Conserved Protein Domain Family
DUF4534

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pfam15049: DUF4534 
Protein of unknown function (DUF4534)
This family of proteins is functionally uncharacterized. This family of proteins is found in mammals. Proteins in this family are typically between 170 and 190 amino acids in length. The protein includes the human integral membrane TMEM217 protein.
Statistics
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PSSM-Id: 464470
Aligned: 24 rows
Threshold Bit Score: 178.198
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023402904  21 AKKYCFIVGIFSILNTIQFLLFDVNYVVNFGYRDSlFSIYKETHLDQDYWVISNMKAIKICLSIITLIVSCTLLYCIHMN 100
ELW66107      48 PKMGTVLSAVFTIMATDLYLIFEQKYLQDNNCTKA-SQQDRRAGNTVYQFAICSSATIVLLLSVVTIFVSCFLLYSAYAQ 126
XP_004846720  23 ARRGTVLAGAFSIMATHLHLIFEWRHLAWGDCPDT-SQASESSGDVVRRFVTCWSLAIVLLLSVVTMAASGLLLYSVYAQ 101
XP_017443531  11 AKMGTVLSGVFSVMATHMHLIFERKHLGNGNCT---DNVHSQGINILSHFFICWSFKIVLTLSLITMLVSCFLLYSVYAQ 87 
XP_008261074  40 AKMGTVLSGVFTIMATKMYLIFEEKHLGNHNCL-K-TGPQDSADDAINEFIICHSWKIVFYLSAFTILVSVFLLYSVYIQ 117
XP_003789363  11 AKMGTVLSGVFSIMATILSLIFEEKYLMFGNCTEK-ELETMHTSEIINEYITCWSWGIFLLTSIITIIISCFLLYSVYAR 89 
XP_003404262  11 AKMGTVLSGAFTIIATSMYLIFEEKHIQSGNCTEI-KSQDQGIET-IREYIMCWSFKIVVFISSITLVISFLLLYSVYAQ 88 
ELK16566      11 AKIGAVLSGVFTIVATNLYLIFEGKYIRSSNCTDF-NPRNKSIHILINHFVICWSFNIVLFLSCVTIIVSCLFIYSVYAQ 89 
XP_006104456  11 AKMGTVLSGVFTIIATDMYLIFEQKYLRSSNCTEI-DPGDMRIHSLIRHFVACWGFNIVIFLSCITIIISCLLIYSVYAQ 89 
XP_001927679  11 AKMGSVLSGVFTIMAIDLYLIFERKYLMKGNCTEL-SSQIKGTGMLAKQAIICWSWTIVFCLSFITLIISCLLLYSIYTQ 89 
XP_023402904 101 ICLGMLTYAIWIIIYEVFNFPLALLLKDsvRNLFEELSYLHLIFQISRMLLHFCCLPFIIKQMLIIYKDPKMSSKMGRRR 180
ELW66107     127 VYKGLMIYVIWIFFYEIVNLTIQILTND--NLDILEVRVMRWFGLVSRVLAHCFWMYFVITYASKMYKEQNQGRIFPHSR 204
XP_004846720 102 VHRGLLLYVSWIVFYEAANLAVQILSTG---TSTGAVRVLRWFGLVARACMHYFWLWFVITYARLSYKNQPRGDILAYSR 178
XP_017443531  88 IYEGLMSYTVWIIIYETVNLAVQTLTDE---FSVALVRAMRWFGWVSRASLHCFWLYFVVTHAQIIYQSKKQGNIITYHR 164
XP_008261074 118 LYRGLMTYVIWILFYETVNIIIQVLTNT--DLSPTEVRVLRWFGLVSRAFMHCFWVFYVIAYAHIIYKTQSQGNILYYNR 195
XP_003789363  90 IYKGLLIYGIWILFFEAINVVIQVFTNV--DFPFEEIRIMRWFGLVSRISMHGFWMFFIITYIHISYKNNTQGNIVFYNR 167
XP_003404262  89 RLRGMVIYIIWIIFYEAMNIVIQVLTNT--NSSIEMVRMMRWFGLMSRVVMHCYWMFFVITYTYILYKSKSQGNILSYNR 166
ELK16566      90 KCRGVVTYIIWIFFYETVNIVVQILSNN--DNNVGEVRVMRWFGLVSRIFMHCFWIFFVIIYAHIIYENKNKGNIISYNR 167
XP_006104456  90 KYKGMVIYIIWIFFYEALNIVIQILTTK--NTGIVEVRVMRWFGLVSRIFMHCFWIFFVMTYAQIIYKSNSQGTIISHRR 167
XP_001927679  90 IYRGLLIYIIWIFFYETVNIVIQIHTND--DSNPEEVRILRWFGLVSRTLMHCFWMFFVITYAYVIYKNQSPSNIISYNR 167
XP_023402904 181 HSSI 184
ELW66107     205 RIST 208
XP_004846720 179 PGSA 182
XP_017443531 165 RISL 168
XP_008261074 196 RISM 199
XP_003789363 168 RPSI 171
XP_003404262 167 RISM 170
ELK16566     168 RIST 171
XP_006104456 168 RIST 171
XP_001927679 168 RIST 171
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