Conserved Protein Domain Family
P_C10

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pfam14974: P_C10 
Protein C10
The function of this protein family is unknown. Mutations in protein C (C12orf57) are implicated in the pathogenesis of colobomatous microphthalmia.
Statistics
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PSSM-Id: 464416
Aligned: 18 rows
Threshold Bit Score: 84.2539
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003064072 170 MTLAQAHAAIDEVTAVVRVPANAARIAAIKKQVDADpdnAMMAMFSFMPLANELMGPAMKKYGYAdqENGGGLMPFLNAL 249
EDW28883       7 FNNENAKQILMDIIRCVNQPDNSKKLSEAKASAGKE---MMLMMQHVFPLVMQLQLEVIKSHGFP--GNREGLVQFSQLI 81 
ETN61432       7 FNAETGKTILVDILKTVNQPENSKKLGEAKANSGKE---MIKMMQHVFPLVMQIQISVIKDYGFP--GNREGLVQFEQII 81 
Q6P7L0        16 LPLEQVKEALGEVLNALQSPTGSARLEEARENSGND---LGKVLQLLLPAAVQIQQEVLQNYGFS--PDGEGVLRFARLV 90  tropical clawed...
XP_003227158  17 LSAEQAKVILAEVIKAFGSPENAQRMEEARDNACND---MGKMLQFLLPVATQIQQDVIKAYGFS--NDGEGVLKFARLI 91 
Q6TH01        11 LTVEQARVVLSEVIQAFSVPENAARMEEARESACND---MGKMLQLVLPVATQIQQEVIKAYGFN--NEGEGVLKFARLV 85  zebrafish
EDO36913      10 LTSEQIKCILREVLSAFDEPENKVKMEVIFDSSGAN---LVALMHQLVPAAAAIQRNVIQAHGFP--SSDEGVLRFTQMV 84 
2_pfamImport   1 LDKTRVQQMADQVLDAFTHQRTKQKLQRALALAQGD---LGLICHKYLPVAIEVFAHVVSRYGFA--ESIEGVMESVRVM 75 
EEC03509      11 FNSEKAKGALEDILAAFEHPENYARVQNAKDVAGND---MLKHMQVVFPLLTQIKMEVIENYGFT--PDGEGVLQFAQLI 85 
EFX90094       8 FDAEKAREACTDILAALSQPGNAERLARARELAGTD---MVKVMREVFPIVTQIQLEVIQRFGFP--GDGEGAAQFLQLV 82 
XP_003064072 250 QE-DRGDDALRDKARTLRKLVVPESMLP 276
EDW28883      82 REmERDDMEIARLRSQIRAIYLPPIAIN 109
ETN61432      82 REfEREDVDIARLRAQIRSIYLPPININ 109
Q6P7L0        91 KSyESQDPEIAAMSSKLKSFFLPPLPLP 118 tropical clawed frog
XP_003227158  92 KSyETQDPEIASMSGKLKSMFLPPMTLP 119
Q6TH01        86 KMyETQDPEIAAMSVKLKSLLLPPLSTP 113 zebrafish
EDO36913      85 NFfAKDDPEVETLANQLRTKFIPQMPVP 112
2_pfamImport  76 QTlAKDDEQLVQKLSNIRKLLTPTA--- 100
EEC03509      86 RQlEREHPDVARLNAELRAQFIPPMVPP 113
EFX90094      83 RSlEKEDGEVGRLSDELRAHFLPPMTAP 110
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