Conserved Protein Domain Family
ALS2CR8

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pfam15299: ALS2CR8 
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8
This domain is found in amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein.
Statistics
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PSSM-Id: 464625
Aligned: 14 rows
Threshold Bit Score: 185.312
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002432215   83 EKQLPGRGSLMFKssSD---VSVPFFGSPFTVETTI--YYTCSQGIKYY-----GSKQYPDEMFRQGDPLS-KKRRKPKI 151 
XP_009857571   61 KDWQKSSHFISFE--SErgnIRIPFDGIPFMVIGTK--VLQCQHGKDSHk---kSKERYKQMKERGEYPPSkKQRTLTNP 133 
3_pfamImport    1 KDWQSGRHLISFE--SDrgnVRIPFDGIPFMVIGTK--VLQCQHGKDSHk---rSKERYREIKESGNYPPNkKPRVLTNP 73  
EEN67667       58 NVQPSAKKSINWK--LK----YVEFDGVPFQLVSKA--VYGCHQGEDRDkp-kkDKRKAEKQQQALEDHGFlRRHRQVQD 128 
XP_002119213   58 DWKPSAKERIYWEhpLPngsVSIPFDGFPFMFVGRK--VLLCQFGKDMEkdrrdKRYNELERLRSVNPENY-PKKRRRKQ 134 
4_pfamImport    1 LDVLKIKTSISWS--SKrd-tSIKYDSVPYIWLGID--TYICQYGPDVDlk-ikEKYRLKTERKVMDDQPY--KRRKRRI 72  
2_pfamImport    1 ASYDLLKARVRWD--TT--------TQVPYMIIRTI--KLECQHAKDRNkl-knDRYKQLTALQRAEENMKkKTYMRTQG 67  
OCA23229      217 PSPAKPATRLMWK--SQ----YVPYDGIPFVNAGSRaiVMECQYG---------PRRKGAQPKKSAENDNM------SGG 275 
XP_016860453  149 PSPAKPATRLMWK--SQ----YVPYDGIPFVNAGSRavVMECQYG---------PRRKGFQLKKVSEQESR------SCQ 207 
XP_005167554  232 PSPAKPATRLMWK--SQ----YVPYDGIPFVNAGSRaiVMECQFG---------PRRKGVQPKKGSEQEKY------QNK 290 
XP_002432215  152 TKKIGCQARMTVKKIKVFPSEdyLVSRNN-WREKKVAIDQLKNDf--LNNKPVE-SINRYCIVISLDISHNHEAKlkiPK 227 
XP_009857571  134 TKKKDCPATIHLREVVTFPEF--QMLKDT-ARYRRKISCDIRTL---LKNDPSK-IQMERRIYILLPFINEHRFH---II 203 
3_pfamImport   74 TKKMDCPAAIHLREVVTFPQF--PVKKDT-ARYRRKISCDIRAL---LKNDPSQ-IQMDRRIYIVLPFINEHRFH---LI 143 
EEN67667      129 TKKMDCPVKFTVHYLIRFPDF--KIEEDK-QSAKDKVSKALKEA---LAKDPSA-VKAVWEYRTRFPAMDDHRNH---PT 198 
XP_002119213  135 SIKIGCPATVNLVQIAKFQSYkyHVAKNS-KRQRRTAADKLRQD---LLNGAE--VDVKMMFIKKASALSEHEGH----L 204 
4_pfamImport   73 SKKLGCRAVAKMIHIIKLPKY--RVETNStLYSRNQAAAKFHTD---LKNGDVEkIEMNQMFILYFSDIDQHNGH---PI 144 
2_pfamImport   68 SKKANCTATIGISEIVKFPQY--KKEEGV-AMSTYDQRKNIKSLklaLAIGDES-LIGEKACYVAFPSISDHSGH---AV 140 
OCA23229      276 LYKATCPARIYIKKVKKFPNY--RVPTDP-KIDKKLIRMEQEKAfnlLKKDLDG-TDGVLRWYMQLPDQEAHQYH---DL 348 
XP_016860453  208 LYKATCPARIYIKKVQKFPEY--RVPTDP-KIDKKIIRMEQEKAfnmLKKNLVD-AGGVLRWYVQLPTQQAHQYH---EL 280 
XP_005167554  291 LYKATCPARIYIKKVRKFLEY--KVPIDP-KVNKKVVRQEQEKAffnLKNSLWD-DGGVVRYYVQLPTEKAHLYH---DV 363 
XP_002432215  228 KPKQRQFdpakkvlklheqfqeavvmlnselitkctnisiltgccnsLKSIINQLKDSIAredgvpiDLIT-AAIDKITQ 306 
XP_009857571  204 GQCNPNL----------------------------------------KQNVDPQLVEKIY-------ELVNvSGVDSIDE 236 
3_pfamImport  144 GQCNPNL----------------------------------------KQIMDPDIVEKIY-------EQVSlHGVDNADE 176 
EEN67667      199 VGMVAEL----------------------------------------SQPVDDRIRQQVE-------KITE-GGAKTVSE 230 
XP_002119213  205 VCVENTLasariqgdrn---------------------ilafdclqeTDEMEDLIKEIYD-------EKYLtELLIELRR 256 
4_pfamImport  145 LGVEN------------------------------------------QSRSDEMVKKE---------KFIMnNAIQRIPA 173 
2_pfamImport  141 GEAAGSL-----------------------------------------QPLDPRVITKIG-------ELVA-AGLTSKKE 171 
OCA23229      349 ETGC--Fspstfqpsied------------------eeeilcdensqPSRLHPQVAEKIR-------DLVS-KGLSEVYS 400 
XP_016860453  281 ETPCLTLspspfpvsslee----------------eetavrdencalPSRLHPQVAHKIQ-------ELVS-QGIEQVYA 336 
XP_005167554  364 ETVN--LpplpdqicftedhpheeedteelgfqamqdvlvedgvslpESRLHPLVAEKIC-------ELVA-HGHNQVYT 433 
XP_002432215  307 KQLKSAATLeKKNLaAAKKKQFKTEKlikvepceeinanAFVAKVENNENQIIELSSVM 365 
XP_009857571  237 MVQLLKNFV-LEIF-VGKKMPPVSNK-------------RFYPSKKDIREHMANAVAKL 280 
3_pfamImport  177 MTQILKRFV-AEIF-AGKKLPPVSSK-------------KYYPSKRDVKEEMTKALATF 220 
EEN67667      231 VKHHLSTFItNELF-RGETPPPTTQR-------------KYYPTDRDLWNIMAKVNDST 275 
XP_002119213  257 FKTCIKSFVhNAPI-LQHDQSDRKRKlpmelldkimkypRFSPPDRDLINNPGVFGQDF 314 
4_pfamImport  174 VDRRLKVVL------NGSGYPKKERK-------------QNRRHPRTIINVLCEVDSTQ 213 
2_pfamImport  172 IKSHLQIYVeQELF-KDQKPPSLANR-------------RFFPTIKDIRNHFTSFKKRK 216 
OCA23229      401 VRKQLRKFVeRDLF-KPDDIPERHNL-------------SYFPTVNDLKNHIHEAQKSL 445 
XP_016860453  337 VRKQLRKFVeRELF-KPDEVPERHNL-------------SFFPTVNDIKNHIHEVQKSL 381 
XP_005167554  434 VRKQLRRFVeREMF-KSEEVPERHNL-------------CYFPTVNDIKNHIHEAQKTL 478 
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