6LQG


Conserved Protein Domain Family
PEN-2
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pfam10251: PEN-2 
Presenilin enhancer-2 subunit of gamma secretase
This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex.
Links
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Statistics
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PSSM-Id: 463024
Aligned: 41 rows
Threshold Bit Score: 83.4212
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6LQG_D        49 SNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEqSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRP-RW 127
XP_006578788  51 SEEESVGYARRFYTFGFALLPLLWAVNCFYFWPVLRHSHSF---PRIRPYVVGSAIGFAVCATLLSSWSLTFAIGGErLF 127
XP_009122505  45 TEEASVDYARRFYKFGFALLPWLWAVNCFYFWPVLRHSRAF---PQIRNYVVRSAIGFSVFTALLSAWALTFSIGGEeLF 121
XP_006343444  48 SEQESVDHARRFFKFGFLLLPWLWAVNCLYFWPVIRRPSSYYH-PDLRRYVVRSAIGFAVFAVILSSWALTFSIGGErLF 126
XP_002306247  42 TEDESLIYARRFYKFGFALLPWLWAVNCFYFWPVLFNSRSF---PRIRPYVVRSAVGFTVFTTVLCSWALTFAIGGEqLF 118
EEF39540     387 SEEESIKYARRFYKFGYALLPWLWAVNCFYFWPALRNSRSF---PRIRPYVIRSAVGFTAFSILLCSWALTFAIGGErLF 463
XP_006843054  38 DEEDAVKYARNFFRAGFFLLPFLWFLNSFYFWPVLTRSSSF---PRLRPYVLGSAIGFAVFMVLLCLWALTFAIGGErLF 114
Q54BR1        10 DDEKMINIAKKLWFIGFFFLPWVWLINILYFIPYRNSLN-----DKVKWYLKFSLIGFLGYSTIFMGWMGIYLVNRN-KW 83  Dictyostelium d...
EFA82289      10 NDEKMRGIARKLWIAGFFFLPWVWMINILFFLPHRKVLS-----PAIIWYLKYSLIGFFVYTGIFMTWMGIYLVNRN-KW 83 
EGG14582      10 nDDKMRNIAKKLWIIGFFFLPWVWLINILFFFPHRKQLS-----TDVFWYLKYSLIGFFVYSTIFMTWMGIYLVNRN-NW 83 

6LQG_D       128 GALGDYLsFTIPLG 141
XP_006578788 128 GPVWDQL-VMYNLA 140
XP_009122505 122 GPVWDKL-VMYNVA 134
XP_006343444 127 GHVWDKL-VMYNVA 139
XP_002306247 119 GPVWDKL-VMYNVA 131
EEF39540     464 GPVWNEL-VMYNVA 476
XP_006843054 115 GPIWQHL-VMYNVA 127
Q54BR1        84 GAFGDDIsITIPFG 97  Dictyostelium discoideum
EFA82289      84 GAFGDSIsITVPFG 97 
EGG14582      84 GASGDNIsIVIPYG 97
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