5C6D


Conserved Protein Domain Family
USP7_ICP0_bdg

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pfam12436: USP7_ICP0_bdg 
ICP0-binding domain of Ubiquitin-specific protease 7
This domain is one of two C-terminal domains on the much longer ubiquitin-specific proteases. This particular one is found to interact with the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110.
Statistics
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PSSM-Id: 463580
Aligned: 103 rows
Threshold Bit Score: 176.932
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5C6D_A         61 IRLWPMQARSNGTKRPAMLDNEA-DGNkTMIELSDnEN---PWTIFLETVdpelaasgatLPKFD-KDHDVMLFLKMYDP 135 
EFX71348      627 FRIWPMAGRTNNTMRPKALDWES-DLGkCVTDVAD--Nc-nPWTCFLELLppds--glsaLPPFQ-QDRMVLLFFKYYDP 699 
XP_001948017  625 IRIWPLIASKHESLRPMYLDGEA-NALkTIQDLHD--SsstTWNIWLELVepg----vssLMPFD-RSNQSLIFFKLFIP 696 
ETN64231      639 FRLWEVKKPSNL--KPHRFEYIEpVATeTCAKYAS-PEtkhSCTIFLELPapgg---pgvLEPAKlSFDDTLLFFKFYDP 712 
1_pfamImport    1 IRIWPSYPHRTQGQKFVYFDVNE-DIHkQLINVES------PWFVFVELLrpdc---pgiIQPFD-RKRDLFLFFKFYDP 69  
EDV95916      568 MRLWGMCSIAAKDQKFMYIDVEA-YAMrTLNEIPN--DvqkPWCIFLELAqadc---pgrLPPFN-PQLDVLLFLKFYDA 640 
XP_001966137  662 MRIWNMCT--AQTQKFLHFDFEA-EASrTIEQIPT--Sq-kPWVIFLELAspen---papLPPFN-PKTDVLLFLKYYDA 731 
XP_004225844  625 FRLWLFSQRPNNSWRPTLLETGE-TVGkHLIEVAE--Ne-nPWHLWLETIqpds--tedtLPAFD-KQGDILVFLKMYTP 697 
EDV28289      560 MRPWPLFHRPNGTTRVIGLD-EA-DYDrTLFDLAD--Nd-eNWFIFLETLlpds--glksLPPYD-KNSQVIVFLKYYDV 631 
EDO34745      602 IRPWPLQQRSNGTTRPAVFDMES-DIDkPIGQLVDa----sSWVIFLETVdpen--gtapLPSYD-KKGDVLLFFKYYDP 673 
5C6D_A        136 KTRSLNYCGHIYTPi-sCKIRDLLPVMCDRAGFIQDTSLILYEEVKPN-LTErIQDYDVSLDK-------AldELMDGDI 206 
EFX71348      700 TTRQIHYAGHHYALi-kRPLADLVPILLQRAGLPPHTQLELYEEVKPGmIDT-IEHIDKPLETi-----lE--ELMDGDI 770 
XP_001948017  697 EERLLVYCGYHFASf-eTPLDSLINIMNKRAGFEEDTKLAIYKETNKNeIEK-ITKLDDPICEi-----iQ--TSTYGEI 767 
ETN64231      713 VDKRLNYCGHGLYKp-sMTVAELVRDLNRRAHFEPDTELQVYEVVDINkAQK-ISDQQQTLQQa-----lS--LLGHGTI 783 
1_pfamImport   70 IKKCLTYLDHGQYQl-sTRVRDIIPHINKTLGFDENTELSVYEECPSNtVQK-ITNLNDTLEKvlsqlsrD--NSVQGFI 145 
EDV95916      641 RRQHLNYIGCTQQPl-nRRLCELVPEINRKLGFASNTKLTVFDEYA---GWK-IHDLEEPIGNlln--maP--KQLQGTI 711 
