4DHJ


Conserved Protein Domain Family
Peptidase_C65
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pfam10275: Peptidase_C65 
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Peptidase C65 Otubain
This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localization signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.
Links
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Statistics
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PSSM-Id: 431191
Aligned: 20 rows
Threshold Bit Score: 204.05
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4DHJ_I    36 DEQKSVPL-VATL----APFSILCAEYDNetSAAFLSKA---------TELSEV--YGEIRYIRGDGNCFYRAILVGLIE 99  Caenorhabditis elegans
Q2H586   170 APHTQGPL-VGKK----TPSSAIMEQYADa-DAIYVQKT---------MALPQT--YSDYRPIQGDGNCGWRAIGFGYFE 232 Chaetomium globosum...
Q7SI56   234 yqpelnglpVGDK----LPSTAITEEYAKa-DPVYVQKT---------RSLPAV--YSHYRPMLGDGNCGWRAIGFGYFE 297 Neurospora crassa
KIS69951  28 ESTSHQAL-ISAV----EPIEVLEKEYAA--NRAFLGKI---------KWLKEEagFIGLRRAKGDGDCFYRAFAFAFIY 91 
CAM59837  19 REVAHYPL-LSLSlp-lNKESMIVKEMEH--DDAYLAQTlslfgaspvSTKQYD--FDSIRYSRRDGNCFYRCAGFRLCE 92 
Q57ZU6    21 SEIDAAPL-LSPTveklGDGCNLMTEFSD--NPPMLVKVvs-----lwRNEETK--YKGIRYARRDGNCFYRSVVFGMHE 90  Trypanosoma brucei
Q4DPS6    17 SEIESVPL-LSDPvealSETCSLVKEFAN--SASILPKVlsl----faSDNDDR--YSGIRYARRDGNCFFRCVVFSLLE 87  Trypanosoma cruzi
Q7XPN5   230 DSCKTRDK---------KPIVDLADEFE---NNTIKKKI---------TLLSEK--YDFFRPVDRDGSCFYRAFIFSYME 286 Japanese rice
Q5KB39    20 ENTSDKPL-VSTP----VPLSVIREEYLKg-SQQIVKKL---------DYLQENg-WDQVWRARGDGDCFYRSFTLAYLL 83  Cryptococcus neofor...
A0E9B0    29 EIEAQDPFiITQP----IELQILESEYLQ--NQGFLQKI---------QKIRQS--YPQFRRVRRDGSCFYRAVLFRIFE 91  Paramecium tetraurelia

4DHJ_I   100 IMLKDRA------RLEKFIASSRDWTRTLV---ELGFPDWTCTDFCDFFIEFLEKIHSGVHTEE-----AVYTILNDDGS 165 Caenorhabditis elegans
Q2H586   233 TLVKSGSk----aRIEAERQRLEGLNSLIEn--VGEFSPYVSQDFVDETLALLSKMAALVGHREqa-mtELREAFNTPSI 305 Chaetomium globosum...
Q7SI56   298 TLIKLGNk----aQVDGERERLESLNEYIQh--HGGFDPMVFVDFVEETDELLKRISDKLNVPEea-msEVMHAFTDAEK 370 Neurospora crassa
KIS69951  92 KIMMMKDr----pMHHFTVKHVESTLQLLK---HAGFDEEVVTDFYEPLKNLLNRMYSTDPESQelnehALLQAMNEPEQ 164
CAM59837  93 LIVEHPD------RAAEYVALLKSREESLS-----RLFGLFVFDFTDALAEILKGVADKTITSVa----QVYNRFISDDG 157
Q57ZU6    91 SLLNNKE------RAGAHLERITDLSRQVV-----ADYGNFAEDFCHPAVEMAKKIESGECSTV-----EQLYELSTNGE 154 Trypanosoma brucei
Q4DPS6    88 SMLGDNE------LTARYLEQATELRTKLI-----EDYGDFVEDFCDAAIAVIRQIESGGCTTS-----EELYALATSHD 151 Trypanosoma cruzi
Q7XPN5   287 RIVAMQDdleriiEVSRIGERIGKYKQAYArfgSFGIPQEEFLKALSAFEQLINLIEkgv-------avEQLYQIDETDI 359 Japanese rice
Q5KB39    84 RILHSPEpd---vEANLAYDAIQRALPAME---QCGFQKDIYEEFLDPLLALIRSFAESDETTAne--ySIVQALQDPER 155 Cryptococcus neofor...
A0E9B0    92 YIIESKDq----qILDKFSTIIANSKADLT---AVGYEQIVIDDFYDEIMKQIKLCPNNITIQ------GIVDAFCNKVT 158 Paramecium tetraurelia

