfamImport  144 FLFLILLGLCCATLFKLKRmGQN-DYES-QYSINPELATMSYFHPSEGVSDTSFSKSAESS 202 
XP_023620518  192 LLFTILLASSSALLYKLKT-SYNkQLER-QYSIHPELASLSYFQPAQGVSDssfsrsaess 250  little brown bat
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