XP_001966137  732 RNKRLNYIGCTQQPq-sRRLIDLVPEVNRKLGFEPDTELTVFDEYA---DKK-IPNLCEPIESvly--ipQ--DHLQGHI 802 
XP_004225844  698 STRTISYCGHVSVPiegTSVVAMEKTLRKRGGLPPNTPLLLFEEISASeLRP-IHDRNLQFGEv-----mD--KLMDGNI 769 
EDV28289      632 MNRKTSYVGHLYIEl-sMSLDDIAKKCREFVSIPSSVPLLFFEEVKPNrVDI-LTDTSIPLLKv-----mG--DFTDGDI 702 
EDO34745      674 AQRVLALVGHLYVPl-vTKFSELMPYLCEKAGLPQGTPLFMFEEVKINyAEQ-IRDTSLTIEHg-----vE--ELMDGDI 744 
5C6D_A        207 IVFQKDDPEn----------------------DNSELPTAKEYFRDLYHRVDVIFCdkTIPN-DPGFVVTLSNRMNYFQV 263 
EFX71348      771 ICYQKYDPEv----------------------MGSQLGTVKKYFYDLLHRIEVTFCdkTNPLdVTGFTLSMSEDLGYDQV 828 
XP_001948017  768 LIYQKEELV-------------------------KTYPSVTDHFKNICSQVYITFCdkLIPNd-PGFTLGLPMWMLYHDM 821 
ETN64231      784 VVFEKRHPPg----------------------DNLEFPTCEAYFKDLFCRMEVVFLdtLIPNd-TGFTLDLSSESTYDQI 840 
1_pfamImport  146 LIFEKRIATnldsvdgfignqqntvvhpqynsLKLELPTVDHYFRDLMHRIEILFIdkTIPNd-PGFTLELSNRAPCTAM 224 
EDV95916      712 LIFERENVD-----------------------AKLDLPTVADYLMDVVSRIEISFSdkANPYe-PDFTLELSPRCNYDQL 767 
XP_001966137  803 LIFERENVD-----------------------DKLDLPTVEDYFMDLVYRIEIIFSdkCNPNe-PDFTLELSNRYNYEQL 858 
XP_004225844  770 IVFQPVEPS---------------------------CPDAARYFLDVFFRVDVILCdkNDPLd-PGFTVSLNRNWTYGQF 821 
EDV28289      703 LCFQIDSKDe-------------------------KIPTVEDYFRELFNRIDVKFFdkNVSNd-PGFTLTLSQRMHYIEI 756 
EDO34745      745 ICYQRSDNEl---------------------lETSELPTVIEYFRDLHHRVEVLFCnkNQPDd-PGFTVVLSQRMNYTQV 802 
5C6D_A        264 AKTVAQRLNTDPMLLQFFKSqG-YRDGPG-NPLRHnyegtlrdlL 306 
EFX71348      829 ARLVGDRIGYPPNMLQFFKS-QgYREGPG-PSIRYhwetslkemV 871 
XP_001948017  822 LQAVAERVSVDQRKLQIYFSvNgQKECPG-EPIKNsyngpirdli 865 
ETN64231      841 AKAVGRRINVNPYEIQFFKS-KnYSDLPG-QPLSHsfggslrdvL 883 
1_pfamImport  225 AQAVAEKINTDINRILFFKC-LgYKDTPG-SSVRPlhensikdlL 267 
EDV95916      768 AQTVAVHLNTDPTKLQFFKCiSyDWKMPG-VDVPYtytgtindlw 811 
XP_001966137  859 TNAVAERLNTDPQKLQFFMCiNnYKETAG-NAVPYtfkgtvkdlv 902 
XP_004225844  822 AEKVAERLDTDPMMLQFFRV-QnVRDQPG-NVIRSsfdgqlkdlL 864 
EDV28289      757 ANAVASHLSIDPMMLQFFKSyQpYRDAAShHPIRCsfegtlmdlf 801 
EDO34745      803 AKAVATHLEVDPMKLQFFKG-QiYRDAPG-NALRCtfegtlrdlL 845 
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