4DHJ_I   166 ANYILMFFRLITSAFLKQNSEEYAPFIDEg--------MTVAQYCEQEIEPMWKDADHLAINSLIKAA----GTRVRIEY 233 Caenorhabditis elegans
Q2H586   306 SDSVMYHFRMLASSYLKGHRETYSAFVTGg--------TGVDGYCLEVLERHNVEIDHLGLILLANVLlkdaGFVLEVAY 377 Chaetomium globosum...
Q7SI56   371 SNAIIYHLRLLASSWLKENRGSHEAFITTd--------ESVEKFCQRVIEVPNIEIDQLGLQALVSILlkpvGFVLRVAY 442 Neurospora crassa
KIS69951 165 SNSIVVYLRLLTSAFLKLNADEYTPFLFSldtssdagpPDMASFCANQVEAIGKEADHVQITALSRAL----KVSLDVAY 240
CAM59837 158 AY-VLAALRYLISAYLQEHEEEYEPFVSGlg------yGTVRDYCNAEVELVDHESDNVQLAAFAKAF----NVCIKVYA 226
Q57ZU6   155 AEYALYFYRYAVSHHIRTHEDDFLPFVVGmg------hETVSEFCSVEVDAVASEADNVQVVAFAQCF----DVRVIVEY 224 Trypanosoma brucei
Q4DPS6   152 SEYVIYFYRYAVSNYIRGHKDDFLPFVMGln------yENVEDFCRAEVDAVSSESDNVQVVAFARCF----QLKIVVEY 221 Trypanosoma cruzi
Q7XPN5   360 TKNSLRFLRFLTEIEICTHEDHYKGFLLTad------ySSVFEFCQVEVRPENAEASNEQMKALVEAL----GIPVLVEN 429 Japanese rice
Q5KB39   156 SNYIVVSLRLITSSYIRTHADLFSPFLFSptt---flpLSTEEFCRQEVEPCGKEADNAQIMALAEAM----NAGVRVAY 228 Cryptococcus neofor...
A0E9B0   159 SDYLIMYMRMMTSGYIKANSFLFEGYIET---------GTVELFCQQEVDPIDREADQMQIIALQNYL----QIPIRIFY 225 Paramecium tetraurelia

4DHJ_I   234 MD------------------------------RTa---APNGGWHYDIPsd--------------dQQ------------ 254 Caenorhabditis elegans
Q2H586   378 LD------------------------------RS----PGPEVNTYRIPeean---------grhpSE------------ 402 Chaetomium globosum...
Q7SI56   443 LD------------------------------RS----PGSEVNTYSFPeeai---------sqptSP------------ 467 Neurospora crassa
KIS69951 241 LSpqqappqtpl----------deefpaeqlhQStensSDPTCRASASIpvpgndaq--rtrsaaeHPdrcdvvr----- 303
CAM59837 227 LD------------------------------RN----AGNNITEYSFNged------------ndAE------------ 248
Q57ZU6   225 VD------------------------------GR----EGDCTTRHTFQqkds---------hdanEY------------ 249 Trypanosoma brucei
Q4DPS6   222 LD------------------------------GS----VGTRTTRHSFSgdss----------dtgDN------------ 245 Trypanosoma cruzi
Q7XPN5   430 LDttsetdtpilnqhfiyprpeseegtmlgplNSheivSPESSGYHAARgelqnqpstsgsstnssTEalglqsigtsst 509 Japanese rice
Q5KB39   229 LD------------------------------RSe--vGGKTINWVEFGkd--------------tSE------------ 250 Cryptococcus neofor...
A0E9B0   226 LD----------------------------------------GNVSTFDatifq-------ipedaDS------------ 246 Paramecium tetraurelia

4DHJ_I   255 -------IAPEI------------TLLYRPGHYDVIYK 273 Caenorhabditis elegans
Q2H586   403 -------LGPII------------HLLYRPDHYDILYV 421 Chaetomium globosum CBS 148.51
Q7SI56   468 -------LDPVI------------CLLYRPDHYDILYp 486 Neurospora crassa
KIS69951 304 -feveggQITEIg-----------TMLLRPGHYDLLVE 329
CAM59837 249 -------DRLVV------------GLLYMPGHYNLLGR 267
Q57ZU6   250 -------TTIEV------------TLLYRPGHYDLLYK 268 Trypanosoma brucei
Q4DPS6   246 -------THLVV------------TLLYRPGHYDLLYK 264 Trypanosoma cruzi
Q7XPN5   510 pnerdgkGDRTIndlspaerrrlaILLYRPGHYDILCP 547 Japanese rice
Q5KB39   251 -------NARPL------------TLLYRPGHYDVVTK 269 Cryptococcus neoformans
A0E9B0   247 -------KSIFI------------NLLYRPGHYDILYP 265 Paramecium tetraurelia
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